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AsepticSure – Semper Paratus

AsepticSure – Semper Paratus. DEVELOPMENT TEAM. Today in America a person dies every 5 minutes from largely preventable hospital acquired infections (HAIs). This silent epidemic kills an estimated 100,000 Americans every year. (CDC)

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AsepticSure – Semper Paratus

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  1. AsepticSure – SemperParatus

  2. DEVELOPMENT TEAM

  3. Today in America a person dies every 5 minutes from largely preventable hospital acquired infections (HAIs). This silent epidemic kills an estimated 100,000 Americans every year. (CDC) The problem is not new. It has been developing for two decades, but has now reached pandemic proportions and is the 4th leading cause of death in the US. PROBLEM DEFINITION

  4. PROBLEM DEFINITION "Every year, more than ninety thousand Americans die from similar infections that have become resistant to antibiotics. That stunning figure is higher than the death toll from AIDS, car accidents and prostate cancer combined." Dan Rather Reports, The Huffington Post, Jan. 12, 2011.

  5. According to the CDC, approximately 99,000 Americans develop invasive MRSA infections every year, and about 19,000 of them die - the death rate is approximately 20% A more virulent strain of community-acquired MRSA appears to have a 50% mortality rate. Schools, playgrounds, gyms and other public facilities are now at risk. With bacteria becoming increasingly resistant to antibiotics, treatment is no longer an effective option. PROBLEM DEFINITION

  6. Magnitude of Human Suffering The American Academy of Orthopaedic Surgeons identifies MRSA as the single biggest concern for surgical procedures and suggests that it is a silent epidemic. (2007) The major causative agents (bacteria) for hospital-based infections are: Clostridium difficile (C difficile); Escherichia coli (E coli); Pseudomonas aeruginousa; Methicillin-resistant Staphylococcus aureus (MRSA); and, Vancomycin-resistant Enterococcus (VRE). PROBLEM DEFINITION

  7. Magnitude of Human Suffering Estimated number of Hospital Acquired Infections (HAIs) by site of infection: PROBLEM DEFINITION - CDC (2009)

  8. Financial Burden CDC (2009) estimates the financial burden of hospital acquired infections (HAIs) to be from $28.4 Billion (low) to $45.0 Billion (high) per year. The average attributable patient cost is $25,072 (in 2005 dollars) Range of estimated direct medical costs: PROBLEM DEFINITION - CDC (2009)

  9. PROBLEM DEFINITION Emerging Threats....... “Our nation must have the nimble, flexible capacity to produce MCMs rapidly in the face of any attack or threat, known or unknown, including a novel , previously unrecognized, naturally occurring emerging infectious disease.” – The Public Health Emergency Medical Countermeasures Review, HHS, August 2010 To achieve this goal, the approach must be highly efficacious (>6 logs), rapidly deployable, inexpensive and environmentally friendly.

  10. EXISTING APPROACHES Infection Control Strategies for Habitable Hospital Spaces

  11. PRODUCT OVERVIEW The AsepticSure Advantage • Combination of anti-oxidant gases (O3 and H202) produces very unique free radicals known as Trioxidanes, with higher anti-oxidant potential than Ozone or Peroxide alone. • By definition, hospital spaces and other public facilities can effectively and reliably be sterilized, (greater than a 6 log reduction) with a turn around time of 90 minutes • The reduced concentration of gases used renders AsepticSureharmless to the environment, electronic equipment, paint and treatment surfaces

  12. PRODUCT OVERVIEW The AsepticSure Advantage • AsepticSuretechnology is effective (6+ logs) at 80PPM O3, 1% H202, 80% RH, 20-24 degrees C, for 30 minute exposure against: all bacteria contaminating hospitals, all bacteria contaminating sports equipment, all viruses (enveloped, and non-enveloped), all fungi and fungal spores. • AsepticSure is also 100% effective against all insects, eggs and larvae including Cimexlectularius (bed bugs). • AsepticSure is ideal for Bioterrorism countermeasures.

  13. Implications for Bioterrorism Countermeasures Evidence to date indicates that the efficacy of AsepticSure as a decontamination process is not limited by unique characteristics of pathogens (Aerobic vs. Anaerobic, Spore former vs. Non-Spore formers), nor is it limited by the nature of the contaminated surface or the presence of a biofilm. The data for Bacillus subtilus and Bacillus atrophaeus is compelling. Indications are that this technology will prove equally effective against all “A” List pathogens.

  14. AsepticSure™ Model – Profile View

  15. Potential Applications COMMERCIAL DEVELOPMENT Public Health & Public infrastructure Medical Facilities & Equipment • Food Preparation Facilities • Agriculture & Kennel Facilities • Sports Facilities • Sports Equipment & Uniforms • Hotel/Motel Units • Mobile & Field Hospitals/Response Units • Contaminated Areas & Public Infrastructure (Building Remediation) • Medical Countermeasures Hospital Sterilization • Long-term and Intermediate Care Facilities • Chronic Care Facilities • Routine Medical Monitoring Equipment

  16. The Growing Threat of Bioterrorism “Biological weapons and their use or proliferation by states or non-state actors presents a significant challenge to our national security...it is quite possible that we would not obtain specific warning of an imminent threat or impending attack in time to stop it.”  - National Strategy for Countering Biological Threats, November 2009 “Exposure to anthrax spores can be deadly......AL Qaida is known to have experimented with toxic chemicals in the past and the US has made protecting against bioterrorism a priority” “Pakistan Says Anthrax sent to Premier’s Office” Associated Press Feb 1/12 .

  17. In the last two decades bioterrorism has emerged as a serious threat with serious deficiencies in response capacity and capability now being recognized. The implications to National security are indeed significant. As a cornerstone to its countermeasures strategy a rapidly deployable system with proven effectiveness against a broad range of pathogens across a broad range of environmental conditions is desperately needed to fill this recognized gap.

  18. The Growing Threat of Bioterrorism • If lives are to be saved and the population protected,the impact of an attack must be quickly contained, public infrastructure maintained and immediate response personnel protected. • Any reduction in health care infrastructure threatens what little surge capacity may be available.

  19. The Growing Threat of Bioterrorism • Limiting the spread of an agent reduces the risk of exposure which reduces the number of casualties and therefore, saves lives. • Rapid effective remediation of infrastructure maintains surge capacity which saves lives. • Rapid decontamination of vehicles, emergency shelters, diagnostics, communication equipment, medical supplies, food, and water saves lives.

  20. The ASEPTICSURE mobile decontamination system offers an effective, inexpensive solution that fills critical gaps in MCMs for biological threats in a way not previously possible.

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