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Unit 5 Part 1: Is cancer in our genes?. Do Now.

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Do now

Unit 5 Part 1: Is cancer in our genes?

Do Now

The function of the BRCA1 protein is to prevent our cells from becoming cancerous. If a cell is dividing too much, the BRCA1 protein can repair the cell so that it undergoes mitosis normally. A portion of the BRCA1 gene (the DNA with instructions on how to make the BRCA1 protein) is shown below.

  • TAC TGA GTT ACA CGA

  • Write out the sequence of mRNA that would be produced during transcription of the BRCA1 gene.


Use the genetic code chart to determine the amino acids that make up this portion of the BRCA1 protein.

What would happen if a person’s BRCA1 protein was not functional?


What is this diagram saying
What is this diagram saying? make up this portion of the BRCA1 protein.

Nucleotide Sequence

Amino Acid Sequence

Protein Shape

Protein Function


What is this diagram saying1
What is this diagram saying? make up this portion of the BRCA1 protein.

Nucleotide Sequence

Amino Acid Sequence

Protein Shape

Protein Function

HIS

LEU

VAL

GLY


Protein shape determines function
Protein make up this portion of the BRCA1 protein.SHAPE determines FUNCTION.


FACT: make up this portion of the BRCA1 protein.Many people with breast cancer have BRCA1 proteins that are the wrong shape or missing amino acids.

How does this happen?

Mutations!


3 Types of Mutations make up this portion of the BRCA1 protein.


Identify the Mutation make up this portion of the BRCA1 protein.

Mutation A: ___________________________

Mutation B: ____________________________

Mutation C: ____________________________


Stop and Jot make up this portion of the BRCA1 protein.

Based on what you have learned thus far, create your own definition of what a “mutation” is


Word of the Day make up this portion of the BRCA1 protein.

Mutation- a random change in the sequence of bases.


Discussion Question make up this portion of the BRCA1 protein.

Insertions and deletions are often called “frameshift mutations” and are far more dangerous than substitution mutations. Why would an insertion or deletion be worse than a substitution?


Cancer Connection make up this portion of the BRCA1 protein.

Compare the beginning sequence of Theresa’s BRCA1 gene to the normal sequence below.

Theresa’s BRCA1 gene: TACTGAGTTACTACGA

Normal BRCA1 gene: TACTGAGTTACACGA


Cancer Connection make up this portion of the BRCA1 protein.

How would her mRNA codons be different than a normal person’s?

How would her amino acid sequence be different than a normal person’s?


Cancer Connection make up this portion of the BRCA1 protein.

State how the BRCA1 protein function would be altered as a result of this mutation.


Cancer Connection make up this portion of the BRCA1 protein.

Synthesize all of the information that you learned today to describe why so many people in Theresa’s family have breast cancer.


Cancer Connection make up this portion of the BRCA1 protein.

Sample data from a patient is shown below. Fill in the patient’s missing codon.


Cancer Connection make up this portion of the BRCA1 protein.

The patient’s BRCA1 protein is normal despite the fact that the BRCA1 gene has a mutation. Explain how this is possible in terms of the genetic code.


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