Smallpox vaccine in combination with ST-246. Robert Jordan, Ph.D. SIGA Technologies, Inc. FDA – Public HearingMay 17, 2007. Sentinel Case. Exposure. Rash……………Death. Fever. Incubation. ~ 14 days. ~ 21 days. ~ 3 days. ACAM-2000. MVA. ST-246. Golden Hours. ST-246.
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Smallpox vaccine in combination with ST-246
Robert Jordan, Ph.D.
SIGA Technologies, Inc
FDA – Public HearingMay 17, 2007
~ 14 days
~ 21 days
~ 3 days
ST-246 Progress to Date
orthopoxvirus induced pathogenesis and/or disease
primate model of orthopoxvirus disease
treatment of smallpox approved
ST-246Target is F13L
*Animals infected in presence of ST-246 develop a protective immune response
I.N. vaccinia virus challenge in mice
Uses for the ST-246 Smallpox Antiviral
Dryvax Dermal Challenge/SIGA-246 Treatment