The Universal Theory of Medicine of Hans Selye
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The Universal Theory of Medicine of Hans Selye. The Stress Repair Mechanism (SRM). COGNITIVE PATHWAY. Visual, Olfactory Auditory, Tactile. Cerebral Cortex. HPA Axis. CAPILLARY GATE COMPONENT Stressful Stimuli Intravascular Neurons Pathways. TISSUE REPAIR COMPONENT. Surgery Trauma

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The Universal Theory of Medicine of Hans Selye

The Stress Repair Mechanism (SRM)

COGNITIVE PATHWAY

Visual, OlfactoryAuditory, Tactile

Cerebral Cortex

HPA Axis

CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways

TISSUE REPAIR COMPONENT

Surgery

Trauma

BurnsSepsisRadiationChemicalsToxins

Anesthesia

EmotionalMechanisms

StressfulForcesExtravascularTissue Disruption

EpinephrineNorepinephrineCortisol

Hypothalamus

Pain

SYMPATHETIC

Internuncial

Nociception

VASCULARENDOTHELIUM

PARASYMPATHETIC

Krebs Cycle

Spinal Cord

Tissue Factor Pathway InhibitorATIIIProtein C

Insulin

NitricOxide

ThrombinAmplificationFactor IX

Peripheral Nerves

ATP

Ca+

ThrombinAcceleration

Analgesia

Thrombin Activation

TISSUE FACTOR

PAI

TPA

Factor VII

THROMBIN

Factor VIIIC

VON WILLIBRAND FACTOR

PeripheralReceptors

TAFI

FIBRONIGEN

Factor X

Sensory Stressors

FibrinSplit Products

Insoluble Fibrin

SOLUBLEFIBRIN

Factor XIII

SPINAL PATHWAY

Fibronectin

Vitronectin

TISSUEREPAIR

COAGULATION

PlateletsInflammationChemotaxisMitosis

SYSTOLICTURBULENTRESISTANCE

PusScabsCastsExudates

Abscesses

CAPILLARYFLOW

CAPILLARYHEMOSTASIS

SYSTOLICLAMINARFLOW

TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen

ImmuneProteins

MetabolismAngiogenesisChemokinesCytokinesProstaglandins

Malignancy

Apoptosis

HyperviscosityHypercoagulableFlow ResistanceIncreased SWR

Cardiac WorkHypertensionDecreased CO

Atherosclerosis

Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity

Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR

Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR

BoneMuscle

PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF

FibrosisScarAdhesion



Fundamentals of stress theory
Fundamentals of Stress Theory

  • DNA + Stress Mechanism + embryological development?

  • Capillary Gate Theory ?

  • Clot formation?

  • Unified Tissue Repair Theory?

  • Coagulation Cascade

  • Mechanisms can now be described for all these old theories!!

  • It is the function of science to discover the existence of a general reign of order in nature and to find the causes governing this order.


Factor viii the odd couple
Factor VIII: The Odd Couple

Von Willebrand’s Factor

Vascular Endothelium

Inert

Fluctuates with Nervous activity

Gigantic molecule

Factor VIIIC

liver

Labile enzyme

Generates Insoluble Fibrin

Gigantic molecule


Capillary Gate Theory

Coagulation Cascade

Tissue Repair Theory

Autonomic Nervous System

Vascular Endothelium

Stress Repair Mechanism


Autonomic Nervous System

The Coagulation Cascade

Capillary

Gate

Component

Tissue Repair Component

Soluble

Fibrin

Insoluble Fibrin


The Universal Theory of Medicine of Hans Selye

The Stress Repair Mechanism (SRM)

