Parkinson’s Disease and Skeletal Health. Minneapolis VA Medicine Research Conference January 22, 2009 Howard Fink, MD, MPH. Summary. There is accumulating evidence that PD is an important osteoporosis risk factor. Summary.
Parkinson’s Disease and Skeletal Health
Minneapolis VA Medicine Research Conference
January 22, 2009
Howard Fink, MD, MPH
1Taylor BC, JAGS 2004
Association Between Parkinson’s Disease and Low Bone Density and Falls in Older Men:
The Osteoporotic Fractures in Men (MrOS) Study.
Fink HA, Kuskowski MA, Orwoll ES, Cauley JA, Ensrud KE.
J Am Geriatr Soc 53:1559–1564, 2005
The association of Parkinson’s disease with bone mineral density and fracture in older women Schneider JL, Fink HA, Ewing SK, Ensrud KE, Cummings SR, for the Study of Osteoporotic Fractures (SOF) Research GroupOsteoporos Int 2008;19:1093-97
Measured at visit 4
Measured at visit 2
Association of Parkinson’s disease with accelerated bone loss, fractures and mortality in older men: the Osteoporotic Fractures in Men (MrOS) study Fink HA, Kuskowski MA, Taylor BC, Schousboe JT, Orwoll ES, Ensrud KE, for the Osteoporotic Fractures in Men (MrOS) Study GroupOsteoporos Int 2008;19:1277-82
+ Prospective studies allow collection of extensive pre-fx measures
Why might PD be associated with osteoporosis?
1 Fink HA, Osteoporos Int 2008;19:1277-82
1Vestergaard P, Calcif Tissue Int 2007;81:153-61.
What, if anything, should be done about this?
Amelioration of osteoporosis by menatetrenone in elderly female Parkinson’s Disease patients with vitamin D deficiency.Sato Y, et al. Bone 2002;31:114.
Amelioration of osteopenia and hypovitaminosis D by 1-alpha-hydroxyvitamin D3 in elderly patients with Parkinson’s disease. Sato Y, et al. J Neurol Neurosurg Psychiatry 1999;66:64.
Alendronate and vitamin D2 for prevention of hip fracture in Parkinson’s Disease: a randomized controlled trial. Sato Y, et al. Movement Disorders 2006;21:924.
1Eng ML, Mov Disord 2006;21:2265-66