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Case 2007-1971. Ellen M Binder. Signalment & History. Number 200 18-month old female brown and white Boer goat Transported from NC to VA 1 week ago Bred within last 2-3 weeks Vaccinated within last week Other goats (4) normal Clinical Signs Lethargy, depression

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Case 2007 1971

Case 2007-1971

Ellen M Binder

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Signalment history
Signalment & History

  • Number 200

    • 18-month old female brown and white Boer goat

  • Transported from NC to VA 1 week ago

    • Bred within last 2-3 weeks

    • Vaccinated within last week

    • Other goats (4) normal

  • Clinical Signs

    • Lethargy, depression

    • Mucous membranes pale and grey

    • Pigmenturia

    • Neurologic

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Cbc chemistry
CBC & Chemistry

  • Anemia

  • Leukocytosis

  • Azotemia

  • Liver and muscle enzymes increased

  • Urinalysis

    • Proteinuria

    • Pigmenturia

    • Hematuria

  • Fecal Egg Count

  • Treatment

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Differential diagnoses
Differential Diagnoses

  • Copper Toxicosis

  • Infectious

    • Leptospira

  • Plant toxicosis

  • Unknown toxin/infection

  • Myopoathy

Copper (serum): 2.6ppm

Lead (blood): none detected

Negative

No methemoglobinemia

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Kidney
Kidney

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Kidney h e 200x
Kidney: H&E (200x)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Kidney h e 400x
Kidney: H&E (400x)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Kidney special stains
Kidney: special stains

Prussian Blue

Halls

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Steiner’s

Rhodanine


Kidney prussian blue
Kidney: Prussian Blue (+)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Liver h e 100x
Liver: H&E (100x)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Liver h e 200x
Liver: H&E (200x)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Liver h e 400x
Liver: H&E (400x)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Liver special stains
Liver: special stains

Prussian Blue

Halls

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only

Rhodanine


Liver halls
Liver: Halls (+)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Liver rhodanine
Liver: Rhodanine (+)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Morphologic diagnoses
Morphologic Diagnoses:

  • Kidney, acute tubular necrosis, diffuse, marked, with hemoglobin tubular casts and multifocal interstitial nephritis.

  • Liver, hepatitis, periportal and centrilobular, moderate, with copper accumulation, hepatocellular necrosis and cholestasis.

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Copper toxicosis
Copper Toxicosis

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Copper toxicosis1
Copper Toxicosis

  • Stressor precipitates sudden release of Cu

    • Hepatic necrosis

    • Hemolytic crisis

  • Other species

    • Cattle

    • Pigs

    • Dogs: Bedlington, WHWT, & Skye terriers

    • Siamese cat (single case)

    • Humans (Wilson disease)

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Copper toxicosis in a dairy goat herd cornish j angelos j puschner b miller g george l 2007
COPPER TOXICOSIS IN A DAIRY GOAT HERD. Cornish J, Angelos J, Puschner B, Miller G, George L., 2007

  • 400 mixed breed dairy goats

  • Decrease in milk production and increased mortality rate

    • 9 deaths within a 1 month period

    • Clinical signs only in lactating goats

    • Anorexia, recumbency, neurologic abnormalities and death

    • AST, GGT and Total bilirubin: elevated

    • No evidence of hemolysis

    • Had been fed mineral mix containing 3,050 ppm copper for the past 9 months

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


Acknowledgments
Acknowledgments

  • Histology technicians

  • Co-authors:

    • Natalie Crawford, D Phillip Sponenberg, Rachel Tan, Flavia Lepene  

References

Adam SEI, Wasfi LA, Chronic copper toxicity in Nubian goats. J Comp Pathol 1977;87:623-627.

Cornish J, Angelos J, Puschner B, Miller G, George L. Copper toxicosis in a dairy goat herd. JAVMA 2007; 231,4:586-589.

Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. Ed. M Grant Maxie. Saunders Ltd. 2:379-381.

Solaiman SG, Maloney MA, Qureshi MA, et al. Effects of high copper supplements on performance, health, plasma copper and enzymes in goats. Small Rumin Res 2001;41:127-139.

Soli NE, Nafstad I. Effects of daily oral administration of copper to goats. Acta Vet Scand 1978; 19:561-568.

Presented at SEVPAC 2008 – Permission granted for use on SEVPAC website only


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