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Deliberations of the 19 th Meeting of the Expert Review Committee on Polio Eradication in Nigeria (ERC) 22-24 March 2009. Context. 3 rd Quarter 2008. 4 th Quarter 2009. New Tactics in Nigeria: impact of engaging sub-national & local leaders in 2009. Feb: Nigeria's state Governors sign

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Deliberations of the 19th Meeting of the Expert Review Committee on Polio Eradication in Nigeria (ERC)22-24 March 2009



3rd Quarter 2008

4th Quarter 2009

New Tactics in Nigeria: impact of engaging sub-national & local leaders in 2009

Feb: Nigeria's state Governors sign

'Abuja Commitments on Polio'

June: Sultan of Sokoto & traditional leaders constitute Polio Committee


Uttar Pradesh

Nov 09

Dec 09

Jan 10

Feb 10

Bihar

Feb 10

Jan 10

Nov 09

Dec 09

New Tactics in India: very high population immunity is leading to similar progress!

Type 1 immunity in late

2007 vs 2009, West UP


Now we have a golden opportunity globally polio reporting districts last 6 months

Africa Synchronized Polio Campaign

19 countries; 85 million children

6 Mar & 24 Apr 2010

type 1

type 3

types 1 & 3

Now we have a 'Golden Opportunity' globallyPolio-reporting districts, last 6 months


Today i declare the war against polio in chad
'Today, I declare the war against polio in Chad'

H.E. the President of Chad M. Idress Deby6 March 2010



Questions
Questions

What population immunity threshold stops WPV in Nigeria? Is North/South, urban/rural same?

What add'l strategies/activities could achieve the population immunity threshold to interrupt WPV?

What is the optimal SIA schedule & vaccine(s) for the rest of 2010 to interrupt WPV & cVDPV?


Questions cont d
Questions cont’d

How can recent IPD quality gains be rapidly applied to routine EPI? How do we balance?

Pros & Cons of an extensive ‘mop up’ approach?

Could SIA number be reduced in return for better quality in 2nd half of 2010?


Questions cont d cont d
Questions cont’d & cont'd….

LQAS: how frequent & how wide?

What levels of failure in LQAS prompt a ‘re-do’?

What are the key research questions for Nigeria?

What is ERC’s self-evaluation at this stage?



ERC Findings (1)

Polio & EPI progress since 2009

The ERC is deeply impressed by the progress towards polio eradication & EPI strengthening due to an unprecedented drive co-ordinated by Federal Authorities, led by State Governors & Traditional Leaders, implemented by LGAs and supported by partners!


Most recent polio-paralyzed child was in Kano was on 17 Feb due to the cVDPV2!

Polio cases: 2

Infected states: 2

Impact:comparison of polio cases in 2009 & 2010 at 12 March each year, Nigeria

2010

2009

Polio cases: 86

Infected states: 20

Polio cases: 1

Infected states: 1


ERC Findings (2) due to the cVDPV2!

Population Immunity Thresholds

Models using data from Nigerian states show population immunity must be >80% to stop polio.

There is no difference in this 'immunity threshold' between north & south Nigeria.

The immunity threshold appears to be higher in urban areas (e.g. > 85%).


Estimated population immunity thresholds to stop wild poliovirus transmission nigeria 1997 2009
Estimated Population Immunity Thresholds to Stop Wild Poliovirus Transmission, Nigeria 1997-2009*

Serotype 3

>80% population

immunity

>80% population

immunity

Serotype 1

* district-year observations (# above each bar); data at Aug; district-years where 10+ NPAFP; mOPV3 efficacy = mOPV1


ERC Findings (3) Poliovirus Transmission, Nigeria 1997-2009*

Population Immunity Thresholds

ERC is alarmed that vaccine-induced immunity is not above threshold:

  • in at least 2 'extremely' high risk states (Kano, Zamfara).

  • in 85 high risk LGAs in 12 states & FCT.

    ERC cautions that in these areas, the extremely low virus numbers are only due to a combination of natural immunity & vaccine-immunity.


