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Human Genome Project

Human Genome Project. Animation Overview - Click. What did they do? Why did they do it? What will it mean for humankind?. Brief history of the work…. Proposed in 1985 1988. Initiated and funded by NIH and US Dept. of Energy ($3 billion set aside) 1990. Work begins.

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Human Genome Project

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  1. Human Genome Project Animation Overview - Click • What did they do? • Why did they do it? • What will it mean for humankind?

  2. Brief history of the work… • Proposed in 1985 • 1988. Initiated and funded by NIH and US Dept. of Energy ($3 billion set aside) • 1990. Work begins. • Published in Science and Nature in February, 2001

  3. Goals of HGP • Create map of the 22 human chromosomes, X / Y) • Identify the entire set of genes & map them all to their chromosomes • Determine the nucleotide sequences of the estimated 3 billion base pairs • Analyze genetic variation among humans

  4. Model organisms • Bacteria (E. coli, influenza, several others) • Yeast (Saccharomyces cerevisiae) • Plant (Arabidopsis thaliana) • Fruit fly (Drosophila melanogaster) • Mouse (Mus musculus)

  5. Goals of HGP (cont’d) • Develop new laboratory and computing technologies to make all this possible • Disseminate genome information • Consider ethical, legal, and social issues associated with this research

  6. How they did it… • DNA from 5 humans • 2 males, 3 females • 2 caucasians, one each of asian, african, hispanic • Cut up DNA with restriction enzymes • Sequenced the fragments • Let a supercomputer put the pieces together

  7. Human genome content • 1-2 % codes for protein products • 24% important for translation • 75% “junk” • Repetitive elements • Transposons • Retrotransposons BOOK THAT WROTE ITSELF

  8. Comparative Genomics

  9. Yeast • 70 human genes are known to repair mutations in yeast • Nearly all we know about cell cycle and cancer comes from studies of yeast • Advantages: • fewer genes (6000) • few introns • 31% of yeast genes give same products as human homologues

  10. Drosophila • nearly all we know of how mutations affect gene function come from Drosophila studies • We share 50% of their genes • 61% of genes mutated in 289 human diseases are found in fruit flies • 68% of genes associated with cancers are found in fruit flies

  11. Mouse • known as “mini” humans • Very similar physiological systems • Share 90% of their genes

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