BONE
This presentation is the property of its rightful owner.
Sponsored Links
1 / 23

BONE PowerPoint PPT Presentation


  • 95 Views
  • Uploaded on
  • Presentation posted in: General

BONE . SSN Histology . The Basics. Specialized connective tissue: mineralized matrix (hydroxyapatite) Type I Collagen; Proteoglycans; Non-collagenous Glycoproteins Functions: Mechanical support Calcium homeostasis Encloses bone marrow. Cells.

Download Presentation

BONE

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Bone

BONE

SSN Histology


The basics

The Basics

  • Specialized connective tissue:

    • mineralized matrix (hydroxyapatite)

      • Type I Collagen; Proteoglycans; Non-collagenous Glycoproteins

  • Functions:

    • Mechanical support

    • Calcium homeostasis

    • Encloses bone marrow


Cells

Cells

Osteoblasts = osteocyte progenitors; secrete ground substance for osteoid

Lab 5, Slide 30


Cells1

Cells

Osteocytes = mature, non-dividing bone cells; enclosed in calcified bone matrix


Cells2

Cells

Osteoclasts = remodeling/ resorption by using lysosomal enzymes


Bone

Cells

Osteoclasts:

Active bone resorption

Limited bone resorption


Mature vs immature bone

Mature vs. Immature Bone

Mature (Lamellar)

Compact (Cortical)

Spongy (Cancellous)

  • w/ Haversian systems

  • w/ trabecular appearance


Mature vs immature bone1

Mature vs. Immature Bone

Immature Bone (Woven)

  • Nonlamellar

  • Found in fetus or following a fracture


Appositional vs interstitial

Appositional vs. Interstitial

  • Appositional = bone growth on pre-existing bone surface

    • Note that bone tissue only undergoes appositional

  • Interstitial = bone growth via new cartilage formation within pre-existing cartilage mass

    • Note that it is cartilage that undergoes interstitial

  • Long Bone Growth:

    • WIDTH --> Appositional(bone)

    • LENGTH --> Interstitial(cartilage)


Endochondral vs intramembranous

Endochondral vs. Intramembranous

Endochondral

Intramembranous


Bone

Endochondral Ossification


Bone

Endochondral Ossification

Zone of Proliferation

Zone of Reserve Cartilage


Bone

Endochondral Ossification

Zone of Hypertrophy

Zone of Proliferation


Bone

Endochondral Ossification

Zone of Calcification

Zone of Resorption


Bone

Preparation of Bone Samples

Ground Bone


Bone

Preparation of Bone Samples

Ground Bone


Bone

Preparation of Bone Samples

Decalcified Bone


Final thoughts

Final Thoughts….

  • Let staining properties guide you

  • Note cellularity; compare size, color, shape, relative quantity of cells

  • Haversian = central to osteon

  • Volkmann’s = perpendicular

  • Think of bone as specialized connective tissue; always in a dynamic state

  • Long bones = endochondral

  • Parietal bones = intramembranous

  • Mnemonic for Endochondral:

    RealPlayersHave CoolRides


Bone

Question 1. . .

Panel A

Panel B


Bone

Questions 2 & 3. . .

Figure A

Figure B


Bone

Questions 4 & 5. ..

Panel B

Panel A


Bone

Question 6. . .


  • Login