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水溶性维生素 PowerPoint PPT Presentation


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水溶性维生素. 水溶性维生素: VB 1 ( 硫胺素 ) VB 2 ( 核黄素 ) VB 6 ( 吡哆醇 ) VB 12 ( 氰钴胺素 ) VC( 抗坏血酸 ) 烟酸 ( 尼克酸 ) 叶酸、泛酸、胆碱 、生物素等。. 水溶性维生素的共同特点. (1) 化学组成除碳、氢、氧外尚有氮、 硫、钴等元素。 (2) 溶于水而不溶于脂肪及脂溶剂。 (3) 在满足了组织需要后,多余的将由 尿排出。 (4) 没有非功能性的单纯储存形式,在

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水溶性维生素

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VB1()

VB2()

VB6()

VB12()

VC()

()


(1)

(2)

(3)

(4)


(5)

(

)

(6)

(7)

(8)


B1

B12697

1897Eijkman


1911FunkLister(amine)(Vital-amine)


1926JansenDonathB1(aneurin)

1936WilliamsB1B1


B1

B1100pH5120pH 3140 1pH>7


121mg


90-150g 0.6mg01mg


1 :

B1(ATP) TPP)B1 TPP-,


2

B1B1


3 B1TPP(TTP)TTP

4.


B1

1.

2.

3.


B1

B1B1


1.


.


2.:

3.

4.

25VB1


5. )


)

66ug

) TPP TPP

15


VB1



  • 30-40


B1


B2( Riboflavin)

19

1933(FAD)(FMN)B6


  • (FAD)FMN)

  • 240~(22800C27.50C100mL12mg



  • FMNFDAFMNFDA



  • CuZnFe


  • 60-70

  • (5120gL)


  • 1


2FDAFMNB6

3FDA(GSSG)(GSH)

4P450


FAD


  • 1.


  • 2.

  • 3.


  • 4.

  • BB6




  • 60ms116m9


FMNFAD1135



5.

0.5mg1000kcal1.4mg

1.2mg


B2


B6

  • Gyorgy1934B61938B61939

  • B6B6B6


  • B62-3--5-(PN),(PL)(PM)B6


  • B6

  • pHB6

  • 4-

  • D6


  • B6 B6


  • B6

  • D6 B6


VB6PLP

VB6

VB6PLP100

VB65.

PLPPLP


  • VB6B12

  • ,PLP

    B6 B6D6

    B6 PLP

  • 5-7

    B6(CHD)


  • D6B6

  • 2050PL

  • B6


  • PLP


  • VB6


B6

  • B6(

  • )()


  • PPB5

  • 1867Huber

  • 70

  • 1913Funk

  • 20


  • 191320Goldberger

  • 1937Elvehjem()


  • 251g60ml80mllg1m11.5ml


1(CoINADI)(CoNADP )


2 : (glucosetolerancefactorGTF)

3 :

-


  • (dermatitis)(diarrhea)(depression)D3D'


1


  • 2

  • 3


NAD+NADP +l00ml128338gl00ml20-100g


  • (NE)

  • 60mg1mg

    (mgNE)(mg)+160(mg)


  • 12N1- 2

  • 3

  • ()NADHNADPH


  • 301000msd


  • 1000kcalmg


  • 80-90


  • ()


  • (folic acid)B

  • 1941Mitchell

  • 1998(FDA1.4mg/kg)


  • 785678


  • 1005090


  • 60 g/d60 g

  • C


  • DNARNA




  • (50gd)20



B12

  • B12(1F)


  • B12B12a-56 B12


  • B12 B12(IF) TcB12


  • B122-3mg

  • B12B126B12B122-3


  • B12B12B12

  • 1

  • 2A


  • 1 B12B12B12


B12

B125510DNA


  • B6B12B12


B12


()B12

()(B12)

)

()B12


  • 100gB12


  • B12B12


  • B3,.

  • 1931Ringrose

  • 1933Williams

  • 1939Williams

  • 1950CoA


  • (26)

    pH5-7


  • A4060

  • A

  • ([I15)CO2


  • A AAAAA


  • AA (HSCoA)3 .



  • 100



  • AI



  • HR

  • 40

  • 1901Wildiem19161927BatemanBoas

  • 19333llisonR


  • 1936KR1Tonnis1937

  • GyorgyH

  • 1940GyorgyRH


  • 1942du Vigneaud

  • 1943


  • 8




  • -

  • CO2

  • I


  • 106




  • FNBA1



  • (choline)1849Strecker

  • 18621866

  • 1941Devigneaud

  • 1940SuraGyorgy Goldblatt


  • 2030


  • (-)HOCH2CH2N(CH3)3





  • 10


  • 12-171630()()()


  • (apoptosls)




3()



  • (EAR)(RNl)

  • FNBA1A1500mgd




C

  • C1550450C

  • 1497Vascvo da Gama160100

  • 1740Anson61955451051


  • 1516

  • 1747(JLind)1795


  • 1928AlbertSzent-GyisrgyiC6H8O6

  • 1932KingWaugh

  • 1933Howo~hHirstCReichsteinCC


  • C6HC

  • LD2



  • CC


  • C

  • C

  • C


  • (1)(2)(3)4)

  • PbHgCdAsC

  • CN


  • CNADH


  • C300mg


  • 1 C

  • 47

  • 61


  • 2


  • 3


  • 4 C


  • CC-2-


  • c

  • 1C CCC 2C C4


  • CC 2g1gC


CCCC


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