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CNS Stimulants. Analeptics Anorexiants Antidepressants Serotonin agonists. CNS Stimulants: Adverse effects. CVS: Palpitation, tachycardia, hypertension, angina, dyshythmia CNS: Nervousness, restlessness, anxiety Endocrine: Hypoglycemia, hyperglycemia GIT: Nausea, vomiting,diarrhea.

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cns stimulants

CNS Stimulants

Analeptics

Anorexiants

Antidepressants

Serotonin agonists

cns stimulants adverse effects
CNS Stimulants: Adverse effects
  • CVS: Palpitation, tachycardia, hypertension, angina, dyshythmia
  • CNS: Nervousness, restlessness, anxiety
  • Endocrine: Hypoglycemia, hyperglycemia
  • GIT: Nausea, vomiting,diarrhea
analeptic
Analeptic
  • Used to stimulate respiration when natural reflex is lost
  • H-cholinomimetic (reflex analeptic)
  • Central analeptic (Aminophyllin, theophylline,Caffeine, Doxapram)
did you know
Did You Know?
  • Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans. Caffeine is sometimes called guaranine when found in guarana, mateine when found in mate, and theine when found in tea. It is found in the leaves and beans of the coffee plant, in tea, yerba mate, and guarana berries, and in small quantities in cocoa, the kola nut and the Yaupon Holly. Overall, caffeine is found in the beans, leaves, and fruit of over 60 plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
chemical properties
Chemical Properties

Molar Mass = 194.19 g mol−1

Density: 1.2 g/cm³

Phase: Solid

Melting Point: 237 °C

Boiling Point: 178 °C

uses of caffeine
Uses of Caffeine
  • Caffeine is a central nervous system (CNS) stimulant, having the effect of temporarily warding off drowsiness and restoring alertness. Beverages containing caffeine, such as coffee, tea, soft drinks and energy drinks enjoy great popularity: caffeine is the world\'s most widely consumed psychoactive substance. In North America, 90% of adults consume caffeine daily.
metabolizing of caffeine
Metabolizing Of Caffeine
  • Caffeine is completely absorbed by the stomach and small intestine within 45 minutes of ingestion. After ingestion it is distributed throughout all tissues of the body and is eliminated by first-order kinetics. The half-life of caffeine varies widely among individuals according to such factors as age, liver function, pregnancy, some concurrent medications, and the level of enzymes in the liver needed for caffeine metabolism. In healthy adults, caffeine\'s half-life is approximately 3-4 hours. In women taking oral contraceptives this is increased to 5-10 hours, and in pregnant women the half-life is roughly 9-11 hours. Caffeine can accumulate in individuals with severe liver disease when its half-life can increase to 96 hours.
caffeine
Caffeine
  • AP
  • Hate rate
  • Respiratory stimulation
  • Adjunctive effect
doxapram
Doxapram
  • over dosage of CNS depressant
  • COPD (chronic obstructive pulmonary disease
  • Respiratory depression in postoperative recovery period
doxapram contraindication
Doxapram: Contraindication
  • Newborn
  • Epilepsy
  • Hypertension
  • Stroke
amphetamines
Amphetamines
  • Produce mood elevation or euphoria, increase mental alertness and capacity for work, decrease fatigue and drowsiness, prolong wakefulness.
amphetamines usage
Amphetamines usage
  • Narcolepsy
  • ADHD (attention-deficit/hyperactivity disorder
amphetamines1
Amphetamines
  • Tolerance
  • Psychological dependence
  • High abuse potential (under Control Substance Act
methylxanthines
Methylxanthines
  • COPD (chronic obstructive pulmonary disease
  • Respiratory depression in postoperative recovery period
anorexants
Anorexants
  • Central acting (Benzphetamine, diethylpropion, Sibutramine)
  • Metabolism acting (orlistat)
antidepressants
Antidepressants
  • Used to treat depression
  • Depression, common feelings
    • Pessimism
    • Worry
    • Intense sadness
    • Loss of concentration
    • Slowing of mental processes
    • Problems with eating and sleeping
serotonin agonist sumatriptan
Serotonin agonist (Sumatriptan)
  • Treatment of migraine
antidepressants common symptoms of depression
Loss of interest in usual activities