Vaccine induced immunity in children 0 4 years 2005 jun 2009 serotype 1
Vaccine-induced immunity in children 0-4 years Poliovirus Transmission, Nigeria 1997-2009*2005- Jun 2009: serotype 1

Persistent VERY High Risk Zone for ongoing polio transmission

Type 1 case

% of children protected by direct OPV immunisation against type 1

*


2009 Poliovirus Transmission, Nigeria 1997-2009*

>= 20%

10 - 19%

0 - 9%

Persistent sub-optimal population immunity

Proportion of Non Polio Cases never vaccinated with OPV

State & LGA-level AFP

AFP & monitoring data

tell you the same thing,

but much faster,

than fancy models!!

Source: National AFP Surveillance Database


ERC Findings (4) Poliovirus Transmission, Nigeria 1997-2009*

Risk of Ongoing Polio & New Importations

Nigeria remains at very high risk of polio due to:

  • undetected poliovirus due to ongoing surveillance gaps as evidenced by orphan viruses & poor AFP-performing LGAs (& anecdotal reports of possible specimen tampering!).

  • risk of new importations from Chad (as in 2009) and/or Senegal (largest type 1 outbreak so far in 2010!).


Variables associated with Poliovirus Transmission, Nigeria 1997-2009*outbreaks: Africa 2003-9*

  • poor population immunity

  • bordering Nigeria.

  • movement of people to/from Nigeria.

  • high proportion of population aged 0-14.

THE RISKS OF WILD POLIOVIRUS SPREAD IN AFRICA COULD NOW BE REVERSED!

*Imperial College Analysis, Feb 2010

Pattern of wild poliovirus spread, 2003-2009

Importations of Nigeria origin

Importations of India origin

Endemic countries

Countries with outbreak due to imported wild poliovirus


ERC Findings (5) Poliovirus Transmission, Nigeria 1997-2009*

Immunization Systems Strengthening

Though routine coverage is still low, ERC recognizes & congratulates the major progress in:

  • Political attention & resources to routine immunization,

  • Scrutinizing & beginning to reconcile major data problems,

  • A multi-pronged approach to both raise coverage & strengthen the underlying system, and

  • State efforts to achieve rapid gains in reducing the 'unimmunized' (but premature to promote best practices!)


Major ERC Recommendations Poliovirus Transmission, Nigeria 1997-2009*


Polio Eradication Poliovirus Transmission, Nigeria 1997-2009*


ERC Recommendations (1.1) Poliovirus Transmission, Nigeria 1997-2009*

Engagement of Political Leaders

The ERC strongly supports the tracking & public reporting on the Abuja Commitments and recommends this be implemented quarterly.

Given the critical important of Very High Risk LGAs, key indicators should also be reported publicly for these LGAs & Chairmen on a quarterly basis (e.g. functional LGA Task Force, daily LGA mtgs with Chairman).


ERC Recommendations (1.1) Poliovirus Transmission, Nigeria 1997-2009*

Role of Traditional Leaders

ERC recognizes & strongly commends the essential role of Traditional Leaders in improving IPD quality through social mobilization, team supervision & addressing non-compliance.

ERC requests Traditional Leaders to ensure 100% of Ward & Village Heads play a supervisory role in upcoming IPDs in HR/VHR LGAs & track this closely.


Answer 2: Poliovirus Transmission, Nigeria 1997-2009*stopping types 1, 2 & 3 poliovirus by end-2010 requires the right mix of (a) campaign schedule, (b) vaccine & (c) SIA quality improvements.

(this goal appears feasible!)


ERC Recommendations (2.1) Poliovirus Transmission, Nigeria 1997-2009*

IPD/SIA Schedule & Vaccine of Choice

tOPV in Child Health Week (CHW)

bOPV

(high risk)

bOPV/mOPV

(high risk)

tOPV?/bOPV

(Kano & very high risk areas)

Jul

Aug

Sept

Oct

Nov

Dec

Apr

May

Jun


ERC Recommendations (2.2) Poliovirus Transmission, Nigeria 1997-2009*

IPD/SIA Schedule & Vaccine of Choice

Any WPV or cVDPV must now trigger mop-ups!

Mop-ups are additive to the larger SIA schedule & cannot replace IPDs.

Replacing IPDs with mop-ups would be highly risky, as seen in Pakistan & India in the early 2000s where a shift to mop-ups contributed to large outbreaks.


