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____________________________________________________________ Immunoglobulin Sequence Analysis in Chronic Lymphocytic Leukemia ____________________________________________________________. 26. 9. – 27. 9. 2013 , Hotel International, Husova 16, Brno, Czech Republic.

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5th igcll educational workshop program

____________________________________________________________

Immunoglobulin Sequence Analysis inChronic Lymphocytic Leukemia

____________________________________________________________

26. 9. – 27. 9. 2013, Hotel International, Husova 16, Brno, Czech Republic

Wednesday 25 September 2013Program

____________________________________________________________

19:00Welcome dinner for invited speakers (Hotel International)

Thursday 26 September 2013

____________________________________________________________

8:50SarkaPospisilova(CEITEC MU; University Hospital Brno; CZ)

Welcome

Keynote Lecture

9:00 Nicholas Chiorazzi(The Feinstein Institute for Medical Research, New York, US)

The turbulent life history of CLL

Session I - Modern prognostication in CLL

ChairSarkaPospisilova(CEITEC MU; University Hospital Brno; CZ)

9:45Richard Rosenquist(Uppsala University, Uppsala, SWE)

The genomic landscape of CLL

10:10Kostas Stamatopoulos(G. PapanicolaouHospital, Thessaloniki, GR)

Immunogenetics and prognostication

10:35 PaoloGhia(UniversitaVita-Salute San Raffaele, Milano, IT)

Biological prognostic markers: a critical reappraisal

11:00Coffee break

5th IgCLLEducationalWorkshop Program


5th IgCLLEducationalWorkshop Program

Session II - IG sequence analysis in CLL: technical aspects

ChairRichard Rosenquist(Uppsala University, Uppsala, SWE)

11:30Frederic Davi(HðpitalPitié-Salpêtrière, Paris, FR)

Mechanisms of immunoglobulin diversity

11:50 Anton Langerak(University Medical Center, Rotterdam, NL)

From the patient to the sequence: Primers, PCR, Detection of clonality, Sequencing

12:20 Marie-PauleLefranc(UniversitéMontpellier, Montpellier, FR)

Online tools for Interpretation of IG sequences and navigation through

the IMGT web- resources

12:50 Lunch

Session III - Interpretation of IG sequences

ChairAnastasia Hadzidimitriou(Centre for Research &Technology Hellas, Thessaloniki, GR)

14:00 Veronique Giudicelli(Université Montpellier, Montpellier, FR)

How to use the IMGT/V-QUEST tool

14:30 Basic exercises I

15:15 Solutions

Karla Plevova(CEITEC MasarykUniversity; University Hospital Brno; CZ)

15:45 Coffee break

16:15 Basic exercises II

17:00 Solutions

VasilisBikos(CEITEC Masaryk University, CZ)

18:00 Visit to Mendel Museum, social event


5th IgCLLEducationalWorkshop Program

Friday 27 September 2013

____________________________________________________________

Session IV - Interpretation of IG sequences: advanced exercises

ChairChrysoulaBelessi(General HospitalofNikea, Athens, GR)

8:30Advanced exercisesI

9:15 Solutions

Lesley Ann Sutton (Uppsala University, Uppsala, SWE)

9:45 Advanced exercisesII

10:30 Solutions

Andreas Agathangelidis(Università Vita-Salute San Raffaele, Milano, IT)

11:00Coffee break

Session V - IG sequence analysis for everyone

ChairPaolo Ghia(Universita Vita-Salute San Raffaele, Milano, IT)

11:30 Richard Rosenquist(Uppsala University, Uppsala, SWE)

How to report IG sequence data in clinical routine

11:50KathleenPotter (University of Southampton, Southampton, UK)

Methodological harmonization, guidance

Session VI - Where do we go now?

ChairKostas Stamatopoulos(G. Papanicolaou Hospital, Thessaloniki, GR)

12:10 Fiona Murray (Uppsala University, Uppsala, SWE)

Recombinant antibodies in autoimmunity and malignancy: a key to improved understanding of immune processes

12:30 Anton Langerak(University Medical Center, Rotterdam, NL)

Immunogenetics in the NGS era: challenges and limitations

12:50 SarkaPospisilova(CEITEC MU; University Hospital Brno; CZ)

Concluding remarks

13:00Lunch


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