COMPLICATIONS OF ATHEROSCLEROSIS:  THE CLINICAL SYNDROMES

COMPLICATIONS OF ATHEROSCLEROSIS: THE CLINICAL SYNDROMES PowerPoint PPT Presentation


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Supply and Demand. VESSELEnd artery, collateral, dual.PERFUSIONHR x SV = CO PVR = BPHEMOGLOBINOXYGENNATURE OF OCCLUSION. HYPERTROPHY?WORK?BMR. Decreased Perfusion Past a Stenosis. Reduced flow, or decreased oxygen (anemia)Heart: pain = anginaGut: pain = angina and diarrheaLegs: p

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COMPLICATIONS OF ATHEROSCLEROSIS: THE CLINICAL SYNDROMES

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1. COMPLICATIONS OF ATHEROSCLEROSIS: THE CLINICAL SYNDROMES

2. Supply and Demand VESSEL End artery, collateral, dual. PERFUSION HR x SV = CO + PVR = BP HEMOGLOBIN OXYGEN NATURE OF OCCLUSION HYPERTROPHY ?WORK ?BMR

3. Decreased Perfusion Past a Stenosis Reduced flow, or decreased oxygen (anemia) Heart: pain = angina Gut: pain = angina and diarrhea Legs: pain and weakness (claudication) CNS: faintness, syncope, TIA

4. Decreased Perfusion Past a Stenosis: SUSTAINED! Ischemic necrosis in cells FARTHEST FROM ORIGIN OF CIRCULATION Heart: subendocardial infarct Brain: watershed infarct Gut: watershed infarct

5. Complete Thrombotic Occlusion Heart: Transmural myocardial infarct in territory of artery CNS: Dependent on efficacy of circle of Willis Dual circulations: Lung and Liver: dependent on efficacy of other circulation. Infarcts hemorrhagic

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