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Lecture 20 – Epigenomics – Animals

Lecture 20 – Epigenomics – Animals. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. Epigenetic Regulation by piwi -associated DNA methylation in Mammalian Germline. Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510.

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Lecture 20 – Epigenomics – Animals

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  1. Lecture20– Epigenomics – Animals BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Epigenetic Regulation by piwi-associated DNA methylation in Mammalian Germline Bucher et al., (2012) Current Opinion in Plant Biology 15 (5): 503-510

  3. Animal piwi-RNA and DNA methylation In mammals, DNA methylation and demethylation are involved in diverse processes including: early embryogenesis stem cell differentiation genomic imprinting 75, 221, Mayer W, Niveleau A, Walter J, Fundele R, Haaf T. Demethylation of the zygotic paternal genome. Nature 2000; 403:501–502. Haaf T. Methylation dynamics in the early mammalian embryo: implications of genome reprogramming defects for development. Curr Top MicrobiolImmunol 2006; 310:13–22. Watanabe D, Suetake I, Tada T, Tajima S. Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mech Dev 2002; 118:187–190. Latham T, Gilbert N, Ramsahoye B. DNA methylation in mouse embryonic stem cells and development. Cell Tissue Res 2008; 331:31–55. ReikW, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2001; 2:21–32. IderaabdullahFY, Vigneau S, Bartolomei MS. Genomic imprinting mechanisms in mammals. Mutat Res 2008; 647:77–85.

  4. Animal piwi-RNA and DNA methylation (cont) X chromosome inactivation silencing of repetitive elements 224. DNA methylation is also involved in regulating neuronal development and development of cancers 225, 226. Heard E, Disteche CM. Dosage compensation in mammals: fine-tuning the expression of the X chromosome. Genes Dev 2006; 20:1848–1867.Senner CE, Brockdorff N. Xist gene regulation at the onset of X inactivation. CurrOpin Genet Dev 2009; 19:122–126. Chen RZ, Pettersson U, Beard C, Jackson-Grusby L, Jaenisch R, DNA hypomethylation leads to elevated mutation rates. Nature 1998; 395:89–93.  Dulac C. Brain function and chromatin plasticity. Nature 2010; 465:728–735. Feinberg AP, Ohlsson R, Henikoff S, The epigenetic progenitor origin of human cancer. Nat Rev Genet 2006; 7:21–33. J.R., and Pikaard, C.S. 2011. Nature Reviews Molecular Cell Biology 12:483–492.

  5. Figure 1 The clonal genetic model of cancer. Feinberg AP et al. (2005) The epigenetic progenitor origin of human cancer Nat Rev gene.7: 21–33 doi:10.1038/nri1748

  6. Figure 2 The epigenetic progenitor model of cancer. Feinberg AP et al. (2005) The epigenetic progenitor origin of human cancer Nat Rev gene.7: 21–33 doi:10.1038/nri1748

  7. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  8. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  9. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

  10. Genomic and epigenomicregualtion of adipose tissue inflammation in obesity Toubal et al. Trends in Endocrinology & Metabolism, 2013

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