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Muscle Physiology. Summer Prematriculation Program Summer 2004 Rahul Dave’. [email protected] (312) 996-7610 Rm 206 CMW. Muscles act in many organ systems. Muscles need a signal to contract. Muscle Anatomy. Motor Unit. Main Nerve. Nerve branch. Muscle. Skeletal Muscle. Smooth Muscle.

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Muscle physiology

Muscle Physiology

Summer Prematriculation Program

Summer 2004

Rahul Dave’

[email protected]

(312) 996-7610

Rm 206 CMW





Motor unit
MotorUnit

Main Nerve

Nerve branch

Muscle


Skeletal muscle
SkeletalMuscle




Cardiac muscle 2
Cardiac Muscle 2

Intercalated Disc



Sarcomere structure
Sarcomere Structure

M-line

Z-disc

H-zone

I-band

I-band

A-band



Other muscle proteins
Other Muscle Proteins

Brown Tropomyosin

Yellow Troponins

Blue Actin

Black Myosin Head Bind Site

Pink Myosin



Muscle structure
Muscle Structure

  • Describe the hierarchy of organization in muscle

  • Distinguish smooth, skeletal and cardiac muscle based on histology

  • Understand and rationalize the differences between fiber types

  • Know the skeletal muscle sarcomere structure cold.


Nerve muscle interface
Nerve-MuscleInterface




Smooth muscle nerve muscle interface
Smooth MuscleNerve-Muscle Interface


E c coupling smooth
E-C Coupling (Smooth)

Neurotransmitter

G

IP3 PIP2

Ca2+

SR



Muscle contraction
Muscle Contraction

  • Know each step in transmission across the neuromuscular junction

  • Know each step in E-C Coupling for striated muscle

  • Know each step in the cross-bridge cycle for striated muscle

  • Know the differences between smooth and striated (skeletal + cardiac) muscle


Preload and afterload
Preload and Afterload

Preload

The force (load) a muscle exerts prior to contraction.

Pre-contraction

Afterload

Force muscle exerts during contraction.

After [the start of] contraction

Demonstration




Exercise physiology
Exercise Physiology

These are all adaptations

  • Learning new motor patterns

  • Strength exercises: muscle hypertrophy

  • Endurance exercises: changes in muscle metabolism


Muscle diseases
Muscle Diseases

Metabolism

  • Lactic Acidosis

  • Glycogen Storage Diseases

    Muscle Function

  • Dilated Cardiomyopathy

  • Muscular Dystrophy

  • Malignant Hyperthermia

  • Neurologic

  • Hirschsprung’s disease

  • Myesthenia Gravis

  • Multiple Sclerosis

  • Parkinson’s Disease

  • Polio


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