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CF week. Anatomy of the LRT. Airway branchings & LMB vs RMB Name levels from trachea to alveoli Changes as we descend resp tract? Pleural cavity Lungs – lobes and fissures Circulation Innervation. Respiratory epithelium. Bronchus. Bronchiole. Terminal bronchiole.

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Presentation Transcript
anatomy of the lrt
Anatomy of the LRT
  • Airway branchings & LMB vs RMB
    • Name levels from trachea to alveoli
    • Changes as we descend resp tract?
  • Pleural cavity
  • Lungs – lobes and fissures
  • Circulation
  • Innervation
physiology mechanics
Physiology - mechanics
  • Pleural pressure
  • Muscles and movements in inspiration
  • Muscles and movements in expiration
    • Passive vs active expiration
  • Forces keeping alveoli open vs closed
physiology
Physiology
  • Ventilation
    • Pulmonary ventilation vs alveolar
    • What causes dead space?
physiology1
Physiology
  • Diffusion
    • What are the layers of the blood-air-barrier?
    • What effects the rate of diffusion?
physiology2
Physiology
  • Perfusion
    • Normal V/Q ratio
    • Hypoxic pulmonary vasoconstriction
pathology of obstruction
Pathology of obstruction
  • Tubes – muscular vs non-muscular
  • Non-mechanical
  • Mechanical - extramural, intramural and intraluminal
  • Examples
  • Consequences
slide14
CF
  • Type of inheritance?
  • Incidence
sequelae
Sequelae

Lung

  • Abnormal mucous, less, thicker
  • Infection/ inflammation
  • Bronchiectasis

Pancreas

  • Pancreatic obstruction leads to…

Sweat gland

  • Decreased reabsorption of NaCl.
other abnormalities
Other abnormalities
  • Bilateral absence of ductus deferens
  • Meconium ileus
  • Liver pathology
  • Males generally infertile, woman are not.
diagnosis
Diagnosis
  • Sweat test and DNA test for CFTR mutation
  • 6 classes of mutation
management
Management

Can you list 5 management options?

management1
Management

• Chest physiotherapy

Postural drainage and manual techniques

Breathing & airway clearance +/- PEP devices

Exercise therapy

• Medications

Bronchodilators (preventers and relievers)

Anti-inflammatory therapy

Mucolytics & pulmozyme(rhDNase)

• IV antibiotics (infective exacerbations)

• Oxygen therapy (infective exacerbations, or end stage)

• Nutritional support (+/- enzymes)

• Transplantation (end stage)

• Potential gene therapy

- aim to restore CTFR function

psychosocial burden of cf
Psychosocial/burden of CF
  • Prognosis
  • Time consuming, life altering illness.
  • Costly
  • Good opportunity to learn about support and respite groups
surface anatomy
Surface anatomy

6,8 and 10 for lung. 8, 10 and 12 for pleurae.

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