A World Leader in Point-of-care and Critical Care Testing

1. A World Leader in Point-of-care and Critical Care Testing

2. The Only Glucose Meter FDA-Cleared for Use with Critically Ill Patients

3. The Only Glucose Meter FDA-Cleared for Use with Critically Ill Patients Surgery and Recovery Oncology and Dialysis Neonatal Intensive Care Intensive Care Inpatient Emergency and Trauma

4. Comprehensive Test Menu for Monitoring Chronic Illness Diabetes/GlycaemicControl HbA1c eAG* Glucose Kidney Disease Urine creatinine           Urine albumin Urine albumin/creatinine ratio* Blood creatinine eGFR* Cardiovascular Disease/Lipids Total cholesterol HDL cholesterol Cholesterol/HDL ratio* Non-HDL cholesterol* LDL cholesterol* Triglycerides Hemostasis PT/INR Allegrois the only analyser that can measure all tests, from a capillary blood sample (except for the two urine tests). *Calculated test

5. All Tests Measured with Disposable Cartridges or Test Strips • Diabetes/GlycaemicContol Cartridge • 1.5 µL capillary blood • HbA1c • eAG • Cardiovascular Disease/Lipids Panel • 5 µL capillary blood • Total Cholesterol • HDL Cholesterol • Triglycerides • LDL Cholesterol • Cholesterol/HDL ratio • Non-HDL Cholesterol • Kidney Function Cartridge • 25 µL urine • Urine Albumin • Urine Creatinine • Albumin/Creatinine ratio • Homostatis • PT (Prothrombin Time) PT/INR • 0.8 µL capillary blood • Diabetes and Kidney Function Test Strips • Blood GLucose • 1.2 µL capillary blood • Blood Creatinine with eGFR • 1.6 µL capillary blood

6. Test Menu Comparison

7. All Blood Tests Use Capillary Fingerstick Samples Eliminates the need for a trained phlebotomist, venipuncture, blood drawing tubes and needles. Allegro’s small blood drop makes capillary testing virtually painless for the patient.

8. Simple Test Procedure Perform fingerstick Touch sampler to blood Replace capillary sampler Insert cartridge and press “Analyse” Scan cartridge Remove capillary sampler

9. One System, Two Measuring Technologies, One Patient Report Biosensor and immunoassay technologies are combined to provide a complete test menu. Immunoassay technology Biosensor technology

10. Two Measurement Bays Provide Fast Testing Times 6 minutes 9.5 minutes Allegro’s rapid test times and ability to measure 2 cartridges simultaneously doubles throughput. 6.5 minutes 10-60 seconds

11. More Tests in Less Time *Single-test-bay instrument **Includes 2 minutes to perform second fingerstick and prepare lipids cartridge after completing HbA1c test

12. Allegro Delivers Accurate, Lab Quality Results HbA1c Method Comparison Analysis1 Nova Allegro v. Tosoh G8 (HPLC) Bias at HbA1c Medical Decision Levels1 Nova Allegro v. Tosoh G8 (HPLC) No HbA1c interferences from: Hb A2, Hb C, Hb D, Hb E, Hb F, Hb G, Hb S, Pre-glycated and acetylated hemoglobin 1. Data from U.S. FDA 510(k) submission

13. Only HbA1c Analyser with Blood Glucose Uses Nova’s StatStrip hospital glucose biosensor • No known interferences • Used by thousands of hospitals worldwide • Only glucose test accurate enough to be cleared by the    U.S. FDA for use with all patients including critically ill • 1.2 microliter capillary blood sample, Glucose results in 6 seconds Wirelessly transmits results to Allegro for a combined report with cartridge test results.

14. Immediate Printed Results and Patient Trend Reports “This would be a particular value for non-compliant patients, especially ones that often miss appointments. Having HbA1c and lipids in their presence is huge, especially showing them trends.”1 “Very important factor—immediate, tangible, objective information and feedback.”1 “Patients respond best with numbers in front of them.”1 “Patients respond best to immediate feedback. This also limits loss to follow-up.”1 1. Pri-Med primary care physician focus group survey. Oct 2015

15. Connects to Electronic Medical Records EMR HL7 or POCT1-A2 Electronic Interface Allegro stores a virtually unlimited number of patient results on board the analyser. These results can be recalled from the Allegro database for review, printing, or transmission to an EMR. Allegro instantly transmits test results to the EMR by industry standard HL7 or POCT1-A2 interface formats. 15

16. CompactTakes Little Space Analyser Allegro easily fits in clinician offices, clinics, and hospital outpatient locations. It can also be operated on an optional mobile cart. Physical Specifications Width 20.32 cm (8 in) Height 35.6 cm (14 in) Depth 38.1 cm (15 in) Weight 10.43 kg (23 lb) 35.6 cm (14 in) 38.1 cm (15 in) 20.32 cm (8 in) 16

17. Point-of-Care testing Reduces Patient Visits and Medical Issues In-office testing eliminates: • Patient referral to an outside lab • Venipuncture and sample send out • Follow-up to contact patient with test results • Scheduling and conducting another patient visit after blood test results are known • Follow-up with patients who do not get their blood tested • Medical issues with patients who do not get their blood tested

18. Provides Operational Cost Savings A study at a primary care clinic at Massachusetts General Hospital (Boston, MA) reported that point-of-care testing (POCT) for HbA1c, lipids, and urine albumin and creatinine achieved significant operational savings of $24.64 per patient visit, accomplished through workflow reduction. Specifically, POCT resulted in: • 89% reduction in follow-up calls • 85% reduction in follow-up letters and emails with test results • 62% reduction in follow-up visits for patients with an abnormal laboratory result1 1. Crocker J et al. Implementation of point-of-care testing in an ambulatory practice of an academic medical center. Am J ClinPathol2014;142:640-646 18

19. Improves Patient Care HbA1c POCT has been shown to impact HbA1c levels.1,2 HbA1c POCT has been shown to positively impact provider compliance with ADA recommendations for HbA1c testing frequency and therapy intensification.2,3 HbA1c POCT enhances interaction between the healthcare provider and the patient.4 Patients view POCT as strengthening their relationship with their provider and motivational in terms of better managing their condition.4,5 Patients report a high level of satisfaction with capillary sampling process and overall testing experience.4,6 1. Petersen JR et al. Effect of point-of-care on maintenance of glycemic control as measured by A1C. Diabetes Care 2007;30:713-715. 2. Egbunike V et al. The impact of point-of-care A1C testing on provider compliance and A1C levels in a primary setting. Diabetes Educ 2013;39:66-73. 3. Miller CD et al. Rapid A1c availability improves clinical decision-making in an urban primary care clinic. Diabetes Care 2003;26:1158-1163. 4. Laurence CO et al. Patient satisfaction with point-of-care testing in general practice. Br J Gen Pract2010;March:e98-e104. 5. Shephard MD. Cultural and clinical effectiveness of the ‘QAAMS’ point-of-care testing model for diabetes management in Australian Aboriginal Medical Services. ClinBiochem Rev 2006;27:161-170. 6. Crocker B et al. Patient satisfaction with point-of-care laboratory testing: Report of a quality improvement program in an ambulatory practice of an academic medical center. ClinChimActa 2013;424;8-11. 19

20. Fast, Simple, Capillary Blood Analyser 15-test menu for monitoring chronic illness Immediate results during the patient visit Simplifies workflow, reduces patient follow-up visits and costs Improves patient satisfaction and compliance 20