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HEART-LUNG TRANSPLANTATION

HEART-LUNG TRANSPLANTATION. Overall. ISHLT. 2007. J Heart Lung Transplant 2007;26. NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR. ISHLT.

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HEART-LUNG TRANSPLANTATION

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  1. HEART-LUNG TRANSPLANTATION Overall ISHLT 2007 J Heart Lung Transplant 2007;26

  2. NUMBER OF HEART-LUNG TRANSPLANTS REPORTED BY YEAR ISHLT NOTE: This figure includes only the heart-lung transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of heart-lung transplants worldwide has declined in recent years. 2007 J Heart Lung Transplant 2007;26

  3. AVERAGE CENTER VOLUMEHeart-LungTransplants: January 1, 1998 - June 30, 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  4. DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY CENTER VOLUMEHeart-Lung Transplants: January 1, 1998 - June 30, 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  5. DISTRIBUTION OF HEART-LUNG TRANSPLANTS BY LUNG CENTER VOLUMELung Transplants: January 1, 1998 - June 30, 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  6. HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival (Transplants: January 1982 - June 2005) Half-life = 3.1 years Conditional Half-life = 8.8 years N=3,184 Survival (%) N at risk at 20 years = 7 ISHLT 2007 J Heart Lung Transplant 2007;26

  7. HEART-LUNG TRANSPLANTATION Adult Recipients ISHLT 2007 J Heart Lung Transplant 2007;26

  8. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS (January 1982 - June 2006) “Other” includes cancer, LAM, OB, sarcoidosis, bronchiectasis ISHLT 2007 J Heart Lung Transplant 2007;26

  9. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS(Transplants: January 1982 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  10. DIAGNOSIS IN ADULT HEART-LUNG TRANSPLANTS BY ERA “Other” includes OB (non-ReTX), Bronchiectasis, Sarcoidosis ISHLT 2007 J Heart Lung Transplant 2007;26

  11. ADULT HEART-LUNG TRANSPLANTATIONIndications By Year (%) ISHLT 2007 J Heart Lung Transplant 2007;26

  12. ADULT HEART-LUNG TRANSPLANTATIONIndications By Year (Number) ISHLT 2007 J Heart Lung Transplant 2007;26

  13. ADULT HEART-LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  14. ADULT HEART-LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  15. ADULT HEART-LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  16. HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival for Adult Recipients(Transplants: January 1982 - June 2005) Half-life = 3.4 Years Conditional Half-life = 9.0 Years N=2,571 Survival (%) ISHLT 2007 J Heart Lung Transplant 2007;26

  17. HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival for Adult Recipients by Era(Transplants: January 1982 - June 2005) Half-life (Years): 1982-1995 = 3.0; 1996-1999 = 3.4; 2000-6/2005 = 5.2 Conditional Half-life (Years): 1982-1995 = 8.9; 1996-1999 = 9.5; 2000-6/2005 = n/a Survival (%) P-value comparing all: 0.0082 ISHLT 2007 J Heart Lung Transplant 2007;26

  18. ADULT HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  19. ADULT HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis Conditional on Survival to 1 Year(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  20. ADULT HEART-LUNG RECIPIENTS Functional Status of Surviving Recipients (Follow-ups: April 1994 – June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  21. ADULT HEART-LUNG RECIPIENTSEmployment Status of Surviving Recipients(Follow-ups: April 1994 – June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  22. ADULT HEART-LUNG RECIPIENTS: Rehospitalization Post-transplantof Surviving Recipients(Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  23. ADULT HEART-LUNG RECIPIENTS Induction ImmunosuppressionFor transplants between January 2001 through June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  24. ADULT HEART-LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2000 - December 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  25. ADULT HEART-LUNG RECIPIENTSInduction Immunosuppression (Transplants: January 2000 - December 2005) Any Induction Polyclonal ALG/ATG OKT3 IL2R-antagonist ISHLT 2007 J Heart Lung Transplant 2007;26

  26. ADULT HEART-LUNG RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between January 2001 through June 2006 NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2007 J Heart Lung Transplant 2007;26

