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第 9 章 6 节妊娠期肝内胆汁淤积症

第 9 章 6 节妊娠期肝内胆汁淤积症. Intrahepatic cholestasis of pregnancy ICP. 特点:瘙痒、黄疸、胆酸和肝酶升高 病因:不清、雌孕激素代谢、遗传、环境因素 对母亲的影响:产后出血、糖脂代谢紊乱 对围产儿的影响:早产、 FGR 、胎儿窘迫和死亡、新生儿颅内出血、神经系统后遗症. ICP 的诊断. 病史 临床表现:瘙痒 体征:搔抓痕、黄疸、尿色深、肝肿大、胎儿窘迫 辅助检查:血胆酸测定、肝功能异常、 病理检查:胎盘、肝脏活检 鉴别诊断:妊娠期急性脂肪肝、子痫前期、病毒性肝炎. ICP 的处理.

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第 9 章 6 节妊娠期肝内胆汁淤积症

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  1. 第9章 6节妊娠期肝内胆汁淤积症

  2. Intrahepatic cholestasis of pregnancy ICP • 特点:瘙痒、黄疸、胆酸和肝酶升高 • 病因:不清、雌孕激素代谢、遗传、环境因素 • 对母亲的影响:产后出血、糖脂代谢紊乱 • 对围产儿的影响:早产、FGR、胎儿窘迫和死亡、新生儿颅内出血、神经系统后遗症

  3. ICP的诊断 • 病史 • 临床表现:瘙痒 • 体征:搔抓痕、黄疸、尿色深、肝肿大、胎儿窘迫 • 辅助检查:血胆酸测定、肝功能异常、 • 病理检查:胎盘、肝脏活检 • 鉴别诊断:妊娠期急性脂肪肝、子痫前期、病毒性肝炎

  4. ICP的处理 • 保肝利胆,缓解症状:休息、葡萄糖、维生素、吸氧 • 利胆止痒:考来烯胺、苯巴比妥、熊去氧胆酸、地塞米松 • 加强孕期监护 • 适时终止妊娠 • 预防产后出血 • 不用口服避孕药

  5. 谢谢

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