ERC Recommendations (2.3) Poliovirus Transmission, Nigeria 1997-2009*

IPD Schedule & Choice of Vaccine (cont'd)

IPDs in 1st half of 2011

  • 2 sub National IPDs in highest risk areas.

  • 2 nationwide IPDs (consideration should be given to aligning activities with measles campaigns & CHWs).


ERC Recommendations (3.1) Poliovirus Transmission, Nigeria 1997-2009*

Improving IPD Quality = Very High Risk LGAs

VHR & HR LGAs are different! LGA-specific plans, LGA Chairmen oversight & Task Forces are essential for April IPD!

For these areas Traditional Leaders should aim for supervisory role by 100% of Ward & Village Heads.

These areas should be targeted for the high impact social mobilization activities (e.g. Majigi films, IPC).


Reasons for missed children Poliovirus Transmission, Nigeria 1997-2009*March 2010 IPDs

34 VHR LGAs

Other LGAs

ERC Recommendations (3.2)

Improving IPD Quality = Very High Risk LGAs!

Proportion of wards with > 10% missed children

HR LGAs (51 LGAS)

VHR LGAs (34 LGAs)


ERC Recommendations (3.3) Poliovirus Transmission, Nigeria 1997-2009*

Improving IPD Quality – Social Mobilization

The ERC is impressed with the range & of the scope of social mobilization activities and recommends:

  • mass awareness raising activities (eg. media, celebrities), must now be complemented with specific, tailored approaches for the VHR & HR areas, and

  • clear parameters/indicators should be established for 'scaling-up' specific communications interventions, esp. in HR/VHR wards, and reported out at the next ERC.


ERC Recommendations (4.1) Poliovirus Transmission, Nigeria 1997-2009*

Monitoring the Quality of IPDs & Mop-ups

Independent monitoring should be the standard for monitoring IPD quality.

At this critical point, any area in a with <90% in a High Risk State should be recovered & reported immediately & tracked at both state & Federal levels.

LQAS should be reserved for any LGA that poses a particular risk to national health security (see criteria).


Comparison of independent monitoring lqas results nov 2009 ipd nigeria

Sufficient missed children to Poliovirus Transmission, Nigeria 1997-2009*

sustain polio transmission

Comparison of Independent Monitoring & LQAS Results, Nov 2009 IPD, Nigeria)

IM

(Inside)

IM

(Outside)

LQAS


ERC Recommendations (4.2) Poliovirus Transmission, Nigeria 1997-2009*

Monitoring the Quality of IPDs & Mop-ups

Primary criteria for use of LQAS:

  • HR/VHR LGAs with inconsistent IPD performance data (e.g. NPAFP cases vs. IM data; strong anecdotal reports; coverage vs. epidemiologic data).

  • urban & peri-urban HR/VHR LGAs (due to higher risk of persistent transmission).

  • re-infected areas (WPV or cVDPV).


ERC Recommendations (5) Poliovirus Transmission, Nigeria 1997-2009*

Surveillance & Lab Priorities

Further analyze existing data (within 1 month): for HR/VHR areas (a) scrutinize Sabin & NPEV trends, (b) analyze trend in Sabin excretion rates, (c) analyze history of orphan viruses.

Generate new data: environmental surveillance (Kano, Maidiguri), seroprevalence survey (e.g. high priority for Kano).

Establish mechanism to validate authenticity of stool samples.

The 1st priority for surveillance strengthening should be any HR or VHR LGA areas with orphan viruses.


Immunization Systems Poliovirus Transmission, Nigeria 1997-2009*


ERC Recommendations (1.1) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System – Overall Strategy

ERC stresses importance of dual approach that raises coverage and strengthens the immunization system:

  • Raising coverage: ERC endorses the Child Health Weeks, 2 times per year.

  • Systems strengthening: fully implement Reaching Every Ward (REW) strategy; infrastructure plan (cold chain, transport); vaccine forecasting; HR mapping & sessions monitoring.

  • Targets: align national targets with National Strategic Health Development Plan (NSHDP).