  27. ADULT HEART-LUNG RECIPIENTSMaintenance Immunosuppression Drug Combinations at Time of Follow-upFor follow-ups between January 2001 through June 2006 NOTE: Different patients are analyzed in Year 1 and Year 5 ISHLT 2007 J Heart Lung Transplant 2007;26

  28. POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTSCumulative Prevalence in Survivors within 1 Year Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  29. POST-HEART-LUNG TRANSPLANT MORBIDITY FOR ADULTSCumulative Prevalence in Survivors within 5 Years Post-Transplant (Follow-ups: April 1994 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  30. Freedom from Coronary Artery Vasculopathy For Adult Heart-Lung Recipients(Follow-ups: April 1994-June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  31. Freedom from Bronchiolitis Obliterans For Adult Heart-Lung Recipients(Follow-ups: April 1994-June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  32. Freedom from Severe Renal Dysfunction*For Adult Heart-Lung Recipients(Follow-ups: April 1994-June 2006) *Severe renal dysfunction = Creatinine > 2.5 mg/dl (221 μmol/L), dialysis or renal transplant ISHLT 2007 J Heart Lung Transplant 2007;26

  33. MALIGNANCY POST-HEART-LUNG TRANSPLANT FOR ADULTSCumulative Prevalence in Survivors(Follow-ups: April 1994-June 2006) * Recipients may have experienced more than one type of malignancy so sum of individual malignancy types may be greater than total number with malignancy. ISHLT 2007 J Heart Lung Transplant 2007;26

  34. Freedom from MalignancyFor Adult Heart-Lung Recipients(Follow-ups: April 1994- June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  35. ADULT HEART-LUNG TRANSPLANT RECIPIENTS: Cause of Death(Deaths: January 1992 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  36. HEART-LUNG TRANSPLANTATION Pediatric Recipients ISHLT 2007 J Heart Lung Transplant 2007;26

  37. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNGRECIPIENTS (Transplants: January 1982 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  38. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART-LUNG RECIPIENTS(Transplants: January 1982 - June 2006) ISHLT 2007 J Heart Lung Transplant 2007;26

  39. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTSBy Year of Transplant Number of Transplants NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of pediatric heart-lung transplants worldwide has declined in recent years. ISHLT 2007 J Heart Lung Transplant 2007;26

  40. AGE DISTRIBUTION OF PEDIATRIC HEART-LUNG RECIPIENTSBy Era of Transplant Percentage of Transplants ISHLT 2007 J Heart Lung Transplant 2007;26

  41. NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTS NEED TO UPDATE ISHLT 2007 J Heart Lung Transplant 2007;26

  42. NUMBER OF CENTERS REPORTING PEDIATRIC HEART-LUNG TRANSPLANTSStratified by center volume ISHLT 2007 J Heart Lung Transplant 2007;26

  43. “Other” includes Bronchiectasis, Alpha-1, and OB (non-ReTX) DIAGNOSIS IN PEDIATRIC HEART –LUNG TRANSPLANT RECIPIENTS (Age: 11-17 Years) ISHLT 2007 J Heart Lung Transplant 2007;26

  44. PEDIATRIC HEART-LUNG TRANSPLANTS:AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  45. PEDIATRIC HEART-LUNG TRANSPLANTS:DIAGNOSIS DISTRIBUTION BY LOCATION Transplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  46. PEDIATRIC HEART-LUNG TRANSPLANTS:DONOR AGE DISTRIBUTION BY LOCATIONTransplants between January 2000 and June 2006 ISHLT 2007 J Heart Lung Transplant 2007;26

  47. PEDIATRIC HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival By Diagnosis(Transplants: January 1990 – June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  48. PEDIATRIC HEART-LUNG TRANSPLANTATIONKaplan-Meier Survival(Transplants: January 1982 - June 2005) ISHLT 2007 J Heart Lung Transplant 2007;26

  49. PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1982 - June 2005) Survival (%) ISHLT 2007 J Heart Lung Transplant 2007;26

  50. PEDIATRIC HEART-LUNG TRANSPLANTATION Kaplan-Meier Survival by Era (Transplants: January 1982 - June 2005)Conditional on Survival to 1 Year Survival (%) ISHLT 2007 J Heart Lung Transplant 2007;26

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