Misconduct Case Study. Our story so far : Peter:4 th -year grad. student makes mice lacking SLAM gene several cell types have abnormal function Sally:4 th -year grad. student moved onto Peter’s project to speed up cell function analysis
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Our story so far:
Peter:4th-year grad. student
makes mice lacking SLAM gene
several cell types have abnormal function
Sally:4th-year grad. student
moved onto Peter’s project to speed up cell function analysis
1st experiment: SLAM affects blood-cell function
2nd experiment:reports possibly switched samples
recovers from error, same result as 1st experiment
In order to avoid creating conflict in the lab, Peter wrote up the manuscript using Sally’s graph. The manuscript was published in Nature, and created quite a stir in the scientific community.
However, in the next six months, Peter was dismayed to read several publications by competing labs that contradicted Sally’s data. It had even been suggested at a national conference that Dr. Larson’s lab had performed their experiments poorly or had misrepresented their data. Peter now felt certain that Sally had falsified her data.
Sialic acid: usually terminal carbohydrate on glycoprotein or glycolipid, attached to galactose or GalNAc by a-2,3 or a-2,6 linkage