Pyrexia of Unknown Origin. Stephen Hughes MRCPCH PhD Consultant Paediatric Immunologist. PRE-TEST. The commonest cause of PUO is: A common disease presenting in an atypical way. A rare disease presenting in atypical way. A common disease presenting typically.
} 80% of malignancies with PUO
Q. is she immune suppressed?
Q. What is the diagnosis?
Q. Evidence for recent immune dysregulation (Igs, B and T cells)
Necrotising histiocytic lymphadenitis
Normal histiocytes and lymphocytes