Preformulation considerations in biopharmaceutics

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Topics. DissolutionpHPolymorphismParticleIonic formPharmceutical examplesGriseofulvin, nitrofurantoin, erythromycin. Dissolution rate. pH partition hypothesisDeveloped for drugs in solutionBut many drugs are given orally as solidsSolubilityDoes solubility always predict dissolution rate?T

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Preformulation considerations in biopharmaceutics

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