Oxidative decarboxylation
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Oxidative Decarboxylation. Oxidative Decarboxylation. Oxidative Decarboxylation. Pyruvate is converted into acetyl- CoA in order to be brought into the mitochondria. Oxidative Decarboxylation. rxn type: decarboxylation redox synthesis enzyme: decarboxylase dehydrogenase

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Oxidative Decarboxylation

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Oxidative decarboxylation

Oxidative Decarboxylation


Oxidative decarboxylation1

Oxidative Decarboxylation


Oxidative decarboxylation2

Oxidative Decarboxylation

Pyruvate is converted into acetyl-CoAin order to be brought into the mitochondria.


Oxidative decarboxylation3

Oxidative Decarboxylation

rxn type: decarboxylation

redox

synthesis

enzyme: decarboxylase

dehydrogenase

synthase

energy: released


Coenzyme a

Coenzyme A

Coenzyme A is a large organic molecule.

The active functional group is a thiol.

It is also written as

CoA-SH.


Oxidative decarboxylation summary

Oxidative Decarboxylation Summary

  • 2 pyruvate 2 acetyl-CoA

  • 2 CO2 released

  • 2 NADH produced


Kreb cycle

Kreb Cycle


Krebs cycle

Krebs Cycle


Krebs cycle overview

Krebs Cycle Overview

Krebs cycle is a cyclical process to:

  • produce additional CO2 molecules

  • generate more high energy molecules (NADH, FADH2 and ATP)

    Also known as the citric acid cycle and the tricarboxylic acid cycle (TCA).


Krebs cycle1

Krebs Cycle


Krebs cycle step by step

Krebs Cycle: Step by Step

Step 1:

  • join 2 carbon molecule with a 4 carbon molecule

  • rxn type: synthesis

  • enzyme: synthase

  • energy: absorbed


Krebs cycle step by step1

Krebs Cycle: Step by Step

Step 2:

  • rearrangement of atoms with the help of H2O

  • rxn type: isomerization

  • enzyme: isomerase

  • energy: equivalent


Krebs cycle step by step2

Krebs Cycle: Step by Step

Step 3:

  • synthesis of CO2 and NADH

  • rxn type: decarboxylation

    redox

  • enzyme: decarboxylase

    dehydrogenase

  • energy: released


Krebs cycle step by step3

Krebs Cycle: Step by Step

Step 4:

  • CO2 release and energy molecule formation

  • rxn type: decarboxylation

    redox

    synthesis

  • enzyme: decarboxylase

    dehydrogenase

    synthase

  • energy: released


Krebs cycle step by step4

Krebs Cycle: Step by Step

Step 5:

  • ADP phosphorylation to ATP

  • rxn type: substrate-level phosphorylation

    cleavage

  • enzyme: kinase

    lyase

  • energy: released


Krebs cycle step by step5

Krebs Cycle: Step by Step

Step 6:

  • FADH2 (energy molecule) formation

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


Fad fadh 2

FAD / FADH2

  • FAD – flavin adenine dinucleotide (oxidized form)

  • FADH2 – flavin adenine dinucleotide (reduced form)


Krebs cycle step by step6

Krebs Cycle: Step by Step

Step 7:

  • rearranging the molecule for the next reaction

  • rxn type: hydration

  • enzyme: hydrase

  • energy: absorbed


Krebs cycle step by step7

Krebs Cycle: Step by Step

Step 8:

  • energy molecule formation & recreating molecules for Krebs cycle

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


Krebs cycle summary

Krebs Cycle Summary

  • two cycles of Krebs for EACH glucose molecule

  • acetyl-CoA oxaloacetate (per cycle)

  • 2 CO2 released (per cycle)

  • 3 NADH produced (per cycle)

  • 1 FADH2 produced (per cycle)

  • 1 ATP produced (per cycle)


Krebs cycle big picture perspective

Krebs Cycle: Big Picture Perspective

Many of the components of Krebs cycle are used in many other types of metabolic processes.


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