Antimicrobial Therapy. Chemotherapy: any treatment of patient with chemicals to treat a condition. Now word associated with cancer treatment Our focus is on antimicrobial agents “Antibiotics”: antibiotics, semi-synthetic, or synthetic
Selective toxicity is the ability of the drug to harm the target without harming the host. Bacteria have many targets that are biologically different from us that the drugs can hit. As the target becomes more like us, there are fewer and fewer drugs that are selectively toxic: fungi, protozoa, worms, viruses, cancer.
Bacterial enzymes (beta lactamases = penicillinases) destroy this ring. Penicillins no longer work. Some penicillins were created to resist these enzymes.
Disruption of membrane function
Amoxacillin and clavulanic acid Augmentin
Trimethoprim and sulfamethoxazole Bactrim
Neomycin, bacitracin & polymyxin Neosporin