Immunology of Uveitis (Autoimmune Uveitis). Dr S.H. Zarkesh Department Of Immunology, Medical School, Isfahan University Of Medical Sciences, Isfahan, I.R.IRAN. email: [email protected] Website: www.shef.ac.uk/hamid. Autoimmune Disease Definition.
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This suggests that each role may be involved in different pathways of tolerance, perhaps for distinct types of self antigens
Adaptive/effector T cells from EAU-induced animals can pass the disease to naı¨ve, genetically compatible recipient
Recently, an alternative model to IRBP/CFA-induced uveitis have been developed .
Compared with the classical EAU model induced by active immunization with IRBP or its peptide in CFA,
of many cytokines has been demonstrated in experimental
Uveitis as shown in the next slide.
CsA was first shown to have a therapeutic effect in the rat EAU model before going to clinical trials.
The macrolides FK-506 (tacrolimus) and rapamycin (sirolimus) also target the IL-2 signaling pathway and are effective for some types of uveitis
More recent studies have examined IL-2 receptor-directed therapy with monoclonal antibodies (daclizumab) as an approach
to target activated T cells.
This therapy has shown efficacy in advanced clinical trials.
Interestingly,the possibility that such treatment might actually aggravate
T cell-mediated autoimmunity because IL-2 is necessary for the maintenance and activity of Treg cells (at least in mice)
was not fulfilled.
of daclizumab is complex and incompletely understood,
but includes an enhancement in CD56-bright NK cells with inhibitory function
Since the eye is a small and relatively closed organ, local therapies in the eye are an attractive approach that can obviate systemic side effects.