The Institutional Development Award (IDeA) Program. W. Fred Taylor, PH.D. National Institute of General Medical Science National Institutes of Health May 25, 2012. Program Overview Centers of Biomedical Excellence (COBRE) Phase I, Phase II, Phase III
W. Fred Taylor, PH.D.
National Institute of General Medical Science
National Institutes of Health
May 25, 2012
Enhancement of research facilities
Research education and training
INBRE: 24 statewide networks
COBRE: 84 thematic research centers
administrativeModel of COBRE
Develop advanced research infrastructure and a critical mass of investigators in thematic areas
Research Projects (Junior and Senior Investigators)
Research Cores that are essential for basic and clinical research
Pilot Project Program
Research Projects (Junior Investigators)
Phase III: Transitional Centers
Summary of COBRE Scientific Themes
Funding Opportunity Announcement: IDeA-CTR (PAR-11-229)
Key Component Activities (Required)
Biomedical Informatics Resources
Partnerships and Collaborations within and across IDeA-eligible states
Recruitment of Clinical/ Translational Faculty
Clinical and Translational Pilot Grants Program
Clinical Research Design, Epidemiology, and Biostatistics Core
Ethics, Regulatory Knowledge and Other
Community Engagement and Outreach
Clinical Research Education, Mentoring, and Career Development Core
Technologies and Resources for Core Laboratories
Clinical Research Resources and Facilities
Potential Key Component Activities
Institutions or Institutes
PUI = Primarily Undergraduate Institution
Wichita State Univ.
Kansas State Univ.
Kansas Univ. Lawrence
Building new strengths in Cell and Developmental Biology in the state of KS thereby paving new strategies to improve human healthKANSAS-INBRE Organization
Summary of INBRE Scientific Themes
In fiscal year 2011:
http://canhr.uaf.edu/ based research programs to address health disparities in rural and urban special populations
Yup’ik Perceptions of Body Weight and Diabetes:
Cultural Pathways to Prevention
Yup’ik Experiences of Stress and Coping:
Intervention Via Cultural Understanding
Contaminants and Nutrients in Alaskan Subsistence Foods: Striking a Balance
Developing a Novel Set of Diet Pattern Biomarkers Based on Stable Isotope Ratios
Analyzing river water and fish on the Crow Reservation to identify environmental contaminants
- enteric pathogensEnvironmental Health Science in Montana
IDeA Co-funding identify environmental contaminants
IDeA Net Institutes and Centers in fiscal year 2012.
Provides: Institutes and Centers in fiscal year 2012.
http://www.loni.org/ Institutes and Centers in fiscal year 2012.
Northeast Cyberinfrastructure Consortium (NECC) Institutes and Centers in fiscal year 2012.
Multiple partnerships are formed between state university systems and private telecommunications companies to build regional high-speed networks in VT, NH, ME, RI and DE.
Cyberinfrastructure-Enabled Research and Training Institutes and Centers in fiscal year 2012.
Skate genome sequence assembly and annotation project
MDIBL participated Howard Hughes medical Institute’s Science Education Alliance
Maine INBRE Newsletter
The Bar Harbor Times
Provides leadership and communication for the development, promotion and improvement of the IDeA Program
Selected Science Advances COBRE grants
COBRE PI: Tom Curry, University of Kentucky College of Medicine
Background: HIV-associated dementia (HAD) occurs in about 30% of all HIV-infected individuals despite aggressive anti-retroviral therapy. In vitro studies indicate that the hormone estrogen (17β-estradiol or E2) acts as a neuroprotective agent by suppressing the production of HIV-encoded proteins by astrocytes. The role of estrogen receptors in this process is unclear.
Advance: In vitro studies revealed that astrocytes have low levels of ERα expression. Surprisingly, the presence of ERα appeared to negate the reduction in HIV protein production that results from treatment with estrogen. Analysis of postmortem brain samples showed increased density of ERα-positive astrocytes in HIV-infected individuals with dementia compared to those without cognitive deficits. The data suggest that E2 may have the most dramatic effect in reducing HIV transcription and acting as a neuroprotective agent early in the disease process when the subpopulation of astrocytes expressing ERα is low.
How NCRR Grant Enabled Advance: NCRR COBRE grant (P20 RR18727), provided support to the research project and core facilities.
Public Health Impact: Neurological complications are observed in about 60% of all HIV infected patients, dementia in about 30% despite anti-retroviral therapy. It is imperative that effective neuroprotective agents be developed if neurological complications of HIV are to be prevented.
Publication Citation and Link: http://www.ncbi.nlm.nih.gov/pubmed/19886840
PI: Scott Whittemore Univ of Louisville School of Medicine
Background: Multiple molecular, biochemical, and cellular events ensue following traumatic spinal cord injury (SCI). The prevention and/or attenuation of significant morbidity following SCI will require various neuroprotective strategies.
Advance: Following experimental SCI, studies in rats indicate that transplantation of adult oligodendrocyte precursor cells (OPCs) that express ciliary neurotrophic factor (CNTF) resulted in histological, physiological, and functional evidence of recovery. Another study demonstrate that administration of rolipram, an investigational anti-inflammatory agent, spared the death of oligodendrocytes, improved neurotransmission, and reduced hind limb errors during grid walking. In yet another study, the administration of agents that promote angiogenesis and endothelial cell survival had similar neuroprotective outcomes.
How NCRR Grant Enabled Advance: NCRR COBRE grant (P20 RR15576), provided support to the research project and core facilities.
Public Health Impact: Spinal cord injury (SCI) significantly impacts quality of life and poses a considerable economic burden on those afflicted. Restorative therapies need to be developed to reduce these burdens.
Publication Citation and Link: http://www.ncbi.nlm.nih.gov/pubmed/20181596
PI: Margaret Eggers, M.S., Little Big Horn College, Crow Agency, Montana; Montana State University, Bozeman
Background: The poor well water quality and deteriorating river water quality are impacting community health. The occurrence of disease seems greater on the tribal reservation than in other communities. A collaborative research between Crow Reservation community and academic partners was initiated to assess the risk of exposure to contaminants via domestic and cultural water sources.
Advance: Little is known about how communities and academic partners can effectively work together to conduct “community-based risk assessment,” and rarely have Native American community members written about their perception of the value of the CBPR process to their community, why they would participate in such research, and how research should be conducted in their home community. The Crow Tribal and academic research partners describe their experiences and what they have learned in working together on a creative, collaborative CBPR project and process.
How NCRR Grant Enabled Advance: The Montana INBRE provided initial research funding for the first five years of the project, and continues to support the well water testing costs.
Public Health Impact: This project provides an example of how community members can initiate a risk assessment research in collaboration with academic partners. The partnership improves the quality of the risk assessment and the effectiveness of dissemination to community members.
Publication Citation:. Community-based participatory research in Indian country: improving health through water quality research and awareness. Fam Community Health. 2010 Jul-Sep;33(3):166-74.
Opportunities for Inclusion