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Muscle Physiology. Summer Prematriculation Program Summer 2004 Rahul Dave’. [email protected] (312) 996-7610 Rm 206 CMW. Muscles act in many organ systems. Muscles need a signal to contract. Muscle Anatomy. Motor Unit. Main Nerve. Nerve branch. Muscle. Skeletal Muscle. Smooth Muscle.

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muscle physiology

Muscle Physiology

Summer Prematriculation Program

Summer 2004

Rahul Dave’

[email protected]

(312) 996-7610

Rm 206 CMW

motor unit
MotorUnit

Main Nerve

Nerve branch

Muscle

cardiac muscle 2
Cardiac Muscle 2

Intercalated Disc

sarcomere structure
Sarcomere Structure

M-line

Z-disc

H-zone

I-band

I-band

A-band

other muscle proteins
Other Muscle Proteins

Brown Tropomyosin

Yellow Troponins

Blue Actin

Black Myosin Head Bind Site

Pink Myosin

muscle structure
Muscle Structure
  • Describe the hierarchy of organization in muscle
  • Distinguish smooth, skeletal and cardiac muscle based on histology
  • Understand and rationalize the differences between fiber types
  • Know the skeletal muscle sarcomere structure cold.
e c coupling smooth
E-C Coupling (Smooth)

Neurotransmitter

G

IP3 PIP2

Ca2+

SR

muscle contraction
Muscle Contraction
  • Know each step in transmission across the neuromuscular junction
  • Know each step in E-C Coupling for striated muscle
  • Know each step in the cross-bridge cycle for striated muscle
  • Know the differences between smooth and striated (skeletal + cardiac) muscle
preload and afterload
Preload and Afterload

Preload

The force (load) a muscle exerts prior to contraction.

Pre-contraction

Afterload

Force muscle exerts during contraction.

After [the start of] contraction

Demonstration

exercise physiology
Exercise Physiology

These are all adaptations

  • Learning new motor patterns
  • Strength exercises: muscle hypertrophy
  • Endurance exercises: changes in muscle metabolism
muscle diseases
Muscle Diseases

Metabolism

  • Lactic Acidosis
  • Glycogen Storage Diseases

Muscle Function

  • Dilated Cardiomyopathy
  • Muscular Dystrophy
  • Malignant Hyperthermia
  • Neurologic
  • Hirschsprung’s disease
  • Myesthenia Gravis
  • Multiple Sclerosis
  • Parkinson’s Disease
  • Polio
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