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Biology B2

Biology B2. Lesson 3: DNA. Connect. On each post-it, write one fact that you think you already know about DNA . Stick this on your desk. Collect an exam question. Connect. DO NOT ANSWER the exam question. Instead, write your own ‘Walking Talking’ Notes onto it. What Are We Learning?.

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Biology B2

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  1. Biology B2 Lesson 3: DNA

  2. Connect • On each post-it, write one fact that you think you already know about DNA. • Stick this on your desk. • Collect an exam question.

  3. Connect • DO NOT ANSWER the exam question. • Instead, write your own ‘Walking Talking’ Notes onto it.

  4. What Are We Learning? • By the end of this lesson, you should: • Be able to describe the structure of DNA. • Be able to explain how DNA codes for amino acids. • Consider the importance of the discovery of DNA.

  5. SMSC & RWCM • Cultural: Consider the reasons why some discoveries are more important than others. • Social: Respect the views of others. • Reading: Identify key facts. • Writing: Use key words in the correct context.

  6. Today’s Learning Progress Step 1: Be able to describe the simple structure of DNA and use some key words. Progress Step 2: State the key parts of a DNA molecule. Progress Step 3: Describe the structure and function of DNA Increasing Difficulty

  7. Starting Points • DNA stands for DeoxyriboseNucleic Acid. • Think: • What is the structure of DNA? • Why is DNA so important?

  8. DNA: The Basics • Deoxyribose Nucleic Acid can be descibed as having a coiled double helix shape. • It is unique because it is able to replicate.

  9. DNA: The Basics • Each strand of DNA is made up of a combination of four bases. • The order in which each of these pairs appears is important.

  10. DNA: The Basics • In DNA, there are four bases. These are: • Adenine • Guanine • Cytosine • Thymine

  11. DNA: The Basics • The four bases on one strand line up against the other strand always in the following pairs: • Adenine - Thymine • Guanine - Cytosine

  12. DNA: The Basics • The four base pairs are joined by Hydrogen bonds, which can be easily ‘unzipped’. • What do you know about hydrogen bonds?

  13. DNA: The Basics • Each triplet of bases on one strand of DNA codes for an amino acid. • How many combinations of bases can you come up with in four minutes?

  14. DNA: Task • How many amino acids are there in this section of DNA? Use colours to identify them. • -C-G-C-A-A-T-C-G-T-A-T-A-G-C-G-A-A-C- • What would be the opposite strand of this DNA?

  15. DNA: Task • How many amino acids are there in this section of DNA? Use colours to identify them. • -C-G-C-A-A-T-C-G-T-A-T-A-G-C-G-A-A-C- • What would be the opposite strand of this DNA? • -G-C-G-T-T-A-G-C-A-T-A-T-C-G-C-T-T-G

  16. DNA: The Basic Structure Sugar Hydrogen Bonds Phosphate

  17. Discovering DNA • DNA was first modelled in 1953 by James Watson & Francis Crick. • There is an argument that this was the most important scientific discovery of the the 20th Century. • The Nobel Prize in Physiology or Medicine was awarded in 1962 to Watson, Crick and Maurice Wilkins.

  18. Discovering DNA: Task • Use the information in the text to produce a timeline for the discovery of DNA. • Start with the earliest events. • When you are happy, decide which events were the most significant.

  19. Rosalind Franklin Franklin’s “Photograph 51” Watson & Crick’s ball and stick model

  20. Questions • Which discovery contributed the most to the work of Watson & Crick? • Why was Erwin Chargoff’s work an important contribution to the deduction of the structure of DNA? • Why was the structure of DNA seen as such an important scientific development?

  21. Franklin: A Victim Of Sexism? • Franklin is best known for her work on the X-ray diffraction images of DNA which led to the discovery of DNA double helix. • Her data, according to Francis Crick (Nobel Prize Winner), were "the data we actually used” to formulate Crick and Watson's 1953 hypothesis regarding the structure of DNA. • What do you think about this?

  22. What Are We Learning? • By the end of this lesson, you should: • Be able to describe the structure of DNA. • Be able to explain how DNA codes for amino acids. • Consider the importance of the discovery of DNA.

  23. Reflection • Look at your Post It Note from the beginning of the lesson. • Review what you wrote and comment upon the accuracy of your original comment. • Share one learning point with a neighbour.

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