Biomedical applications of molecular imaging
This presentation is the property of its rightful owner.
Sponsored Links
1 / 46

Biomedical applications of molecular imaging PowerPoint PPT Presentation


  • 166 Views
  • Uploaded on
  • Presentation posted in: General

Biomedical applications of molecular imaging. Tony Lahoutte UMons Nov-Dec 2011. Course 1. Part 1: Introduction and general principles. Biomedical Imaging. R önt gen. Hand of Anna Berthe 1895. Biomedical Imaging. R önt gen. 22 dec 1895 Hand of Anna Berthe. 23 January 1896

Download Presentation

Biomedical applications of molecular imaging

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Biomedical applications of molecular imaging

Biomedical applications of molecular imaging

Tony Lahoutte

UMons

Nov-Dec 2011


Course 1

Course 1

Part 1: Introduction and general principles


Biomedical applications of molecular imaging

Biomedical Imaging

Röntgen

Hand of Anna Berthe

1895


Biomedical applications of molecular imaging

Biomedical Imaging

Röntgen

22 dec 1895

Hand of Anna Berthe

23 January 1896

Hand of Albert von Kölliker


Biomedical applications of molecular imaging

Biomedical Imaging

Weissleder and Pittet, Nature 2009


Biomedical applications of molecular imaging

Biomedical Imaging

1. Microscopy: In vitro samples or in vivo tissues

2. Preclinical Imaging:

In vivo imaging in animal models

3. Clinical Imaging: Imaging in patients


Biomedical applications of molecular imaging

CT – X-ray

MRI

SPECT & PET

Bioluminescence

Fluorescence

FRET/FRAP

ImageStream

Biomedical Imaging

www.mi-central.org


Biomedical applications of molecular imaging

Biomedical Imaging

Anatomy

Physiology

Cell

Molecular

Anatomical imaging: Organ and tissue morphology

Physiologic Imaging: Organ and tissue function

Molecular Imaging: Molecules and cells


Biomedical applications of molecular imaging

Molecular Imaging

  • Definition:

    • Molecular imaging is the visualization, the characterization and the measurement of biological processes at the molecular and cellular levels in living systems


Biomedical applications of molecular imaging

Hybrid Imaging

Anatomical

Molecular


Biomedical applications of molecular imaging

Anatomical

CT scan

of a women


Biomedical applications of molecular imaging

Molecular

Glucose

molecules


Biomedical applications of molecular imaging

PET-CT scan

  • Computed Tomography

  • or CT scan

    • Anatomical

Positron Emission Tomography

or PET scan

  • Molecular


Biomedical applications of molecular imaging

Anatomical + Molecular

PET/CT

fusion

image


Biomedical applications of molecular imaging

Anatomical


Biomedical applications of molecular imaging

Molecular

Radiolabeled antibody fragments that recognize cancer cells


Biomedical applications of molecular imaging

SPECT-CT


Biomedical applications of molecular imaging

Anatomical + Molecular

SPECT/CT

fusion

image


Biomedical applications of molecular imaging

Anatomical

MRI scan


Biomedical applications of molecular imaging

Anatomical + Molecular


Biomedical applications of molecular imaging

PET/MRI scanner

Courtesy of University of Tübingen


Biomedical applications of molecular imaging

FMT/MRI

FMT

MRI

Fluorescence Molecular Tomography/ Magnetic Resonance Imaging

=

FMT/MRI

J. Chen, JCI, 2009: “Combined magnetic resonance and fluorescence imaging

of the living mouse brain reveals glioma response to chemotherapy”


Biomedical applications of molecular imaging

FMT/CT

FMT/CT fusion

Nature 2008;452:580-589


Biomedical applications of molecular imaging

FMT scanner

Imaging Near Infrared Fluorescence

Visen


Biomedical applications of molecular imaging

Anatomical + Molecular

PET/CT

SPECT/CT

PET/MRI

FMT/MRI

FMT/CT

=

Hybrid imaging


Biomedical applications of molecular imaging

Physiological Imaging

  • = Functional Imaging

  • visualizing cardiac contraction

  • Imaging blood perfusion

  • ...


Biomedical applications of molecular imaging

Planar and Tomographic Imaging

Planar = 2D projection

Tomographic = 3D volume


Biomedical applications of molecular imaging

Planar and Tomographic Imaging

Gamma Camera


Biomedical applications of molecular imaging

Planar and Tomographic Imaging

Anterior and posterior view of a

planar bone scintigraphy

Planar = 2D projection


Biomedical applications of molecular imaging

Planar and Tomographic Imaging

Tomographic = 3D volume


Biomedical applications of molecular imaging

Static and Dynamic Imaging

Static image= 1 time interval

Dynamic image = multiple time intervals


Biomedical applications of molecular imaging

Static and Dynamic Imaging

Static image of a radiolabeled antibody between 1-10 s after intravenous injection in a rat

Static image = 1 time interval


Biomedical applications of molecular imaging

Static and Dynamic Imaging

Dynamic image of a radiolabeled antibody between 1second and 10 min after intravenous injection in a rat. Every frame is 10 seconds

Dynamic image = multiple time intervals


Biomedical applications of molecular imaging

Special case of dynamic: Gated Image

Gated image = images are synchronized with cardiac contraction or respiration


Biomedical applications of molecular imaging

Special case of dynamic: Gated Image

Gated image = images are synchronized with cardiac contraction or respiration


Biomedical applications of molecular imaging

Static and Dynamic Imaging

Different combinations are possible:

Static planar image

Dynamic planar image

Static tomographic image

Dynamic tomographic image


Biomedical applications of molecular imaging

Slicing and orientation


Biomedical applications of molecular imaging

Slicing and orientation

A

Sagittal

R

L

A

L

R

Coronal

Transverse


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

Slicing and orientation

R

L

Orientation: we look from the feet to the head


Biomedical applications of molecular imaging

End of part 1


  • Login