Muscle physiology
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Muscle Physiology. Summer Prematriculation Program Summer 2004 Rahul Dave’. [email protected] (312) 996-7610 Rm 206 CMW. Muscles act in many organ systems. Muscles need a signal to contract. Muscle Anatomy. Motor Unit. Main Nerve. Nerve branch. Muscle. Skeletal Muscle. Smooth Muscle.

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Muscle Physiology

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Muscle physiology

Muscle Physiology

Summer Prematriculation Program

Summer 2004

Rahul Dave’

[email protected]

(312) 996-7610

Rm 206 CMW


Muscles act in many organ systems

Muscles act in many organ systems


Muscles need a signal to contract

Muscles need a signal to contract


Muscle anatomy

Muscle Anatomy


Motor unit

MotorUnit

Main Nerve

Nerve branch

Muscle


Skeletal muscle

SkeletalMuscle


Smooth muscle

Smooth Muscle


Cardiac muscle 1

Cardiac Muscle 1


Cardiac muscle 2

Cardiac Muscle 2

Intercalated Disc


3 fiber types

3 Fiber Types


Sarcomere structure

Sarcomere Structure

M-line

Z-disc

H-zone

I-band

I-band

A-band


Sliding filament theory

Sliding Filament Theory


Other muscle proteins

Other Muscle Proteins

BrownTropomyosin

YellowTroponins

BlueActin

BlackMyosin Head Bind Site

PinkMyosin


Smooth muscle structure

Smooth Muscle Structure


Muscle structure

Muscle Structure

  • Describe the hierarchy of organization in muscle

  • Distinguish smooth, skeletal and cardiac muscle based on histology

  • Understand and rationalize the differences between fiber types

  • Know the skeletal muscle sarcomere structure cold.


Nerve muscle interface

Nerve-MuscleInterface


Excitation contraction coupling

Excitation-Contraction Coupling


Cross bridge cycle

Cross Bridge Cycle


Smooth muscle nerve muscle interface

Smooth MuscleNerve-Muscle Interface


E c coupling smooth

E-C Coupling (Smooth)

Neurotransmitter

G

IP3 PIP2

Ca2+

SR


Crossbridge cycle smooth

Crossbridge Cycle (Smooth)


Muscle contraction

Muscle Contraction

  • Know each step in transmission across the neuromuscular junction

  • Know each step in E-C Coupling for striated muscle

  • Know each step in the cross-bridge cycle for striated muscle

  • Know the differences between smooth and striated (skeletal + cardiac) muscle


Preload and afterload

Preload and Afterload

Preload

The force (load) a muscle exerts prior to contraction.

Pre-contraction

Afterload

Force muscle exerts during contraction.

After [the start of] contraction

Demonstration


Frank starling law

Frank-Starling Law


Force velocity curve

Force-Velocity Curve


Exercise physiology

Exercise Physiology

These are all adaptations

  • Learning new motor patterns

  • Strength exercises: muscle hypertrophy

  • Endurance exercises: changes in muscle metabolism


Muscle diseases

Muscle Diseases

Metabolism

  • Lactic Acidosis

  • Glycogen Storage Diseases

    Muscle Function

  • Dilated Cardiomyopathy

  • Muscular Dystrophy

  • Malignant Hyperthermia

  • Neurologic

  • Hirschsprung’s disease

  • Myesthenia Gravis

  • Multiple Sclerosis

  • Parkinson’s Disease

  • Polio


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