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# of animals

F12 Gy PI. F21Gy PI. F15 Gy PI. F24Gy PI. F18Gy PI. F27Gy PI. A. B. Fractionated irradiation. Single dose irradiation. # of animals. # of animals. Days post T cell transfer. Days post T cell transfer. 12Gy PI. 9 Gy PI. 10.5 Gy PI. 15Gy PI. Supplementary Figure

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# of animals

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  1. F12 Gy PI F21Gy PI F15 Gy PI F24Gy PI F18Gy PI F27Gy PI A B Fractionated irradiation Single dose irradiation # of animals # of animals Days post T cell transfer Days post T cell transfer 12Gy PI 9 Gy PI 10.5 Gy PI 15Gy PI Supplementary Figure (A, B) Acute toxicity of increasing irradiation. One million effector pmel-1 CD8+ T cells (P) were transferred with rhIL-2 (I) in tumor-bearing C57BL/6 mice which were either irradiated with a single dose of irradiation directly at the day of T cell transfer (A) or a dose fractionated over 6 times twice daily up to the amount indicated in the legend (B). All mice received an HSC transplant and were euthanized if they exhibited poor grooming, appeared to be in distress, or showed evidence of weight loss. Data are representative of two independent experiments.

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