Oxidative decarboxylation
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Oxidative Decarboxylation. Oxidative Decarboxylation. Oxidative Decarboxylation. Pyruvate is converted into acetyl- CoA in order to be brought into the mitochondria. Oxidative Decarboxylation. rxn type: decarboxylation redox synthesis enzyme: decarboxylase dehydrogenase

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Oxidative decarboxylation

Oxidative Decarboxylation


Oxidative decarboxylation1
Oxidative Decarboxylation


Oxidative decarboxylation2
Oxidative Decarboxylation

Pyruvate is converted into acetyl-CoAin order to be brought into the mitochondria.


Oxidative decarboxylation3
Oxidative Decarboxylation

rxn type: decarboxylation

redox

synthesis

enzyme: decarboxylase

dehydrogenase

synthase

energy: released


Coenzyme a
Coenzyme A

Coenzyme A is a large organic molecule.

The active functional group is a thiol.

It is also written as

CoA-SH.


Oxidative decarboxylation summary
Oxidative Decarboxylation Summary

  • 2 pyruvate 2 acetyl-CoA

  • 2 CO2 released

  • 2 NADH produced


Kreb cycle

Kreb Cycle



Krebs cycle overview
Krebs Cycle Overview

Krebs cycle is a cyclical process to:

  • produce additional CO2 molecules

  • generate more high energy molecules (NADH, FADH2 and ATP)

    Also known as the citric acid cycle and the tricarboxylic acid cycle (TCA).



Krebs cycle step by step
Krebs Cycle: Step by Step

Step 1:

  • join 2 carbon molecule with a 4 carbon molecule

  • rxn type: synthesis

  • enzyme: synthase

  • energy: absorbed


Krebs cycle step by step1
Krebs Cycle: Step by Step

Step 2:

  • rearrangement of atoms with the help of H2O

  • rxn type: isomerization

  • enzyme: isomerase

  • energy: equivalent


Krebs cycle step by step2
Krebs Cycle: Step by Step

Step 3:

  • synthesis of CO2 and NADH

  • rxn type: decarboxylation

    redox

  • enzyme: decarboxylase

    dehydrogenase

  • energy: released


Krebs cycle step by step3
Krebs Cycle: Step by Step

Step 4:

  • CO2 release and energy molecule formation

  • rxn type: decarboxylation

    redox

    synthesis

  • enzyme: decarboxylase

    dehydrogenase

    synthase

  • energy: released


Krebs cycle step by step4
Krebs Cycle: Step by Step

Step 5:

  • ADP phosphorylation to ATP

  • rxn type: substrate-level phosphorylation

    cleavage

  • enzyme: kinase

    lyase

  • energy: released


Krebs cycle step by step5
Krebs Cycle: Step by Step

Step 6:

  • FADH2 (energy molecule) formation

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


Fad fadh 2
FAD / FADH2

  • FAD – flavin adenine dinucleotide (oxidized form)

  • FADH2 – flavin adenine dinucleotide (reduced form)


Krebs cycle step by step6
Krebs Cycle: Step by Step

Step 7:

  • rearranging the molecule for the next reaction

  • rxn type: hydration

  • enzyme: hydrase

  • energy: absorbed


Krebs cycle step by step7
Krebs Cycle: Step by Step

Step 8:

  • energy molecule formation & recreating molecules for Krebs cycle

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


Krebs cycle summary
Krebs Cycle Summary

  • two cycles of Krebs for EACH glucose molecule

  • acetyl-CoA oxaloacetate (per cycle)

  • 2 CO2 released (per cycle)

  • 3 NADH produced (per cycle)

  • 1 FADH2 produced (per cycle)

  • 1 ATP produced (per cycle)


Krebs cycle big picture perspective
Krebs Cycle: Big Picture Perspective

Many of the components of Krebs cycle are used in many other types of metabolic processes.


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