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Liquid Chromatography

Liquid Chromatography. Ulrich Tallarek and Ernst Bayer Institute of Organic Chemistry University of Tübingen Tübingen, Germany Dagmar van Dusschoten and Henk Van As WnmrC. Fluid Flow. moving fluid. “stationary fluid”. overall flow direction of fluid. internal pore. 0.15. 0.10. 0.05.

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Liquid Chromatography

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  1. Liquid Chromatography Ulrich Tallarek and Ernst Bayer Institute of Organic Chemistry University of Tübingen Tübingen, Germany Dagmar van Dusschoten and Henk Van As WnmrC

  2. Fluid Flow moving fluid “stationary fluid” overall flow direction of fluid internal pore

  3. 0.15 0.10 0.05 0.00 0.0000 0.0005 0.0010 0.0015 Mass Transfer “stationary” fluid (21%) diffusion within particles Conditions - water flow rate: 8.8 mL/min - observation time: 30 ms moving fluid (79%) dispersion between particles Averaged Propagator [a.u.] Dynamic Displacements [m]

  4. Axial dispersion Pixel number NMR Image of Column

  5. Transport Parameters • Intra-particle diffusion and tortuosity • Inter-particle dispersion and porosity • Stagnant mobile phase mass transfer • Spatial distribution in packed beds

  6. Relevance • (Bio)chromatography, ion exchange, and adsorption • Separation science, and technology • Groundwater flow and contaminant dispersion • Chemical engineering and bioreactor mass transfer • Column operation and compression technology

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