1 / 36

10 mV

100 ms. 10 mV. 5 s. 10 mV. 5 s. Transient current injection to the cell can toggle its state. I. V. I. V. Climbing Fiber. Parallel Fiber. Climbing fibers response and Ca changes. LTD: Long Term Depression. LTD time course. LTD: specificity. PSTH: Post Stimulus Time Histogram.

kieve
Download Presentation

10 mV

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 100 ms 10 mV 5 s

  2. 10 mV 5 s

  3. Transient current injection to the cell can toggle its state

  4. I V I V

  5. Climbing Fiber Parallel Fiber

  6. Climbing fibers response and Ca changes

  7. LTD: Long Term Depression

  8. LTD time course

  9. LTD: specificity PSTH: Post Stimulus Time Histogram

  10. LTD: Properties

  11. Involvement of AMPA receptors in LTD induction. Pairing PF-mediated EPSPs with depolarization of PCs Pairing quisqualate application with depolarization of cultured PCs

  12. BAPTA PKC (19¯36) Control PKC(glu27) (19¯36) Involvement of mGluR1 and PKC in LTD induction. control In the presence of antibodies inactivating mGluR1 The same in knockout mice lacking functional mGluR1

  13. Mechanism of LTD

  14. SS activity following vestibular stimulation CS activity following optical stimulation

  15. Mechanism of VOR gain change

  16. L7-PKC transgene

  17. Expression of PKC in L7-PKC mice

  18. LTD in L7-PKC mice Glutamate+Depolarization

  19. VOR gain change in L7-PKC mice

  20. Involvement of PKC activation in LTD induction. BAPTA PKC (19¯36) Control PKC(glu27) (19¯36) Control NOS inhibitor L-NMMA

More Related