Low self-esteem

Self-pity

Significant weight loss or gain

Insomnia or hypersomnia

Extreme restlessness

Loss of energy

Feelings of worthlessness

Diminished ability to think

Feelings of guilt

Recurrent thoughts of death

Suicide attempts

AntidepressantsCommon Symptoms of Depression
antidepressants1
Antidepressants

Depression

  • Women are affected more often than men
  • When men are affected, it is usually later in life
  • Levels of neurotransmitters in the brain may be a causative factor
mood disorders
Mood Disorders
  • Mania
  • Bipolar Disorder
  • Unipolar Disorder
mood disorders1
Mood Disorders
  • Mania

Mood of extreme excitement, excessive elation, hyperactivity, agitation, and increased psychomotor activity

  • Bipolar Disorder
  • Unipolar Disorder
mood disorders2
Mood Disorders
  • Mania
  • Bipolar Disorder

Mood swings alternate between major depression and mania

  • Unipolar Disorder
mood disorders3
Mood Disorders
  • Mania
  • Bipolar Disorder
  • Unipolar Disorder

Major depression with no previous occurrence of mania

treatment for depression
Treatment for Depression

Electroconvulsive Therapy

  • Introduction of brief, but convulsive electrical stimulation through the brain
  • Can induce seizures
  • Effective for major and delusional depression
antidepressants2
Antidepressants
  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Cyclic Antidepressants
  • Monoamine Oxidase Inhibitors (MAOIs)
antidepressants3
Antidepressants

Selective Serotonin Reuptake Inhibitors (SSRIs)

  • Block the reuptake of serotonin, with little effect on norepinephrine
  • Fewer side effects than older meds
treatments
Treatments

Cyclic Antidepressants

  • Two Types
    • Tricyclic antidepressants (TCAs)
    • Tetracyclic antidepressants
  • Prevent reuptake of norepinephrine and/or serotonin
  • Agents in this class differ in adverse effects, cost, and response
treatments1
Treatments

Monoamine Oxidase Inhibitors (MAOIs)

Allows for buildup of norepinephrine at the synapse

ssris for depression

Drug List

SSRIs for Depression
  • citalopram (Celexa)
  • escitalopram (Lexapro)
  • fluoxetine (Prozac, Sarafem)
  • fluvoxamine
  • paroxetine (Paxil)
  • sertraline (Zoloft)
  • venlafaxine (Effexor)
dispensing issues
Dispensing Issues

Look-Alike Drugs

  • Prozac and Proscar (urinary drug)
  • Zoloft and Zocor (high cholesterol)
  • Celexa and Cerebyx (seizures) and Celebrex (arthritis)

Warning!

ssri dispensing issues
SSRIDispensing Issues
  • Do not discontinue abruptly
  • Alcohol consumption should be avoided while taking these medications

Warning!

fluoxetine prozac
fluoxetine (Prozac)
  • Indicated for major depression and obsessive-compulsive disorder (OCD)
  • Anorexia is a possible adverse effect
  • Take in the morning to avoid insomnia
paroxetine paxil
paroxetine (Paxil)
  • Indicated for depression, obsessive-compulsive disorder, and panic disorder
venlafaxine effexor
venlafaxine (Effexor)
  • Blocks reuptake of serotonin and norepinephrine
  • Indicated for depression
  • May cause increase in blood pressure and blurred vision
sertraline zoloft
sertraline (Zoloft)
  • Indicated for depression and obsessive-compulsive disorder
  • Primary side effect is nausea
  • May also cause drowsiness
citalopram celexa
citalopram (Celexa)
  • Indicated for depression and obsessive-compulsive disorder
  • Minimal drug interactions
escitalopram lexapro
escitalopram (Lexapro)
  • Similar to Celexa
  • More potent with fewer side effects
cyclic antidepressants

