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1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD

NS1 Spring 2012. Lecture Order. 1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD. Trends Neurosci. 25:578, 2002. J. Neurosci. 19:6298, 1999. TINS 30:407, 2007. Control of NMDA surface expression through ER retention signal. Tubulin -> Microtubules

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1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD

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  1. NS1 Spring 2012 Lecture Order 1) Receptor Trafficking • Scaffolding Proteins at the PSD • Signaling at the PSD

  2. Trends Neurosci. 25:578, 2002

  3. J. Neurosci. 19:6298, 1999

  4. TINS 30:407, 2007

  5. Control of NMDA surface expression through ER retention signal

  6. Tubulin -> Microtubules Actin -> Microfilaments <----Dynamic polymers <----Stable, only in neurons Neurofilaments -> NF-H, -M, -L Nature Reviews Neurscience 10:319, 2009

  7. Nature Reviews Neurscience 10:319, 2009

  8. Nature Reveiws MolCelBio 10:682, 2009

  9. Science 279:519, 1998

  10. cargo

  11. minus-end directed motor plus-end directed motor

  12. Axoneme Assay plus-end directed motor: axoneme travels toward stable tail (-) minus-end directed motor: axoneme travels toward unstable head (+) Science 288:1796, 2000 Nature 347:780, 1990

  13. http://mc11.mcri.ac.uk/wrongtrousers.html http://mc11.mcri.ac.uk/wrongtrousers.html

  14. http://www.scripps.edu/milligan/

  15. Microtubule Motility Assay (plus directed motor) YFP-KIF17

  16. J. Neurosci. 23:131, 2003 http://www.pnas.org/cgi/content/full/222371099/DC1/1

  17. Nature Neurosci. 3:415, 2000

  18. Role of endocytosis of ion channels in regulating synaptic efficacy Science 285:215, 1999

  19. Nature Rev. Neurosci. 1:161, 2000

  20. TINS 31:559, 2008

  21. AMPA receptors and LTP/LTD

  22. Nature Rev. Neurosci. 2:315, 315

  23. Neuron 36:435, 2002

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