Muscle physiology
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Muscle Physiology. Summer Prematriculation Program Summer 2004 Rahul Dave’. [email protected] (312) 996-7610 Rm 206 CMW. Muscles act in many organ systems. Muscles need a signal to contract. Muscle Anatomy. Motor Unit. Main Nerve. Nerve branch. Muscle. Skeletal Muscle. Smooth Muscle.

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Muscle Physiology

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Muscle Physiology

Summer Prematriculation Program

Summer 2004

Rahul Dave’

[email protected]

(312) 996-7610

Rm 206 CMW


Muscles act in many organ systems


Muscles need a signal to contract


Muscle Anatomy


MotorUnit

Main Nerve

Nerve branch

Muscle


SkeletalMuscle


Smooth Muscle


Cardiac Muscle 1


Cardiac Muscle 2

Intercalated Disc


3 Fiber Types


Sarcomere Structure

M-line

Z-disc

H-zone

I-band

I-band

A-band


Sliding Filament Theory


Other Muscle Proteins

BrownTropomyosin

YellowTroponins

BlueActin

BlackMyosin Head Bind Site

PinkMyosin


Smooth Muscle Structure


Muscle Structure

  • Describe the hierarchy of organization in muscle

  • Distinguish smooth, skeletal and cardiac muscle based on histology

  • Understand and rationalize the differences between fiber types

  • Know the skeletal muscle sarcomere structure cold.


Nerve-MuscleInterface


Excitation-Contraction Coupling


Cross Bridge Cycle


Smooth MuscleNerve-Muscle Interface


E-C Coupling (Smooth)

Neurotransmitter

G

IP3 PIP2

Ca2+

SR


Crossbridge Cycle (Smooth)


Muscle Contraction

  • Know each step in transmission across the neuromuscular junction

  • Know each step in E-C Coupling for striated muscle

  • Know each step in the cross-bridge cycle for striated muscle

  • Know the differences between smooth and striated (skeletal + cardiac) muscle


Preload and Afterload

Preload

The force (load) a muscle exerts prior to contraction.

Pre-contraction

Afterload

Force muscle exerts during contraction.

After [the start of] contraction

Demonstration


Frank-Starling Law


Force-Velocity Curve


Exercise Physiology

These are all adaptations

  • Learning new motor patterns

  • Strength exercises: muscle hypertrophy

  • Endurance exercises: changes in muscle metabolism


Muscle Diseases

Metabolism

  • Lactic Acidosis

  • Glycogen Storage Diseases

    Muscle Function

  • Dilated Cardiomyopathy

  • Muscular Dystrophy

  • Malignant Hyperthermia

  • Neurologic

  • Hirschsprung’s disease

  • Myesthenia Gravis

  • Multiple Sclerosis

  • Parkinson’s Disease

  • Polio


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