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甜草化学成分研究 PowerPoint PPT Presentation


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甜草化学成分研究. 答辩人:刘文基 指导教师:李厚金 副教授 中山大学有机所. 内容提要. 一、前言 二、研究目的 三、实验内容 四、实验结果 五、结论 致谢. 一、前 言. 甜草是我国南方的一种民间草药,是茜草科植物,在 《 江西草药 》《 中国草药大全 》 有其药用记载, “ 性平,味甘,有治疗黄疸型肝炎、糖尿病、外伤出血、清热解毒的功效 ” 。其叶子榨汁,可用于蜜蜂、黄蜂等蜂类的蛰伤,疗效显著。. 二、研究目的. 目前尚未见到关于甜草 Oldenlandia cantonensis How 的研究报告。甜草化学成分的研究可发现新的具有药用价值的化合物。.

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甜草化学成分研究

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Oldenlandia cantonensis How


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2004795%


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GCMS


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PE:EA=10:1 5:1 3:1 2:1 1:1 1:2 1:3GCMSABCD


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1 Oldenlandia cantonensis How

,GC-MS


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4212,Bel-7402IC506.5g/ml7.0g/ml Mcg-803IC508.0g/ml7.0g/ml


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A1H-NMRCDCl3,TMS,ppm)7.2233.6342.3402.3162.2912.2722.2461.2771.2321.1441.1230.8770.8550.8320.810

AIR/cm1KBr344829202851236623421740165215451463143813781172 A


A h nmr

AH-NMR


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B1H-NMRCD3COCD3TMSppm5.2265.2152.7932.0572.0491.2931.1711.1280.9880.9690.9520.9430.9180.8980.8840.8650.8390.8100.783

IR/cm1KBr342129271690165115741456140712731185


B h nmr

BH-NMR


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C 1H-NMRCD3COCD3TMSppm7.9815.2225.2085.1972.7942.2502.2132.0451.9571.9431.9331.9221.9021.8911.1681.1250.9820.9640.9490.9370.9140.8940.8700.8350.777

IR/cm1KBr3428292728562337173616891632157414581404138512741254117011071042997


C 1 h nmr

C1H-NMR


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DEPT

13C NMR

1H NMR

1

CH2

38.2

1.54

2

CH2

23.7

1.50, 1.91

3

CH

76.8

3.00

4

C

38.3

5

CH

54.7

0.66

6

CH2

26.9

1.46

7

CH2

32.6

1.57

8

C

46.7

9

CH

46.9

1.45

10

C

41.6

11

CH2

22.7

1.86

12

CH

124.5

5.13

13

C

138.1

14

C

41.5

15

CH2

27.5

1.80

16

CH2

17.9

1.46, 1.30

17

CH2

32.6

1.25,1.43

2 DNMR(DMSO-d6, TMS, 500MHz)


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18

CH

52.3

2.11

19

CH3

15.9

0.68

20

CH3

28.1

0.90

21

CH3

15.1

0.87

22

CH3

16.9

0.76

23

CH3

23.2

1.04

24

CH

38.3

0.94

25

C

178.1

26

CH2

30.0

1.42

27

CH

38.4

0.95

28

CH3

16.8

0.82

29

CH3

20.9

0.92

3-OH

4.15

25-COOH

11.8

C29H48O3, FABMSm/z 445[M+1]+444C, 78.33; H, 10.90; N, 0.000IRKBr3420, 2970, 2928, 2871, 1693, 1575, 1455, 1407, 1313, 1279, 1249, 1142, 1091, 1032, 996, 758, 661, 568


D 13 c nmr

D13C-NMR


D 1 h nmr

D1H-NMR


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D


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D

D

+


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IC50

g/mL

C

18

D

15

CD

3 hTOP I IC50


4 bel 7402 ic 50

IC50

g/mL

IC50

g/mL

C

C

6.5

8.0

D

D

7.0

7.0

4 Bel-7402IC50

5 Mcg-803IC50


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2 11

2


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