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BONE . SSN Histology . The Basics. Specialized connective tissue: mineralized matrix (hydroxyapatite) Type I Collagen; Proteoglycans; Non-collagenous Glycoproteins Functions: Mechanical support Calcium homeostasis Encloses bone marrow. Cells.

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BONE

SSN Histology


The basics
The Basics

  • Specialized connective tissue:

    • mineralized matrix (hydroxyapatite)

      • Type I Collagen; Proteoglycans; Non-collagenous Glycoproteins

  • Functions:

    • Mechanical support

    • Calcium homeostasis

    • Encloses bone marrow


Cells
Cells

Osteoblasts = osteocyte progenitors; secrete ground substance for osteoid

Lab 5, Slide 30


Cells1
Cells

Osteocytes = mature, non-dividing bone cells; enclosed in calcified bone matrix


Cells2
Cells

Osteoclasts = remodeling/ resorption by using lysosomal enzymes


Cells

Osteoclasts:

Active bone resorption

Limited bone resorption


Mature vs immature bone
Mature vs. Immature Bone

Mature (Lamellar)

Compact (Cortical)

Spongy (Cancellous)

  • w/ Haversian systems

  • w/ trabecular appearance


Mature vs immature bone1
Mature vs. Immature Bone

Immature Bone (Woven)

  • Nonlamellar

  • Found in fetus or following a fracture


Appositional vs interstitial
Appositional vs. Interstitial

  • Appositional = bone growth on pre-existing bone surface

    • Note that bone tissue only undergoes appositional

  • Interstitial = bone growth via new cartilage formation within pre-existing cartilage mass

    • Note that it is cartilage that undergoes interstitial

  • Long Bone Growth:

    • WIDTH --> Appositional (bone)

    • LENGTH --> Interstitial (cartilage)


Endochondral vs intramembranous
Endochondral vs. Intramembranous

Endochondral

Intramembranous



Endochondral Ossification

Zone of Proliferation

Zone of Reserve Cartilage


Endochondral Ossification

Zone of Hypertrophy

Zone of Proliferation


Endochondral Ossification

Zone of Calcification

Zone of Resorption




Preparation of Bone Samples

Decalcified Bone


Final thoughts
Final Thoughts….

  • Let staining properties guide you

  • Note cellularity; compare size, color, shape, relative quantity of cells

  • Haversian = central to osteon

  • Volkmann’s = perpendicular

  • Think of bone as specialized connective tissue; always in a dynamic state

  • Long bones = endochondral

  • Parietal bones = intramembranous

  • Mnemonic for Endochondral:

    RealPlayersHave CoolRides


Question 1. . .

Panel A

Panel B


Questions 2 & 3. . .

Figure A

Figure B


Questions 4 & 5. ..

Panel B

Panel A



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