Supply and Demand. VESSELEnd artery, collateral, dual.PERFUSIONHR x SV = CO PVR = BPHEMOGLOBINOXYGENNATURE OF OCCLUSION. HYPERTROPHY?WORK?BMR. Decreased Perfusion Past a Stenosis. Reduced flow, or decreased oxygen (anemia)Heart: pain = anginaGut: pain = angina and diarrheaLegs: p
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1. COMPLICATIONS OF ATHEROSCLEROSIS: THE CLINICAL SYNDROMES
2. Supply and Demand VESSEL
End artery, collateral, dual.
HR x SV = CO
+ PVR = BP
NATURE OF OCCLUSION
3. Decreased Perfusion Past a Stenosis Reduced flow, or decreased oxygen (anemia)
Heart: pain = angina
Gut: pain = angina and diarrhea
Legs: pain and weakness (claudication)
CNS: faintness, syncope, TIA
4. Decreased Perfusion Past a Stenosis: SUSTAINED! Ischemic necrosis in cells FARTHEST FROM ORIGIN OF CIRCULATION
Heart: subendocardial infarct
Brain: watershed infarct
Gut: watershed infarct
5. Complete Thrombotic Occlusion Heart: Transmural myocardial infarct in territory of artery
CNS: Dependent on efficacy of circle of Willis
Dual circulations: Lung and Liver: dependent on efficacy of other circulation.