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NS1 Spring 2012. Lecture Order. 1) Receptor Trafficking Scaffolding Proteins at the PSD Signaling at the PSD. Trends Neurosci. 25:578, 2002. J. Neurosci. 19:6298, 1999. TINS 30:407, 2007. Control of NMDA surface expression through ER retention signal. Tubulin -> Microtubules

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NS1 Spring 2012

Lecture Order

1) Receptor Trafficking

  • Scaffolding Proteins at the PSD

  • Signaling at the PSD






Tubulin -> Microtubules signal

Actin -> Microfilaments

<----Dynamic polymers

<----Stable, only in neurons

Neurofilaments -> NF-H, -M, -L

Nature Reviews Neurscience 10:319, 2009





cargo signal


minus-end directed signal

motor

plus-end directed

motor


Axoneme Assay signal

plus-end directed motor:

axoneme travels toward

stable tail (-)

minus-end directed motor:

axoneme travels toward

unstable head (+)

Science 288:1796, 2000

Nature 347:780, 1990


http://mc11.mcri.ac.uk/wrongtrousers.html signal

http://mc11.mcri.ac.uk/wrongtrousers.html



Microtubule Motility Assay signal

(plus directed motor)

YFP-KIF17


J. Neurosci. 23:131, 2003 signal

http://www.pnas.org/cgi/content/full/222371099/DC1/1









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