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The DANAMI-2 Trial

The DANAMI-2 Trial. Danish Trial in Acute Myocardial Infarction-2 Presented at the American College of Cardiology 51st Annual Scientific Session Atlanta, GA Dr. Henning Rud Andersen for the DANAMI-2 investigators. DANAMI-2: Study Design.

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The DANAMI-2 Trial

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  1. The DANAMI-2 Trial Danish Trial in Acute Myocardial Infarction-2 Presented at theAmerican College of Cardiology 51st Annual Scientific Session Atlanta, GA Dr. Henning Rud Andersen for the DANAMI-2 investigators

  2. DANAMI-2: Study Design High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs 5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs Primary PCI without transfer (n=223) Primary PCI with transfer (n=567) Lytic therapy Front-loaded tPA 100 mg (n=782) Death / MI / Stroke at 30 Days Stopped early by safety and efficacy committee

  3. DANAMI-2: Centers

  4. DANAMI-2: Primary Results Non-Transfer Sites Transfer Sites Combined P=0.048 P=0.0003 P=0.002 RRR 40% RRR 45% RRR 45% Death / MI / Stroke (%) Lytic Primary PCI Lytic Primary PCI Primary PCI Lytic

  5. DANAMI-2: Results Stroke Death Recurrent MI P=0.15 P<0.0001 P=0.35 Lytic Primary PCI Lytic Primary PCI Primary PCI Lytic

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