BIOMEDICAL RESEARCH INSTITUTE

1. BIOMEDICAL RESEARCH INSTITUTE FOUNDATION FOR RESEARCH & TECHNOLOGY- HELLAS BRI - FORTH

2. Legal Framework • 1998- Establishment of “Ioannina Biomedical Research Institute” (IBRI) as an autonomous Institute, under the auspices of General Secretariat for Research and Technology, Ministry of Development • 2001- Merger with “Foundation for Research and Technology-Hellas” (FORTH) New legal name: “Biomedical Research Institute / Foundation for Research and Technology-Hellas” (BRI-FORTH) • 1-1-2002- Financial & Administrative merger with FORTH

3. Administration & Personnel • Director: Prof. Efthimios Kaxiras, Dep. of Materials Science & Engineering, University of Ioannina • Deputy Director: Prof. Theodore Fotsis, Lab. of Biological Chemistry, University ofIoannina • Institute Honorary Fellows:Prof.Christos Massalas,Dep. of Materials Science & Engineering, University of Ioannina • Researchers: Dr. Carol Murphy (Rank B) • Administrative Officer: Ms. Ioanna Mpempi • Accountant: Mr. Charalampos Kalogeropoulos • Accountant: Ms. Basiliki Gouda • Technician: Mr. Georgios Bellos

4. Collaborating Faculty Members • Georgatos, Spyros, Prof., Medical School, U.I. • Evaggelakis, George, Assoc. Prof, Dep. of Physics, U.I. • Zonios, George, Assist. Prof., Dep. of Materials Science & Engineering, U.I. • Ioannidis, John, Prof., Dep. of Epidemiology, U.I. • Lagaris, Isaak,Prof., Dep. of Computer Science, U.I. • Likas, Aristidis, Assist. Prof., Dep. of Computer Science, U.I. • Floudas, George,Assoc. Prof., Dep. of Physics, U.I. • Fotiadis, Dimitrios, Assoc. Prof. Dep. of Computer Science, U.I. • Christoforidis, Savvas, Lecturer, Medical School, U.I. • Papamarkaki, Thomais, Assist. Prof, Lab. of Biological Chemistry, U.I.

5. Personnel in Research Projects(Period 2001-2004) • 52Researchers with work contracts • 22 Postgraduate Students

6. Premises BRI-FORTH doesn’t have at present its own building: • Secretariat & Accounting Room: hosted by Medical School • Laboratory of Dr. C. Murphy: hosted by Laboratory of Biological Chemistry, U.I. • Laboratories of Biomedical Technology: hosted by Dep. of Computer Science, Dep. of Materials Science & Engineering, U.I. • Laboratory of Epidemiology: hosted by Medical School, U.I.

7. Equipment and funding (period 2000-2004 • Equipment purchase: 1.470.600 Euros, funded by GSRT: - Biochemistry-Molecular Biology: 970.600 Euro - Biomedical Technology: 500.000 Euro • Funded Competitive Projects: - Competitive Projects E.U: 2.172.108 Euro -Competitive Projects GSRT: 162.553Euro -Other Projects: 80.000Euro

8. Completed projects (period 2000-2004) • PLACEBO, “An Innovative Computational Platform for Solving Differential Equations in Modeling Biomedical Processes”, EU(IST) • h-Life, “Intelligent Personal Health Assistant”, EU(IST) • Active Health, “Active Environment for Health Promotion and Disease Prevention”, EU(IST) • CITATION, “Citizen Information Tool in Smart Administrations”, EU(IST) • US Bone, “A Remotely Monitored Wearable Ultrasound Device for the Monitoring and Accelerationof Bone Healing”,EU(IST) • DROMEAS-A Wearable Platform for the Monitoring of Health Condition and Sport Performance of Athletes and the Real Time Prevention of Sport Injuries, EPISEY (Subcontracting)(IST) • “Nearest-neighbour relationships of emerin, LAP2beta, and I.BR: a key to understanding the molecular basis of "envelopathies”, Association Francaise contra les Myopathies

9. Projects in progress (period 2000-2004) • “Global Genetics Consortium: Collaborative pooled analysis on the association of the alpha-synuclein gene REP1 variant and Parkinson's disease”, Michael J. Fox Foundation • “Empo Young Investigator”, EMBO • “Towards a process for ventilating air sterilization”, Joint Research and Technology Programmes 2004-2006, GSRT • “Signal transduction and membrane trafficking in endothelial cells”, GSRT, PENED 2001 • Intelligent, “Human Network for the study and dissemination of the use of intelligent transplants and artificial organs in Medicine”, GSRT,EPAN-HUMAN NETWORKS

10. Events and seminars (period 2000-2004) Events: • 6thMeeting of FORTH Researchers (1-3/3/02 Ioannina-Metsovo) • Informative Meeting (U.I, BRI-FORTH, Industrial Property Organization, Network “PRAXI”, 14-15/11/02 Ioannina) • Conference in the framework of Hellenic Presidency of E.U.:" Foresight in the Enlarged European Research & Innovation Area"(GSRT, BRI-FORTH 15-16/5/03 Ioannina) • 6h International Workshop on Mathematical Methods in Scattering Theory and Biomedical Engineering (18-21/9/03 Tsepelovo) • Symposium "Molecular epidemiology of Parkinson's disease: the Global Genetics Consortium” (Dep. of Hygiene and Epidemiology, U.I, BRI –FORTH, 22/9/2004) • Mini-symposium "Membrane trafficking"(BRI –FORTH, Lab. of Biological Chemistry, Medical School, U.I, 23 –25/4/04) Seminars: 20

11. Objectives & Prospects for 2005-2008 Premises • Renovation of a 800 s.m. buildingusing funds from Region of Epirus, 455.000 euro • A new building will be constructed in a lot provided by U.I. Laboratory equipment for research teams Expanding- renewal of laboratory equipment from: • Structural Programs • Government Operational Programs • Community Support Framework III Operational Programs

13. Objectives & Prospects for 2005-2008 Staffing according the budget 2004 (261.337euro): • Hiring of 4 new Researchers Research Directions: • Molecular mechanisms of Cell function • Computational Biology • Bioinformatics-Modeling • Epidemiology • Biophysics Applications Collaboration is necessary: Medicine, Biology, Chemistry, Physics, Science of Materials, Computer Science, Applied Mathematics

14. Endothelial-smooth muscle cell interactions

15. Stages of angiogenesis

16. Haematopoetic stem, progenitors and precursor cells co-mobilize with CEPs

17. Νεοπλασματική αγγειογένεση: Μοριακοί μηχανισμοί και εφαρμογές Ενδοθηλιακά κύτταρα Περισσότερα αγγεία: Παραπέρα αύξηση του όγκου - μετάσταση Νέα αγγεία: Αύξηση του όγκου Αγγειογενετικοί παράγοντες Αντιαγγειογενετική θεραπεία Υποστροφή του όγκου

19. Chemistry Medicine BRI-FORTH Material Science Physics Biology Computer Science