Block 5
This presentation is the property of its rightful owner.
Sponsored Links
1 / 10

Block 5 PowerPoint PPT Presentation


  • 71 Views
  • Uploaded on
  • Presentation posted in: General

Block 5. CASE 5. Gabatino-Labra. CASE 5. Patient is a known schizophrenic maintained on Chlorpromazine 100 mg per orem 2x/day for 6 months . Two weeks prior to consult, he was prescribed Propranolol 40 mg/tablet 2 tablets 3x/day. QUESTION. What caused the symptoms of the patient?.

Download Presentation

Block 5

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Block 5

Block 5

CASE 5

Gabatino-Labra


Block 5

CASE 5


Block 5

  • Patient is a knownschizophrenic

  • maintained on Chlorpromazine

    • 100 mg per orem 2x/day for 6 months.

  • Two weeks prior to consult, he was prescribed Propranolol

    • 40 mg/tablet 2 tablets 3x/day.


Question

QUESTION

  • What caused the symptoms of the patient?


Block 5

Chlorpromazine


Metabolism

Metabolism

Chlorpromazine

CYP 2D6

typically degraded by the liver by the action of cytochrome-P450 family enzymes, usually CYP2D6

  • 7-hydroxylation


Block 5

Propranolol


Metabolism1

Metabolism

Propranolol

CYP 2D6

  • aromatic hydroxylation

4-hydroxy propranolol is a weak inhibitor of CYP2D6


Drug interaction

Drug Interaction

70%

Propranolol

Chlorpromazine


Drug interaction1

Drug Interaction


  • Login