COGNITIVE PATHWAY

Visual, OlfactoryAuditory, Tactile

Cerebral Cortex

HPA Axis

CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways

TISSUE REPAIR COMPONENT

Surgery

Trauma

BurnsSepsisRadiationChemicalsToxins

Anesthesia

EmotionalMechanisms

StressfulForcesExtravascularTissue Disruption

EpinephrineNorepinephrineCortisol

Hypothalamus

Pain

SYMPATHETIC

Internuncial

Nociception

VASCULARENDOTHELIUM

PARASYMPATHETIC

Krebs Cycle

Spinal Cord

Tissue Factor Pathway InhibitorATIIIProtein C

Insulin

NitricOxide

ThrombinAmplificationFactor IX

Peripheral Nerves

ATP

Ca+

ThrombinAcceleration

Analgesia

Thrombin Activation

TISSUE FACTOR

PAI

TPA

Factor VII

THROMBIN

Factor VIIIC

VON WILLIBRAND FACTOR

PeripheralReceptors

TAFI

FIBRINOGEN

Factor X

Sensory Stressors

FibrinSplit Products

Insoluble Fibrin

SOLUBLEFIBRIN

Factor XIII

SPINAL PATHWAY

Fibronectin

Vitronectin

TISSUEREPAIR

COAGULATION

PlateletsInflammationChemotaxisMitosis

SYSTOLICTURBULENTRESISTANCE

PusScabsCastsExudates

Abscesses

CAPILLARYFLOW

CAPILLARYHEMOSTASIS

SYSTOLICLAMINARFLOW

TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen

ImmuneProteins

MetabolismAngiogenesisChemokinesCytokinesProstaglandins

Malignancy

Apoptosis

HyperviscosityHypercoagulableFlow ResistanceIncreased SWR

Cardiac WorkHypertensionDecreased CO

Atherosclerosis

Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity

Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR

Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR

BoneMuscle

PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF

FibrosisScarAdhesion





Francis crick 1916 2004 james watson 1928
Francis Crick 1916-2004James Watson 1928-?


The vascular endothelium
The Vascular Endothelium

TF

SNS

TF

VWF

PNS

NO

TF


Thrombin the universal enzyme of energy transformation
Thrombin: The Universal Enzyme of Energy Transformation

  • Transforms ATP into cell and enzyme effects

  • Requires Ca+

  • Parathyroid glands regulate Ca+ to optimize thrombin activity

  • Energizes all tissue repair activities

  • Converts fibrinogen into soluble and insoluble fibrin

  • Clot formation, inflammation, mitosis, metabolism, angiogenesis & all other aspects of tissue repair

  • Chemokines, cytokines, prostaglandins for cell communications that coordinate the stages of tissue repair

  • Thrombin elevations cause malignancy

  • Thrombin declines trigger apoptosis

  • Vascular Endothelium regulates thrombin in healthy tissues

  • Red clot governs thrombin levels in healing tissues




The Universal Theory of Medicine of Hans Selye

The Stress Repair Mechanism (SRM)

COGNITIVE PATHWAY

Visual, OlfactoryAuditory, Tactile

Cerebral Cortex

HPA Axis

CAPILLARY GATE COMPONENTStressful StimuliIntravascularNeurons Pathways

TISSUE REPAIR COMPONENT

Surgery

Trauma

BurnsSepsisRadiationChemicalsToxins

Anesthesia

EmotionalMechanisms

StressfulForcesExtravascularTissue Disruption

EpinephrineNorepinephrineCortisol

Hypothalamus

Pain

SYMPATHETIC

Internuncial

Nociception

VASCULARENDOTHELIUM

PARASYMPATHETIC

Krebs Cycle

Spinal Cord

Tissue Factor Pathway InhibitorATIIIProtein C

Insulin

NitricOxide

ThrombinAmplificationFactor IX

Peripheral Nerves

ATP

Ca+

ThrombinAcceleration

Analgesia

Thrombin Activation

TISSUE FACTOR

PAI

TPA

Factor VII

THROMBIN

Factor VIIIC

VON WILLIBRAND FACTOR

PeripheralReceptors

TAFI

FIBRONIGEN

Factor X

Sensory Stressors

FibrinSplit Products

Insoluble Fibrin

SOLUBLEFIBRIN

Factor XIII

SPINAL PATHWAY

Fibronectin

Vitronectin

TISSUEREPAIR

COAGULATION

PlateletsInflammationChemotaxisMitosis

SYSTOLICTURBULENTRESISTANCE

PusScabsCastsExudates

Abscesses

CAPILLARYFLOW

CAPILLARYHEMOSTASIS

SYSTOLICLAMINARFLOW

TemperatureCatabolismFeverImmune CellsEndotheliumOsteoblastsMyoblastsFibroblastsCollagen

ImmuneProteins

MetabolismAngiogenesisChemokinesCytokinesProstaglandins

Malignancy

Apoptosis

HyperviscosityHypercoagulableFlow ResistanceIncreased SWR

Cardiac WorkHypertensionDecreased CO

Atherosclerosis

Optimal ViscosityNormocoagulableFlow FacilitationDecreased SVRCardiac RestHypertensionIncreased COHealth & Longevity

Tissue PerfusionHyperoxemiaOrgan ActivityDecreased SVROrgan PreservationHypotensionIncreased CODecreased HR

Tissue IschemiaHypoxemiaOrgan QuiescenceIncreased SWROrgan StressHypertensionDecreased COIncreased HR

BoneMuscle

PneumoniaInfluenzaAsthmaARDSMSOFEclampsiaARF

FibrosisScarAdhesion



Blood acceleration turbulence
Blood Acceleration & Turbulence

Systolic Acceleration

Diastolic Deceleration

Diastolic Turbulence


Pipe flow turbulence
Pipe Flow Turbulence

Lateral Forces

Fast

Faster

Fastest


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