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The Cancer Prevention Study – 3 Epidemiology Research Program American Cancer Society

The Cancer Prevention Study – 3 Epidemiology Research Program American Cancer Society. “ Everyone knows that cigarette smoking causes lung cancer. Few realize that it took three years, 22,000 volunteers, and 188,000 study participants to prove it .” Meghan Murphy, The Greeley Tribune; 2007.

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The Cancer Prevention Study – 3 Epidemiology Research Program American Cancer Society

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  1. The Cancer Prevention Study – 3 Epidemiology Research Program American Cancer Society

  2. “Everyone knows that cigarette smoking causes lung cancer. Few realize that it took three years, 22,000 volunteers, and 188,000 study participants to prove it.”Meghan Murphy, The Greeley Tribune; 2007

  3. ACS Cancer Prevention Studies The Society has been conducting large-scale, nationwide population studies to examine the causes of cancer and how to prevent it for nearly 60 years. CPS-I 1959-72 1,000,000 Both 68,000 25 Mortality Smoking, obesity CPS-II 1982- 1,200,000 Both 77,000 50 Mortality (& incidence) Multiple Years Participants Sex Volunteers States Cancer endpoints Research Emphases Hammond-Horn 1952-55 188,000 Men 22,000 9 Mortality Smoking

  4. Tobacco Control and Mortality 1964 Surgeon General’s Report Cigarette consumption Lung cancerMen Lung cancerwomen CPS-I CPS-II Hammond-Horn Study

  5. Obesity and Mortality J Chron Dis, 1979

  6. Physical Activity and Cancer

  7. Diet and Cancer

  8. Individuals: Maintain a healthy weight throughout life. Adopt a physically active lifestyle. Consume a healthy diet, with an emphasis on plant sources. If you drink alcoholic beverages, limit consumption. 2006 Guidelines on Nutrition and Physical Activity for Cancer Prevention

  9. Major Contributions to Public Health • 21 U.S. Surgeon General Reports on Smoking & Cancer. • Confirm relationship of 2nd hand smoke with lung cancer & heart disease, helping to motivate smoke-free laws. • Found that low tar/nicotine cigarettes don’t reduce lung cancer risk. • First epidemiological study that overweight/obesity shortens longevity. • Landmark paper linking obesity to increased death rates from at least ten cancer sites, including colon and post-menopausal breast cancer. • First US epidemiologic study showing sitting time shortens longevity. • Major contributions to IARC Monographs, WCRF/AICR Reports on PA, nutrition and obesity • Discovery of the link between aspirin use and lower risk of colon cancer. • Air pollution (small particulates/ozone) increase death rates from heart and lung conditions; motivate the EPA to propose stringent limits on air pollution.

  10. > 450 Reports, Monographs, Peer-Reviewed Publications Have Contributed to Falling Cancer Death Rates Men 21% Decrease from 1990 through 2006 12% Decrease from 1991 through 2006 Women Jemal et al., Annual Report to Nation 2009

  11. Cancer Prevention Study – 3 CPS-I 1959-72 1,000,000 Both 68,000 25 Mortality Smoking, obesity CPS-II 1982- 1,200,000 Both 77,000 50 Mortality (& incidence) Multiple CPS-3 2006- 300,000 Both 25,000 35 Mortality & incidence Multiple Years Participants Sex Volunteers States Cancer endpoints Research Emphases Hammond-Horn 1952-55 188,000 Men 22,000 9 Mortality Smoking

  12. Why Do We Need CPS-3? To track the evolution of changes in obesity, nutrition, activity (and smoking) and their impact on morbidity and mortality To identify new risk factors for cancer due to changes in environment, lifestyles, medications and new technologies To expand our knowledge of cancer risk factors in diverse populations (e.g., race/ethnicity, SES) To improve understanding of cancer biology and etiology To improve risk prediction To have a contemporary national resource in the US as most new large studies are overseas

  13. What Makes CPS-3 Different from OtherCancer Prevention Studies? • Higher proportion of younger adults (e.g., 60% are 30-49 yrs) • Blood draw at baseline on all participants • Physical assessment at baseline (e.g., waist circumference) • Detailed medication history at baseline • Use of electronic technologies for data collection • Greater ethnic/racial diversity

  14. CPS-3 Goals Operational Enroll a diverse group (of 300,000) men and women aged 30-65 years with no prior history of cancer At least 25% minority participation Geographic diversity Blood specimens at enrollment Scientific Examine a wide spectrum of lifestyle, behavioral, environmental, and genetic factors in relation to cancer risk and mortality Study gene x environment interactions in cancer risk and mortality Identify and/or validate early markers of disease

  15. Venues to Reach 300,000 by Dec 2013 • Nationwide-wide engagement to support enrollment • Utilize a combination of venues: • Relay For Life and other event-based enrollment • Open community enrollment in select markets • Corporate/worksite enrollment • Hospital-based enrollment • Targeted recruitment to increase minority & male participation utilizing all venues

  16. Relay Based Enrollment Initial enrollment Part One (in person) Consent and brief survey Waist circumference measurements Small blood sample Part Two (at home paper or electronic) Comprehensive baseline survey Long-term follow-up Repeat surveys every few years Annual newsletter to participants

  17. Other NON-Relay Based Enrollments Initial enrollment Part One (at home electronic) Schedule appointment Comprehensive baseline survey Part Two (on site during appointment) Consent and short survey Waist circumference Small blood sample Long-term follow-up Repeat surveys every few years Annual newsletter to participants

  18. Protection of CPS-3 Participants • Approval and oversight by Emory University Institutional Review Board • Data are de-identified by assignment of unique study ID • Limited access to study data by authorized research personnel • All CPS-3 research staff, volunteers and vendors sign confidentiality forms • Participant identity will never be disclosed within or outside ACS, without participant approval • Individual results will not be shared with participants or their family, physicians, employers, insurance companies or other third parties • Privacy and confidentiality are addressed on the CPS-3 informed consent form • Note: At corporate sites, employees should use personal email if concerned about the possibility of corporate email monitoring

  19. Where Are We Now? Over 180,000 participants in 34 states plus Puerto Rico

  20. CPS-3: Benefits Beyond the Science Engages staff Society-wide in research Builds long-term volunteer and donor relationships Empowers survivors and their caregivers Enriches corporate partnerships Enhances community relationships and presence Positively impacts fundraising Brings wide-scale media and publicity

  21. Cancer Prevention Study-3: Leading the Way to a World with Less Cancer & More Birthdays… “I have already signed up to participate myself, as this study offers a unique opportunity to be a part of some of the most pioneering medical advances of our time.” Dr. John Seffrin, American Cancer Society National CEO

  22. For more information: Visit www.cancer.org/cps3 Call toll-free 1-888-604-5888 Email us at cps3@cancer.org Become a fan at www.facebook.com/supportCPS3

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