European Strategy Forum on Research Infrastructures

2. European Strategy Forum on Research Infrastructures

3. ESFRI roadmap BBMRI – biobanking EATRIS – translational research ECRIN – clinical trials ELIXIR – bioinformatics Infrafrontier– animal disease models INSTRUCT – structural biology EU-OPENSCREEN – chemical biology BLS4 – high security labs Euro-BioImaging - bioimaging EMBRC – marine biology Update in Update in Update in Dec Dec Dec 2008 2008 2008 35 projects First First First roadmap roadmap roadmap in 2006 in 2006 in 2006 + 10 projects

4. Grand Challenges - Understand genetic and environmental impact on human health - Develop novel strategies for diagnosis, prevention and therapies

5. Why mouse? • Mouse genome fully sequenced • 95% similarity of the genes of mice and men • Easy to breed and handle in captivity • Extensive toolbox for manipulating the mouse genome Current Biology

6. Why mouse? Publications on ‘Mouse Models’ Mouse models achieve high impact

7. The challenge • Shortage on capacities and access: • Phenotyping (characterising mouse models) • Mouse Clinics EUMODIC,Infrafrontier • Archiving and Dissemination of mice and data • Repositories EMMA,Infrafrontier

8. Required capacities • Phenotyping • Archiving and distribution 1500 p.a. 1500 p.a. 420 p.a. 350 p.a.

9. Infrafrontier: two main parts Infrafrontier Archivefrontier Phenomefrontier Archivefrontier/EMMA Systemic Phenotyping Archiving / Distribution + emerging centres + emerging centres Access to phenotyping data and mouse models Access to phenotyping services, data and mouse models

10. Capacity building required!

11. Osteogenesis imperfecta • A group of genetic bone disorders ... • Noted People with OI • Jazz pianist Michel Petrucciani • Actor writer and ethicist Peter Radke... • In the mouse model: • Bisphosphonate treatment • … reverses bone phenotype • … but does not lower mortality

12. The German Mouse Clinic Nature Methods 2005, Nature Genetics 2005, Nature Genetics 2008, Cell 2009 www.mouseclinic.de

13. Mouse model for Osteogenesis imperfecta • - Mutation in collagen I • Bone phenotype • Mineralisation defect • Bone deformity • fractures • Beaded ribs • Reduced Bone mineral content & decreased bone mineral density • Systemic • Lung phenotype • Heart phenotype • Reduced fat mass & increased lean mass • Metabolic alterations

14. Infrafrontier partners 12 European Countries + Canada Research Institutions + Funding Agencies

15. Infrafrontier partners

16. Smaller Project Large Project Infrastructure

17. Very large Project:International Mouse Phenotyping Consortium (IMPC)

18. Infrafrontier and IMPC • Keep in mind: • Infrafrontier is a BMS research infrastructure, NOT a single project • Infrafrontier has a different and broader portfolio than IMPC (infrastructure for bottom-up and top-down projects) • State of the art research infrastructures are highly dynamic entities

19. Infrafrontier preparatory phase • Official start: 01 March 2008 • 36 months until: 28 February 2011 • 4.5 Mio € funding by the European Commission www.infrafrontier.eu

20. Infrafrontier implementation

21. Infrafrontier implementation

22. Access to mouse resources and data

23. Operation Costs ES Cell Distribution ? € per line User Fees 500 –700 € Mouse Archiving 3,500 – 4,400 € per line Mouse Distribution 1,100 – 2,100 € per line User Fees 1,100 – 1,700 € Cohort Breeding 23,000 – 30,000 € per line Phenotyping 15,000 – 20,000 € per line User Fees to be developed

24. New mouse clinics and EMMA nodes Established facilities New facilities

25. Funding Strategy National and European Projects National infrastructure funds Integration of national & European funds Technology Development Operation Personnel Physical Infrastructure

26. Decentralised funding model MS MS MS MS MS MS European Commission Central Coordination MS = Member State

27. Governance Infrafrontier ERIC (Boards)

28. Governance Infrafrontier ERIC (Tasks)

29. More Information …. www.infrafrontier.eu

30. Resource Sharing Policy • The Rome Agenda: • “Funding organizations should … cover the costs of deposition of materials arising from projects as part of the project budget.” • “Funding agencies should … ensure appropriate data-sharing plans at the outset of projects …”

31. More Information …. • Coordinator: • Prof. Dr. Martin Hrabé de Angelis • hrabe@helmholtz-muenchen.de • Project Office: • Dr. Michael Raess • Dr. Ana de Castro • infrafrontier@helmholtz-muenchen.de • Helmholtz Zentrum München • Institute of Experimental Genetics • Ingolstädter Landstrasse 1 • 85764 Neuherberg

33. Scope of Activities

34. Constructing Required Capacities EMMA Repository Initial Investment (100 mouse lines): ~ 6,600,000 € for Construction ~ 2,000,000 € for Equipment Adding capacities for 100 lines ~ 1,300,000 € Mouse Clinics Initial Investment (100 mouse lines): ~ 15,000,000 € for Construction ~ 5,000,000 € for Equipment Adding capacities for 100 lines ~ 6,500,000 €

35. Maintaining Capacities EMMA Repository Cryo-Archive (100 mouse lines): ~ 10,000 € per year Maintaining and Updating Equipment ~ 10% of Purchasing Price per year Mouse Clinics Maintaining and Updating Equipment ~ 20% of Purchasing Price per year

36. Infrafrontier project – key objectives • Preparation to meet increasing demands for phenotyping and archiving – capacity building • Developing a business plan based on a sustainable funding concept • Identification of the most suitable legal form • Providing a strategic plan for the construction phase • Reaching a legal agreement between all partners

37. Key deliverables • WP2 – Strategy and Governance • WP3 – Legal Work • WP4 – Financial Work & Funding Implementation Preparatory Phase 2008 2009 2010 2011 Strategic Plan Draft Strategic Plan Update WP2   WP4Finance  Business Plan WP3Legal Work  Legal status MoU