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Retinoblastoma

Retinoblastoma. History. 1600s – scary story of death 1800s – story of a threatened child blinded but saved by enucleation 1900s – fairy tale where most children survive and many regain vision 2000s – Near complete understanding of the disease Future –. Therapeutic options.

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Retinoblastoma

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  1. Retinoblastoma

  2. History • 1600s – scary story of death • 1800s – story of a threatened child blinded but saved by enucleation • 1900s – fairy tale where most children survive and many regain vision • 2000s – Near complete understanding of the disease • Future –

  3. Therapeutic options • 1800s- enucleation • 1990s- chemotherapy • Radiotherapy • Chemoreduction followed by thermo / cryotherapy

  4. Both chromosomes - normal

  5. Germinal mutationOne chromosome- abnormal

  6. Somatic mutationthe other chromosome- abnormal

  7. Presentation

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