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Exercise – Newest Medication for Parkinson’s Disease ?

Exercise – Newest Medication for Parkinson’s Disease ?. Co-Founder -Program Development Coordinator OhioHealth Delay the Disease. David Zid, BA ACE APG. Jackie Russell, RN BSN CNOR. Co-Founder –Director, Movement Disorder /Musculoskeletal Wellness

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Exercise – Newest Medication for Parkinson’s Disease ?

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  1. Exercise – Newest Medication for Parkinson’s Disease ? Co-Founder -Program Development Coordinator OhioHealth Delay the Disease David Zid, BA ACE APG Jackie Russell, RN BSN CNOR Co-Founder –Director, Movement Disorder /Musculoskeletal Wellness OhioHealth Delay the Disease

  2. Neuroplasticity is defined as: PreTest Question #1 • The brain’s ability to fight off bacteria • The brain’s ability to reorganize itself by forming new nerve connections to “rewire” and relearn • Destruction of an existing nerve pathway • Occurs in the brain only during childhood years to aid in learning

  3. Exercise appears to prime the brain for the neuroplastic process of relearning due to: PreTest Question #2 • Aerobic activity slows the ability of a neuron to perform axonal sprouting • Exercise clears the brain of existing neuronal pathways to prepare for relearning • Improves immunosuppressive response in the brain • Exercise enhances upregulation (increased production) of neurotrophic factor, BDNF which aids synaptic regrowth

  4. SLIDE IS PLACE HOLDER FOR VIDEO Kathy Before and After…..

  5. Don’t Sit ! Be Active for Brain Health

  6. Delay the DiseaseTMis an evidenced-based fitness program for people living with Parkinson’s disease. The program is designed to empower participants by optimizing their physical function and helping to delay the progression of symptoms.

  7. The Team David Zid Jackie Russell Rocco Presutti

  8. Did you know that the brain is plastic?

  9. Neuroplasticity • Brain’s ability to reorganize itself by forming new nerve connections. • Life-long process • Modification of existing nerve pathways so brain becomes more efficient. • Exercise enhances this process by upregulating (increased production) of neurotrophic factor, BDNF. “MIRACLE GRO”. • BDNF enhances synaptic regrowth/rewiring/relearning. • NEUROPROTECTION • Rigorous/Intense ? Disease Reversal ? NEUROGENESIS

  10. “Miracle Gro”-BDNF, fertilizes axonal sprouting.

  11. Brain Repair Axonal sprouting - undamaged nerve networks grow new nerve endings to reconnect damaged neurons Rewiring -defines new nerve pathways to accomplish lost functions. Brain Repair -behaviors that were lost due to disease may be relearned! (Memory, gait, speech)

  12. Smith, A; Goldsworthy, M; The influence of a single bout of aerobic exercise on short-interval intracortical excitability. Exp Brain Research 2/2014 • 26 participants in mid 30s • 30 mins high intensity cycle • Cortical inhibition before and after • Measured hand muscle excitability • Less inhibition and more hand excitability A single bout of exercise may promote cortical environment that is optimal for plasticity. After Cardio

  13. Aerobic Exercise Primes the Brain for Learning High Intensity is needed for optimal improvement of symptoms. (JAMA Neurology Dec. 11, 2017 – Corsos DM et al)

  14. PD PrevalenceThe largest U.S. study of the epidemiology of Parkinson's disease shows the highest prevalence (13,800 cases or more per 100,000 residents ages 65 and older) in red. Neuroepidemiology 2010/Willis AW, et al • 1-3 million currently diagnosed in the US • 1.6% of the population 100,000 new cases diagnosed annually Kowal SL et al.. 2013

  15. Recipe for Success:Intensity– aerobic, slightly breathlessSpecific– practice what you want to improve, stay engaged, repeat perfect behaviorOngoing–daily is bestComplex /Difficult – multitasking, motor and cognitive Cardio Brain Core

  16. DTD 12 Week CycleBi-weekly classes x 12 weeks: EducationOutcome Measures : Pre- and Post- TestingFunctional Measures /Quality of Life toolClinically significant improvements in functional mobility, reduced risk for falling, enhanced quality of life, increased caregiver comfort.

  17. The Effects of a formal exercise program on Parkinson’s DiseaseParkinsonism and Related Disorders, 2014A Park, D Zid, J Russell, A. Malone, A. Rendon, X Li PUBLISHED Conclusions: This group exercise program had a significant effect on the symptoms of depression. Group exercise programs for PD are feasible with minimal drop out and and excellent adherence. Positive environment of group exercise improved attitudes, fostered optimism, and was a positive force for the patient and the circle of support.

  18. REPEAT PERFECT BEHAVIOR (after cardio) Fight Rigidity/Tremor Rotation / Weight lifting cycle Improve Balance/Gait “John Wayne wide”, balance / 10 big loud steps/ backwards walking Improve Posture Back or seated line up, postural stretch Multi Tasking/ Cognitive Agility ladder / multi-task walking drill / wall drill / driver lunge

  19. NATIONAL CLASSES Illinois Idaho Iowa Indiana New Jersey W.Va Nevada Ohio Nebraska California New York Michigan Connecticut Massachusetts Pennsylvania N. Carolina Florida Ontario, Canada Community–Based PD Exercise Classes since 2006 Educating Healthcare Professionals – next course April 14-15 Educating Caregivers Disease Specific Education Home Care Agencies / Rehab Companies Research Community Awareness Seminars 90,000 contacts per year nationally – 280 trained per day

  20. “Hope” is the thing with feathers –That perches in the soul –And sings the tune without the words –And never stops - at all –~Emily Dickinson

  21. Neuroplasticity is defined as: Post Test Question #1 • The brain’s ability to fight off bacteria • The brain’s ability to reorganize itself by forming new nerve connections to “rewire” and relearn • Destruction of an existing nerve pathway • Occurs in the brain only during childhood years to aid in learning

  22. Exercise appears to prime the brain for the neuroplastic process of relearning due to: Post Test Question #2 • Aerobic activity slows the ability of a neuron to perform axonal sprouting • Exercise clears the brain of existing neuronal pathways to prepare for relearning • Improves immunosuppressive response in the brain • Exercise enhances upregulation (increased production) of neurotrophic factor, BDNF which aids synaptic regrowth

  23. Jackie Russell, RN BSN CNOR Co-Founder Delay the Disease Jackie Russell, RN BSN CNOR Co-Founder Delay the Disease Jackie.Russell@ohiohealth.com 614-975-5874 (cell)975-5874 (cell) www.delaythedisease.com Thank You David Zid Jackie Russell

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