Gene Therapy and Genetic Engineering

1. Gene Therapyand Genetic Engineering

2. Your Goals: • Create a Concept Map to organize what you know about gene therapy. • Use the Learn.Genetics gene therapy website to help you. • Integrate what you have learned about Genetic Engineering into your Gene Therapy Concept Map. • Gene Therapy Vector Engineering Project.

3. Concept Map Overview • A concept map is a technique used to organize information or thoughts. • Concept maps allow you to organize lots of information into a form that is easily understood. • Concept maps allow you to visualize connections within the information.

4. Gene Therapy Word List • Integrating the gene • Fit inside vectors • Keys to success • Viruses • Candidate diseases • Liposomes • Procedure • Integration into the germline • Risks/Challenges • ex vivo • Targeting the right tissue • Immune response • Vectors • Single gene disorders • Naked DNA • Activating the gene • Disruption of existing genes • in vivo

5. Gene Therapy AND Genetic Engineering Word List • Plasmids • Hemophilia • Identical DNA copy • Recombinant DNA tools • ADA Deficiency • Restriction Enzymes • Adeno Associated virus • Sickle Cell Anemia • Herpes Simplex Virus • Identical organism copy • Ligase • Huntingtons Disease • Retrovirus • Cloning • Adenovirus

6. Creating a Concept Map Step 1 • Start by placing your Main Idea in the center circle or graphic. Step 2 • Decide which of the choices are your Large Topics and place them in a circle around your Main Idea. • Draw lines connecting the Main Idea and the Large Topics.

7. Large topic Large topic Large topic Large topic

8. Creating a Concept Map Step 3 • Decide which Subtopics belong with each Large Topic and place them near the appropriate branch. • Cut the Topics out of the Word List so you can easily rearrange them until you have it right. • Paste your Concept Map to your poster.

9. Concept Map! subtopics Large topic Large topic subtopics Large topic Large topic subtopics subtopics