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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on April 21, 2011. Targeted Drug Delivery to the Brain & Central Nervous System. Magnetic-Guidance of Nanoparticles. Description of Experiments.

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Prepared for the L aboratory for P roduct and P rocess D esign Created by Eric Lueshen

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  1. Prepared for the Laboratory for Product and Process Design Created by Eric Lueshen Advisor: Andreas A. Linninger Presented on April 21, 2011 Targeted Drug Delivery to the Brain & Central Nervous System

  2. Magnetic-Guidance of Nanoparticles

  3. Description of Experiments

  4. 10nm Fe3O4 MNP Experiments (1/3 inch) • Diffusion only (i.e. no magnet) • Diffusion + Magnetic guidance

  5. 10nm Fe3O4 MNP Experiments (1/6 inch) • Diffusion only (i.e. no magnet) • Diffusion + Magnetic guidance

  6. Advanced Photon Source Storage Ring

  7. XFM with the 8-BM beamline • Prostate cancer in mice • Glucose-coated 8nm Fe3O4@TiO2 nanoparticles • Study the cellular uptake • Capable of imaging gels in 3-D

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