Oxidative decarboxylation
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Oxidative Decarboxylation. Oxidative Decarboxylation. Oxidative Decarboxylation. Pyruvate is converted into acetyl- CoA in order to be brought into the mitochondria. Oxidative Decarboxylation. rxn type: decarboxylation redox synthesis enzyme: decarboxylase dehydrogenase

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Oxidative Decarboxylation

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Oxidative Decarboxylation


Oxidative Decarboxylation


Oxidative Decarboxylation

Pyruvate is converted into acetyl-CoAin order to be brought into the mitochondria.


Oxidative Decarboxylation

rxn type: decarboxylation

redox

synthesis

enzyme: decarboxylase

dehydrogenase

synthase

energy: released


Coenzyme A

Coenzyme A is a large organic molecule.

The active functional group is a thiol.

It is also written as

CoA-SH.


Oxidative Decarboxylation Summary

  • 2 pyruvate 2 acetyl-CoA

  • 2 CO2 released

  • 2 NADH produced


Kreb Cycle


Krebs Cycle


Krebs Cycle Overview

Krebs cycle is a cyclical process to:

  • produce additional CO2 molecules

  • generate more high energy molecules (NADH, FADH2 and ATP)

    Also known as the citric acid cycle and the tricarboxylic acid cycle (TCA).


Krebs Cycle


Krebs Cycle: Step by Step

Step 1:

  • join 2 carbon molecule with a 4 carbon molecule

  • rxn type: synthesis

  • enzyme: synthase

  • energy: absorbed


Krebs Cycle: Step by Step

Step 2:

  • rearrangement of atoms with the help of H2O

  • rxn type: isomerization

  • enzyme: isomerase

  • energy: equivalent


Krebs Cycle: Step by Step

Step 3:

  • synthesis of CO2 and NADH

  • rxn type: decarboxylation

    redox

  • enzyme: decarboxylase

    dehydrogenase

  • energy: released


Krebs Cycle: Step by Step

Step 4:

  • CO2 release and energy molecule formation

  • rxn type: decarboxylation

    redox

    synthesis

  • enzyme: decarboxylase

    dehydrogenase

    synthase

  • energy: released


Krebs Cycle: Step by Step

Step 5:

  • ADP phosphorylation to ATP

  • rxn type: substrate-level phosphorylation

    cleavage

  • enzyme: kinase

    lyase

  • energy: released


Krebs Cycle: Step by Step

Step 6:

  • FADH2 (energy molecule) formation

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


FAD / FADH2

  • FAD – flavin adenine dinucleotide (oxidized form)

  • FADH2 – flavin adenine dinucleotide (reduced form)


Krebs Cycle: Step by Step

Step 7:

  • rearranging the molecule for the next reaction

  • rxn type: hydration

  • enzyme: hydrase

  • energy: absorbed


Krebs Cycle: Step by Step

Step 8:

  • energy molecule formation & recreating molecules for Krebs cycle

  • rxn type: redox

  • enzyme: dehydrogenase

  • energy: released


Krebs Cycle Summary

  • two cycles of Krebs for EACH glucose molecule

  • acetyl-CoA oxaloacetate (per cycle)

  • 2 CO2 released (per cycle)

  • 3 NADH produced (per cycle)

  • 1 FADH2 produced (per cycle)

  • 1 ATP produced (per cycle)


Krebs Cycle: Big Picture Perspective

Many of the components of Krebs cycle are used in many other types of metabolic processes.


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