Drug List

Cyclic Antidepressants

Tricyclic

  • amitriptyline (Elavil)
  • clomipramine (Anafranil)
  • desipramine (Norpramin)
  • doxepin (Sinequan)
  • imipramine (Tofranil)
cyclic antidepressants1

Drug List

Cyclic Antidepressants

Tricyclic

  • nortriptyline (Aventyl, Pamelor)
  • protriptyline (Vivactil)
  • trimipramine (Surmontil)

Tetracyclic

  • maprotiline
tricyclic antidepressants dispensing issues
Tricyclic Antidepressants Dispensing Issues
  • Improvements are usually seen in 10 to 21 days
  • Can be cardiotoxic in high doses
  • May cause postural hypotension

Warning!

tricyclic antidepressants dispensing issues1
Tricyclic AntidepressantsDispensing Issues

Do not discontinue abruptly.

Warning!

cyclic antidepressants side effects
Cyclic Antidepressants Side Effects
  • Sedation is common, but tolerance usually occurs
  • Have many anticholinergic effects
discussion
Discussion

Why would cyclic antidepressants be prescribed for bed wetting in children?

discussion1
Discussion

Why would TCAs be prescribed for bed wetting in children?

Answer

They may be prescribed because of their anticholinergic side effects.

maois

Drug List

MAOIs
  • phenelzine (Nardil)
  • selegiline (Eldepryl)
  • tranylcypromine (Parnate)
maoi dispensing issues
MAOI Dispensing Issues

Be cautious of many interactions with foods such as aged cheeses, concentrated yeast extracts, pickled fish, sauerkraut, broad bean pods, chocolate, and alcohol.

Warning!

maoi dispensing issues1
MAOI Dispensing Issues

If changing to another class of antidepressant, patient must have a two-week “wash out” period before starting the new medication.

Warning!

other antidepressants

Drug List

Other Antidepressants
  • bupropion (Wellbutrin, Zyban)
  • mirtazapine (Remeron)
  • trazodone (Desyrel)
trazodone desyrel
trazodone (Desyrel)
  • Prevents reuptake of serotonin and norepinephrine
  • Has a better side effect profile than TCAs
  • Caution: possible interaction with Ginkgo
bupropion wellbutrin zyban
bupropion (Wellbutrin, Zyban)
  • Dopamine-uptake inhibitor
  • Does not cause sedation, blood pressure changes, or ECG changes
  • Do not discontinue abruptly
  • Approved in the aid of smoking cessation
other antidepressant dispensing issues
Other Antidepressant Dispensing Issues
  • Wellbutrin SR = BID dosing
  • Wellbutrin XL = QD dosing

Warning!

bipolar disorders
Bipolar Disorders

Signs or Symptoms

  • Decreased need for sleep
  • Elevated or irritable mood
  • Excessive involvement in pleasurable activities with a big potential for painful consequences
  • Grandiose ideas
  • Pressure to keep talking
  • Racing thoughts
discussion2
Discussion

What is the drug of choice for treating bipolar disorders?

discussion3
Discussion

What is the drug of choice for treating bipolar disorders?

Answer

Lithium

discussion4
Discussion

What is the two-fold objective of drug therapy for bipolar disorder?

discussion5
Discussion

What is the two-fold objective of drug therapy for bipolar disorder?

Answer

Treat acute episodes

Prevent subsequent attacks

drugs to treat bipolar disorders

Drug List

Drugs to Treat Bipolar Disorders
  • carbamazepine (Epitol, Tegretol)
  • divalproex (Depakote)
  • lithium (Eskalith, Lithobid)
  • olanzapine-fluoxetine (Symbyax)
  • valproic acid (Depakene)
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