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Craniofacial anomalies

Craniofacial anomalies. HuGENet NETWORK OF NETWORKS WORKSHOP October 2005. Julian Little Canada Research Chair in Human Genome Epidemiology Department of Epidemiology & Community Medicine University of Ottawa. Origins. WHO Human Genetics Programme, 2000 Financial support from NIDCR (US)

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Craniofacial anomalies

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  1. Craniofacial anomalies HuGENet NETWORK OF NETWORKS WORKSHOP October 2005 Julian Little Canada Research Chair in Human Genome Epidemiology Department of Epidemiology & Community Medicine University of Ottawa

  2. Origins • WHO Human Genetics Programme, 2000 • Financial support from NIDCR (US) • Five-year project designed to take forward international strategy on craniofacial anomalies

  3. Objectives of WHO project • to develop an international network for consensus building, planning and development for international collaborative biomedical, epidemiological and behavioural studies in the core areas of craniofacial anomalies research • to create a directory of research resources in craniofacial anomalies. • to create the International Database on Craniofacial Anomalies (CFA)

  4. Core areas • genetic basis of CFA • gene-environment interactions involved in CFA • prevention of CFA • optimal treatment of CFA

  5. Consensus meetings • Nov 2000 – concurrent workshops on (1) genetic basis (2) g-e interaction (3) treatment • May 2001 – prevention • Dec 2001 – global registry

  6. 2002 2003

  7. Consensus meetings • Nov 2000 – concurrent workshops on (1) genetic basis (2) g-e interaction (3) treatment • May 2001 – prevention • Dec 2001 – global registry • Dec 2004 – progress and future strategies ________

  8. Reported investigations on gene-environment interaction in aetiology of oral clefts

  9. Gene-environment interaction and oral clefts: data and sample collections

  10. Identifying teams • List developed from WHO reports and literature searches • Asked those who attended WHO meetings (1) about concept (2) to review list and extend if possible • Contact additional teams identified

  11. Teams • with established data and sample collections • with ongoing data and sample collections • planning to establish data and sample collections

  12. Numbers of teams

  13. N of cases from cc studies; trios; samples; (studies)………

  14. Co-ordination • Ottawa • Dundee (Peter Mossey) • Iowa (Jeff Murray)

  15. Funding

  16. Other issues • Different designs • Samples • Governance • Further analyses possible? • Outside country? • Elsewhere within country? • Only in own centre?

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