Evidence that talin alternative splice variants from
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Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion. Sotheavy Vann Ngoc Phan. What are Talins?. Modular cytoskeletal proteins-cell adhesions Talin 1 and 2 have non-redundant roles Talin 1-focal cell adhesion and cellular motility

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Evidence that talin alternative splice variants from Ciona intestinalis have different roles in cell adhesion

Sotheavy Vann

Ngoc Phan


What are talins
What are Talins?

  • Modular cytoskeletal proteins-cell adhesions

  • Talin 1 and 2 have non-redundant roles

    • Talin 1-focal cell adhesion and cellular motility

    • Talin 2-lables F-actin stress fibers for stable adhesion assemblies

    • C. Intestinalis-talin a and talin b

  • Why study talins?


Ciona intestinalis
Ciona Intestinalis

http://www.google.com/url?source=imglanding&ct=img&q=http://cfb.unh.edu/phycokey/Choices/Anomalous_Items/Chordates/tunicates/tunicate_03_600x450_larvae_riley_nolan.jpg&sa=X&ei=XLiFT9ePDYie8gT15cXCCA&ved=0CA0Q8wc4FQ&usg=AFQjCNGQ0Y-9A4X0sBmrUGdJaCGDTbektg

Phylum Chordata

Life Cycle

Good Model Organism

http://upload.wikimedia.org/wikipedia/commons/thumb/f/fe/Cionaintestinalis.jpg/220px-Cionaintestinalis.jpg


Expressed sequence tag
Expressed Sequence Tag

  • Gene Discovery Tool

  • EST Method

    • Involves the Central Dogma of genetics

  • Other Methods

    • Searching for signal sequences

    • Comparing genomes








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