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“Flexible electrical recording from cells using nanowire transistor arrays”. Onur Ergen. Electirical Engineering and computer science University of California, Berkeley [email protected] EE235 Student Presentation 2 4 may 2009. Outline.

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Onur ergen

“Flexible electrical recording from cells using nanowire transistor arrays”

Onur Ergen

Electirical Engineering and computer science

University of California, Berkeley

[email protected]

EE235

Student Presentation 2

4 may 2009


Outline

Outline

  • Advantage of using NWsfor establishing active interfaces with biological systems.

  • Fabrication and transfer method of NWs.

  • Discussion on experimental approach and electrical results of cardiomyocyte signals.

  • Conclusion


Fabrication and transfer method of nws

Fabrication and transfer method of NWs

Synthesis of semiconductor silicon nanowires.

Scheme of nanowire synthesis set-up.

Transfer of Nws with using contact printing.

  • Javey A, Nam S, Friedman RS, Yan H, Lieber CM (2007) Layer-by-layer assembly of nanowires for three-dimensional, multifunctional electronics. NanoLett 7:773–777.

  • PatolskyF, Zheng G, Lieber CM (2006) Fabricaton of silicon nanowire devices for ultrasensitive, label-free, real-time detection of biological and chemical species. Nat Protocols 1:1711–1724. A P


Schematic of experimental approach

Schematic of Experimental Approach

  • NWFET arrays coupled to embryonic chicken cardiomyocytes.

    • A-) NWFET chip, where NW devices are located at central region of chip. Source and 2 drain electrodes connected to a vertically oriented NW.

    • B-)Cardiomyocytes cultured on thin rectangular pieces of PDMS.

    • C-) PDMS piece with cultured cells oriented over the device region of NWFET chip.

    • D-)Schematic view of a cardiomyocyte oriented over a NW FET device.

Embryonic chicken cardiomyocytes.


Measurement of c ardiomyocyte signals

Measurement of Cardiomyocyte Signals

--Measurement of cardiomyocytesignals--

--Effect of applied force on recorded signals--

Back into contact

retracted


Previous approach electrical recording from hearts with flexible nanowire device arrays

Previous Approach ; Electrical Recording from Hearts with Flexible NanowireDevice Arrays

B.P. Timko, T. Cohen-Karni, G. Yu, Q. Qing, B. Tian and C.M. Lieber, "Electrical Recording from Hearts with Flexible Nanowire Device Arrays," NanoLett. 9, 914-918 (2009).


Measurement of cardiomyocyte signals

Measurement of Cardiomyocyte Signals

--Recording from Distinct Regions--

--Multiplexed Recording--


Conclusions

Conclusions

  • Good flexible approach to interface silicon NWFETs with cells in which optically transparent PDMS/cell substrates are manipulated to place specific cells over particular NWFET elements.

  • Amplitude variations signals of cardiomyocytes from 31 to 7 nSfor different Vg values recorded (while keeping from calibrated voltage remained constant ).

  • Multiplexed recording of signals shows cardiomyocytemonolayers enabled temporal shifts and signal propagation.

  • Approach increases the flexibility and opens up opportunities for interfacing cardiomyocytes and other cells to high-performance NWFETs,


Supplementary

Supplementary

  • Javey A, Nam S, Friedman RS, Yan H, Lieber CM (2007) Layer-by-layer assembly of nanowires for three-dimensional, multifunctional electronics. NanoLett 7:773–777.


Transport measurement of sinw devices in air

Transport measurement of SiNW devices in air

Nws transfer on Si substrate by drop-cast

  • PatolskyF, Zheng G, Lieber CM (2006) Fabricaton of silicon nanowire devices for ultrasensitive, label-free, real-time detection of biological and chemical species. Nat Protocols 1:1711–1724. A P


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