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Do now: List at least 3 components you would find in e ach compartment. Axon. Dendrites. Cell Body. Synapse. Slower. Fast. Dendrites. Cell Body. Axon. Synapse. Why is transport to the synapse faster?. Moving components to the synapse and back.

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Dendrites

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Dendrites

Do now:

List at least 3 components you would find in

each compartment.

Axon

Dendrites

Cell Body

Synapse


Dendrites

Slower

Fast

Dendrites

Cell Body

Axon

Synapse

Why is transport to the synapse faster?


Dendrites

Moving components to the synapse and back

Use your worksheet to match the process with the number on the left:

Vesicles are filled with neurotransmitter and then the action potential makes the vesicles release their neurotransmitter into the synapse

The cell body makes hollow spheres of membrane called vesicles

Vesicles that need repairing are transported back to the cell body

Vesicles can be refilled with transmitter or repaired if they are damaged

Vesicles are transported to the synapse on microtubule tracks.

nucleus

3.

1.

1.

5.

2.

5.

4.

3.

4.

2.

synapse


Dendrites

How do we do it – and how do we do it fast enough?

Vesicles are transported to the synapse on tracks made of bundles of microtubules

nucleus

1.

Watch video on next slide.

2.

5.

Write down four things you notice

about how vesicles are transported

3.

4.

synapse


Dendrites

How do we do it – and how do we do it fast enough?


Dendrites

Write down 4 things you noticed about vesicle transport.

  • Transport can be in two directions.

  • The same vesicle can move backwards and forwards

  • Vesicles don’t move all the time.

  • When they are moving, they move at the same speed.

nucleus

1.

2.

5.

What hypotheses can you make about

how transport works?

3.

4.

synapse


Dendrites

What hypotheses can you make about how transport works?

nucleus

1.

The vesicles must be motorized to allow them to move up and down.

2.

5.

3.

4.

synapse


Dendrites

What hypotheses can you make about how the motor works?

Transport can be in two directions.

The same vesicle can move backwards and forwards.

nucleus

The motors must be able to move the vesicle backwards or forwards

1.

Each vesicle must be able to work with both backwards and forwards motors.

2.

5.

3.

4.

synapse


Dendrites

What hypotheses can you make about how the motor works?

3. Vesicles don’t move all the time.

4. When they are moving, they move at the same speed.

Vesicles must be able to disembark from the motor or microtubules.

nucleus

1.

The actual time to reach the destination will be the sum of the time spent moving and the time spent stationary.

2.

5.

The motors on different vesicles must be similar.

3.

4.

synapse


Dendrites

How would you figure out what the vesicles are

and how they move?

To ynapse

Cell body

2. Moving to cell body

1. Moving to synapse


Vesicle transport activity

Vesicle transport activity

  • Divide into groups of 5 or 6.

  • Each person in a group take a component card (blue).

  • Then, use the track cards (yellow) to determine which direction on the microtubules your component needs to go.

  • Then, select a motor cards (red) to get your component where it needs to go. Be sure that your motor selection will operate on your track selection.

  • Finally, use the experiment cards (green) to devise an experiment to check if you are right.

  • You can use as many experiment cards as you want.


Wrap up

Wrap up

  • Everyone who has worked on a particular component form one group.

  • Compare your transport solutions – are they the same? Which is the best? Why? Come up with a consensus solution to present.

  • Compare your experimental strategies – are they the same? Which is best? Why? Come up with a consensus solution to present.


Wrap up1

Wrap up

  • Where your strategies specific enough? How did you make sure that a component destined for the axon wouldn’t end up at the synapse for example.


Homework

Homework

  • Complete the worksheet, answering the following questions:

    • Research kinesins. If you want to transport a single synaptic vesicle from neuronal cell body at the base of your spine to your big toe, how much ATP will you use?

    • What does this tell you about axonal transport to the synapse?


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