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Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults

Featured Article :. Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults. Peter T. Campbell, Ph.D., Christina C. Newton, M.S.P.H., Alpa V. Patel, Ph.D., Eric J. Jacobs, Ph.D., Susan M. Gapstur, Ph.D. Diabetes Care Volume 35: 1835-1844 September, 2012.

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Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults

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  1. Featured Article: Diabetes and Cause-Specific Mortality in a Prospective Cohort of One Million U.S. Adults Peter T. Campbell, Ph.D., Christina C. Newton, M.S.P.H., Alpa V. Patel, Ph.D., Eric J. Jacobs, Ph.D., Susan M. Gapstur, Ph.D. Diabetes Care Volume 35: 1835-1844 September, 2012

  2. Study Objective • To examine the association of diabetes on cause-specific mortality, including deaths from specific cancers Campbell P et al. Diabetes Care 2012;35:1835-1844

  3. Study Design & Methods • Prospective cohort included 1,053,831 U.S. adults without cancer at baseline, enrolled in the Cancer Prevention Study-II in 1982 and followed for mortality until December 2008 • At baseline, participants completed a self-administered questionnaire including information on diabetes, smoking, physical activity, height, and weight • Multivariable-adjusted relative risks (RRs) (95% CI) were estimated using the Cox proportional hazards regression Campbell P et al. Diabetes Care 2012;35:1835-1844

  4. Results • During 26 years of follow-up, 243,051 men and 222,109 women died • In multivariable models that controlled for age, BMI, and other variables, diabetes was associated with higher risk of all-cause mortality (women RR 1.90 [95% CI 1.87–1.93]; men 1.73 [1.70–1.75]) Campbell P et al. Diabetes Care 2012;35:1835-1844

  5. Results • Diabetes associated with higher risk of death from the following cancers: • Among women: • Liver (1.40 [1.05–1.86]) • Pancreas (1.31 [1.14–1.51]) • Endometrium (1.33 [1.08–1.65]) • Colon (1.18 [1.04–1.33]) • Breast (1.16 [1.03–1.29]) • Among men: • Breast (4.20 [2.20–8.04]) • Liver (2.26 [1.89–2.70]) • Oral cavity and pharynx (1.44 [1.07–1.94]) • Pancreas (1.40 [1.23–1.59]) • Bladder (1.22 [1.01–1.47]) • Colon (1.15 [1.03–1.29]) • (Inversely) prostate (0.88 [0.79–0.97]) Campbell P et al. Diabetes Care 2012;35:1835-1844

  6. Results • Diabetes associated with higher risks of death involving the circulatory system, respiratory system, digestive system, genitourinary system, and external causes/accidental deaths Campbell P et al. Diabetes Care 2012;35:1835-1844

  7. Campbell P et al. Diabetes Care 2012;35:1835-1844

  8. Campbell P et al. Diabetes Care 2012;35:1835-1844

  9. Campbell P et al. Diabetes Care 2012;35:1835-1844

  10. Campbell P et al. Diabetes Care 2012;35:1835-1844

  11. Campbell P et al. Diabetes Care 2012;35:1835-1844

  12. Campbell P et al. Diabetes Care 2012;35:1835-1844

  13. Conclusions • Diabetes associated with higher risk of death for many diseases, including several specific forms of cancer Campbell P et al. Diabetes Care 2012;35:1835-1844

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