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Publication. Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613. Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer. Sweden Mammography Cohort.

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publication

Publication

Cho, E., et al., Alcohol Intake and Colorectal Cancer: A Pooled Analysis of 8 Cohort Studies. Annals of Internal Medicine, 2004; 140: 603-613.

slide2

Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer

Sweden Mammography Cohort

Canadian National Breast Screening Study

Netherlands

Cohort Study

Nurses’ Health Study

Health Professionals Follow-up Study

New York

State Cohort

Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

Total = 489,979 # of cases = 4,687

Iowa Women’s Health Study

Cho, et al., 2004

cohort studies in the pooled analysis of alcohol and colorectal cancer
Cohort Studies in the Pooled Analysis of Alcohol and Colorectal Cancer

Study Total # of cohort cases

ATBC 26,987 184

Canadian National Breast 56,837 284 Screening Study

Health Professionals 47,673 408 Follow-up Study

Iowa Women’s Health Study 34,603 796

Netherlands Cohort Study 120,852 1126

New York State Cohort 52,913 789

Nurses’ Health Study (a) 88,651 220

Nurses’ Health Study (b) 68,540 420

Sweden Mammography Cohort 61,463 460

Cho, et al., 2004

total alcohol intake
Total Alcohol Intake

Study % Drinkers Mean* (SD) (g/d) ATBC 89 20.3 (21.8) Canadian National 77 10.9 (14.5) Health Professionals 76 14.8 (16.1) Iowa Women’s 45 8.7 (12.3) Netherlands Study (W) 68 8.5 (10.6) Netherlands Study (M) 85 17.3 (16.7) New York State Cohort (W) 78 6.0 (9.4) New York State Cohort (M) 89 12.1 (17.1) Nurses’ Health Study (a) 68 9.4 (11.6) Nurses’ Health Study (b) 64 9.6 (12.1) Sweden Mammography Cohort 67 3.5 (3.5) *Among drinkers only

Cho, et al., 2004

alcohol and colorectal cancer
Alcohol and Colorectal Cancer

Intake No. of Multivariate RR (g/d) cases (95% CI)

0 1,466 1.00 (ref)

>0-<5 1,475 0.94 (0.86-1.03)

5-<15 849 0.97 (0.88-1.06)

15-<30 485 1.01 (0.86-1.18)

30-<45 244 1.16 (0.99-1.36)

>45 168 1.41 (1.16-1.72)

P for trend <0.001

Cho, et al., 2004

study specific relative risks for colorectal cancer for alcohol intake 30 vs 0g d
Study-Specific Relative Risks for Colorectal Cancer for Alcohol Intake > 30 vs. 0g/d

Cho, et al., 2004

alcohol intake and colorectal cancer by tumor site
Alcohol Intake and Colorectal Cancer by Tumor Site

RR (95% CI) Intake (g/d) Colon Rectum

0 1.00 1.00

>0 - <5 0.92 1.01

5 - <15 0.94 0.99

15 - <30 1.01 1.05

30 - <45 1.08 1.42

>45 1.45 1.49 (1.14-1.83) (1.04-2.12)

P for trend <0.001 0.006

Cho, et al., 2004

alcoholic beverages and colorectal cancer
Alcoholic Beverages and Colorectal Cancer

Intake Beer Wine Liquor (g/d)

0 1.00 1.00 1.00

>0-<30 1.01 0.97 0.98

>30 1.37 1.82 1.21 (1.00-1.87) (1.28-2.59) (0.99-1.47)

P for trend 0.2 0.001 0.1

Cho, et al., 2004

alcoholic beverages and colorectal cancer by tumor site
Alcoholic Beverages and Colorectal Cancer by Tumor Site

Alcoholic Tumor RR (95% CI) beverage site (>15 vs. 0 g/d)

Beer Colon 1.38 (1.05-1.82)

Rectum 1.59 (1.12-2.25)

Wine Colon 1.33 (1.00-1.77)

Rectum 1.55 (1.11-2.17)

Liquor Colon 1.06 (0.86-1.30)

Rectum 1.10 (0.85-1.41)

For each beverage, the differences by tumor site were not statistically significant.

Cho, et al., 2004

alcohol and colorectal cancer by body mass index
Alcohol and Colorectal Cancer by Body Mass Index

*

Relative Risk

P for interaction=0.03

0 >0- <5 5-<15 15-<30 >30

*P<0.05

Alcohol (g/d)

BMI <22

22-<25

25+ kg/m2

Cho, et al., 2004

alcohol and colorectal cancer by multivitamin use
Alcohol and Colorectal Cancer by Multivitamin Use

*

Relative Risk

P for interaction >0.2

0 >0-<5 5-<15 15-<30 >30

Alcohol (g/d)

*P<0.05

Users

Nonusers

Cho, et al., 2004

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