Coupling of MR visible GABA, glutamate and glutamine to metabolic and neuronal pathways. Navid Seraji-Bozorgzad. Selective Serotonin Reuptake Inhibitors (SSRI) are widely used in treatment of depression, and other psychiatric disorders.
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In the beginning (circa 2004)…
There was serotonin.
HR-MAS 1H-MRS Neurochemical profile of rats 1 hr after treatment with Citalopram. (n=8)
What role, if any, does MRS play in understanding the neurobiology of psychopharmacological agents (besides phenomenology)?
Is there a neuronal component to the MRS findings?
Gabaculine increased GABA levels 2-3 folds in all brain regions. The increase, however, was region dependant (highest in cortical v. subcortical regions)
Gabaculine also decreased glutamine levels in HC and AST. Correlations analysis confirmed an inverse GLN – GABA relation.
Special thanks to Dr. Haacke and the people of Harper MR Center.