Child health weeks the package
Child Health Weeks: the package Poliovirus Transmission, Nigeria 1997-2009*

Nutrition

Vit A, De-worming,

MUAC screening

Immunization

OPV, DPT/HepB, MV

LLIN Distribution

Care for Pregnant Women

TT, SP for IPT, Fe/Folate

Health Education

KHHP, Hand washing

nphcda


ERC Recommendations (1.2) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System – Overall Strategy

ERC further recommends:

  • State Task Forces: state & LGA polio Task Forces should be expanded by end-2010 to include full immunization agenda.

  • Financing: every State & LGA should have a budget line item for routine immunization; this should be tracked at State & Federal levels.

  • Traditional Leaders: should be invited by State/LGA authorities to systematically promote & support the broader immunization agenda, building on their very successful role in polio eradication.


ERC Recommendations (2) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System - Data


ERC Recommendations (2) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System - Data

The ERC is impressed with the particular attention being given to reconciling the major (& ongoing!) data quality problems.

  • Data Quality Self-Assessment (DQS): the limitations of this tool must be clearly understood so that it can be applied appropriately.

  • Data Quality Checks (DQC): supplement vaccine data with systems capacity & performance data (e.g. human resources, facilities, completeness of planned & outreach sessions).

    DHS and similar data are the gold standard for assessing immunization performance, and should guide further improvements to data collection & accuracy!


ERC Recommendations (3) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System – Service Delivery

REW Strategy: states should complete & prioritized plans for implementation based on (a) HR and VHR LGAs, and (b) the number of unimmunized children.

The '1,2, 3 Strategy': ERC endorses the strategy of implementing and monitoring

  • 1 routine session/week in all Health Centers,

  • 2 outreach sessions/week from all Health Centers, and

  • 3 LGA-level supervisory visits/month of each HC's activities.


ERC Recommendations (4) Poliovirus Transmission, Nigeria 1997-2009*

Immunization System – Infrastructure

  • Vaccine management

  • Cold chain

  • Facilities

  • Human resources

  • Transport

Issue-specific recommendations in the main ERC Report


Accelerated Disease Control Poliovirus Transmission, Nigeria 1997-2009*

&

Other Issues


ERC Recommendations (1) Poliovirus Transmission, Nigeria 1997-2009*

Accelerated Disease Control

The full agenda of ADC activities must be included in NPHCDA's multi-year plan to optimize coordination across the broad range of SIAs now being promoted in Nigeria.

ERC welcomes the Special Measles Consultation & requests to be informed of the outcomes to guide ERC's work; if possible, such meetings should be held before the ERC in future.


ERC Recommendations (2) Poliovirus Transmission, Nigeria 1997-2009*

Research Priorities

ERC notes & endorses NPHCDA's Special Consultation on Polio Research Priorities, requesting:

  • the deliberations, findings and recommendations be shared with the ERC within 10 days, and

  • rapid attention be given to implementing the major recommendations & reporting on these to the ERC.


ERC Recommendations (3) Poliovirus Transmission, Nigeria 1997-2009*

Self-Evaluation

NPHCDA should review the ERC with particular attention to:

  • reducing overlapping &/or over-represented expertise.

  • addressing potential gaps in critical expertise (e.g. health systems, communications).

  • reconciling real or perceived conflicts of interest (e.g. due to potential for self-evaluation).

  • ensuring full delineation & application of rules of procedure, membership, terms, etc.


There is much too celebrate….but remember! Poliovirus Transmission, Nigeria 1997-2009*

Within the past 4 months, Nigerian children have still been paralyzed by a type 1, 2 & 3 poliovirus!


Everyone must do the extra-ordinary to 'END POLIO NOW'! Poliovirus Transmission, Nigeria 1997-2009*




What's Different in 2010-12? get OPV!

Virus persists in smaller

areas & sub-groups

than previously thought.

  • district-specific plans & capacity.

  • special tactics for underserved groups.

Optimizing mOPV use &

validating coverage is more

difficult than anticipated.

  • bivalent types 1& 3 OPV (bOPV)

  • independent campaign monitoring

Routes of poliovirus

spread & outbreaks are

now largely predictable.

  • immunization systems strengthening.

  • new outbreak response standards.

  • pre-planned, synchronized campaigns.

New Strategic Plan, 2010-12

Major Lessons


Vaccine-induced immunity in children 0-4 years get OPV!2005- Jun 2009: serotype 3

Type 3 case

% of children protected by direct OPV immunisation against type 3

*


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