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THE MUSCULAR SYSTEM. What do you already know about muscle tissue? What is the definition of an organ?. Types of muscle tissue. Skeletal muscle Cardiac muscle Smooth muscle. Functions. Producing body movements by changing chemical energy into mechanical energy Stabilizing body positions

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The muscular system

THE MUSCULAR SYSTEM

What do you already know about muscle tissue?

What is the definition of an organ?


Types of muscle tissue
Types of muscle tissue

  • Skeletal muscle

  • Cardiac muscle

  • Smooth muscle


Functions
Functions

  • Producing body movements by changing chemical energy into mechanical energy

  • Stabilizing body positions

  • Generating heat

  • Moving substances

    Within the body


Skeletal muscle anatomy
Skeletal muscle anatomy

  • Connective tissue around muscle (epimysium)

    • Extends to form tendon (dense regular connective tissue) – connects muscle to periosteum of bone



  • Myofibrils= contractile organelles surrounded by perimysium stripes

  • Sarcoplasmic reticulum - encircles myofibrils= similar to smooth ER; function = stores calcium

  • Filaments (thin and thick)– inside myofibrils; don’t extend length of fiber; contained in sarcomeres


Anatomy of muscle fiber
Anatomy of muscle fiber surrounded by perimysium

  • No mitosis

  • Growth: hypertrophy due to hormones (testosterone, HGH)

  • Sarcolemma = cell membrane

  • Sarcoplasm = cytoplasm (glycogen!!)

  • Myoglobin – a protein = binds with/release O2 for the mitochondria

  • Mitochondria = many!


Don t write
Don’t write surrounded by perimysium

  • Review:

    • Sarcolemma

    • Sarcoplasm

    • Sarcoplasmic reticulum

    • Myofibrils

    • filaments


How a muscle contracts
HOW A MUSCLE CONTRACTS surrounded by perimysium

http://www.youtube.com/watch?v=ren_IQPOhJc&list=PL7DDED4766451C09D


  • A neuron connects to a muscle fiber [called the neuromuscular junction (NMJ)]

  • Arrival of nerve impulse causes release of acetylcholine (ACh: a neurotransmitter – a chemical).

  • ACh diffuses to receptors on muscular membrane (sarcolemma), opening a Na+ ion channel, causing Na+ to enter the muscle fiber


Muscle contraction cont
Muscle contraction cont neuromuscular junction (NMJ)]

  • Causes muscle action potential due to change in membrane potential (b/c of addition of Na+ )

  • Sarcoplasmic reticulum releases stored Ca+2 into sarcoplasm

  • Causes muscle contraction (sliding filament mechanism):

    • Unblocks actin (thin) so myosin (thick) heads can bind to them

    • Filaments slide past one another, shortening the muscle


Sliding filament mechanism neuromuscular junction (NMJ)]


Sliding filament mechanism
Sliding filament mechanism neuromuscular junction (NMJ)]

  • Lengths of filaments do not change

  • Sarcomere shortens

  • Causes shortening of muscle fiber and muscle


Plants drugs effect nmj
Plants/drugs effect NMJ neuromuscular junction (NMJ)]

  • Botulinum toxin from bacterium Clostridium botulinum blocks exocytosis of ACh

  • Curare – plant derivative – used on arrow/blowgun darts. Binds to/blocks ACh receptors


Muscle physiology
Muscle physiology neuromuscular junction (NMJ)]

  • Muscles tug on tendons which pull on bones

  • One bone is pulled towards another

  • Insertion towards origin

  • Most cross a joint


Muscle groups
Muscle groups neuromuscular junction (NMJ)]

  • Prime mover and antagonist

  • Opposite actions

  • Switch roles

  • Opposite sides of bone/joint


Lever systems
Lever systems neuromuscular junction (NMJ)]

  • Most of the bones of the limbs (arms & legs) act as levers. These levers are powered by muscles.

  • A lever is a rigid rod able to rotate about a fixed point known as a fulcrum, formed by the joint. Any force applied to the lever is called the effort.

  • A force that resists the motion of the lever, such as the downward force exerted by a weight on the bar, is called the load or the resistance.

  • The contraction of the muscles is the effort and the part of the body concerned is known as the resistance or load.

  • Bones of the body act as levers (a mechanical device) which create a mechanical advantage of strength or speed.


Muscle contraction
Muscle contraction neuromuscular junction (NMJ)]

  • Muscle fibers: all-or-none

  • Strength of muscle contraction: depends on # of contracting fibers

  • Affects energy usage


Providing energy
Providing energy neuromuscular junction (NMJ)]

  • ATP broken down during contraction

  • Store little ATP, must produce it

  • 3 ways:

    • Aerobic respiration: slow, requires O2, lots ATP

    • Anaerobic glycolysis and lactic acid formation: faster, no O2 needed, less ATP

    • Creatine phosphate and ADP: CP not found in other cells, very fast, doesn’t last


Muscle fatigue
Muscle fatigue neuromuscular junction (NMJ)]

  • no contraction even with stimulation - occurs from oxygen debt (lactic acid builds up and ATP runs low)


Types of muscle contractions
Types of muscle contractions neuromuscular junction (NMJ)]

  • Isotonic: with movement

  • Isometric: muscle against immovable (or almost) object


Effect of exercise
Effect of exercise neuromuscular junction (NMJ)]

  • Aerobic (endurance): results in muscles with resistance to fatigue.

  • Resistance (isometric) training: enlarged muscles


In review don t write
In review……… neuromuscular junction (NMJ)](don’t write)

  • Lifting weights is an example of resistance or endurance training?

  • The reaction of creatine phosphate and ADP generates ATP quickly or slowly?

  • The ability of your body to use oxygen to produce ATP is _____ respiration.

  • True or False: The strength of a muscle contraction is determined by the amount of muscle fibers that are contracting.


Don t write1
Don’t write neuromuscular junction (NMJ)]

  • The strength of a muscle contraction depends on what?

  • What is the relationship between the strength of a muscle contraction and energy usage?

  • Muscle fatigue is due to ____ debt


Example
example neuromuscular junction (NMJ)]

  • Running a 100 yd dash in 12 seconds requires 6L of oxygen.

  • But the max amount that could be delivered and used by your muscles (VO2 max) would be 1.2 L

  • Oxygen debt?

  • = 4.8L


The point
THE POINT neuromuscular junction (NMJ)]

  • The more oxygen your body can take in and use determines your endurance


Don t write2

Why are some people better at endurance activities? neuromuscular junction (NMJ)]

Why are some people FAST?

Is it genetic? Is it training?

DON’T WRITE


Types of muscle fibers
Types of muscle fibers neuromuscular junction (NMJ)]

  • 1. Slow oxidative fibers

    • Little power (small in diameter); fatigue resistant; many mitochondria. Adapted for maintaining posture & endurance activities

  • 2. Fast oxidative-glycolytic fibers

    • Intermediate in diameter, faster than #1 but briefer in duration. Adapted for: walking/sprinting

  • 3. Fast glycolytic fibers

    • Large diameter (contract strongly/quickly); tire quickly; large amount lactic acid build up

    • Short, rapid, intense movement

    • Adapted for intense anaerobic movements of short duration: weight lifting/throwing a ball


Muscle fibers in muscles
muscle fibers in muscles neuromuscular junction (NMJ)]

  • Muscle are a combo of different fibers

  • Proportion of fibers is individual


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